Results 41 to 50 of about 11,750 (172)

LC3/GABARAPs drive ubiquitin-independent recruitment of Optineurin and NDP52 to amplify mitophagy

Nature Communications, 2019
Selective autophagy receptors are thought to selectively recruit Atg8 positive membranes to cargo via their LIR motif. Here, the authors show the LIR motifs in OPTN and NDP52 are dispensable for selectivity, functioning instead to recruit additional ...
Benjamin Scott Padman, Thanh Ngoc Nguyen, Louise Uoselis, Marvin Skulsuppaisarn, Lan K. Nguyen, Michael Lazarou   +5 more
doaj   +1 more source

Atg8-Family Proteins—Structural Features and Molecular Interactions in Autophagy and Beyond

Cells, 2020
Autophagy is a common name for a number of catabolic processes, which keep the cellular homeostasis by removing damaged and dysfunctional intracellular components.
Nicole Wesch, Vladimir Kirkin, Vladimir V. Rogov   +2 more
doaj   +1 more source

The nonstructural protein 1 of respiratory syncytial virus hijacks host mitophagy as a novel mitophagy receptor to evade the type I IFN response in HEp-2 cells

mBio, 2023
Mitochondria are good targets for viruses to manipulate their hosts. However, it remains obscure whether respiratory syncytial virus (RSV) target mitochondria to suppress the type I interferon (IFN) responses.
Jing Cheng, Yutong Wang, Lizheng Yin, Wenzhang Liang, Jing Zhang, Cuiqing Ma, Yu Zhang, Bo Liu, Jiachao Wang, Weiting Zhao, Miao Li, Lin Wei   +11 more
doaj   +1 more source

Molecular determinants regulating selective binding of autophagy adapters and receptors to ATG8 proteins

Nature Communications, 2019
Autophagy adaptors and receptors contain LC3-interacting region (LIR) motifs that bind selectively to the LIR docking site of GABARAP and other members of the ATG8 family. Here the authors show that in addition to the LIR motif also the region C-terminal
Martina Wirth, Wenxin Zhang, Minoo Razi, Lynet Nyoni, Dhira Joshi, Nicola O’Reilly, Terje Johansen, Sharon A. Tooze, Stéphane Mouilleron   +8 more
doaj   +1 more source

Receptor proteins in selective autophagy [PDF]

, 2012
Autophagy has long been thought to be an essential but unselective bulk degradation pathway. However, increasing evidence suggests selective autophagosomal turnover of a broad range of substrates.
Behrends, Christian, Fulda, Simone
core   +1 more source

The interplay between pathogens and Atg8 family proteins: thousand‐faced interactions

FEBS Open Bio, 2021
Autophagy is an intracellular degradation and recycling process that can also remove pathogenic intracellular bacteria and viruses from within cells (referred to as xenophagy) and activate the adaptive immune responses.
Dávid Tóth, Gábor V. Horváth, Gábor Juhász   +2 more
doaj   +1 more source

Identification and Expression Analysis of the Solanum tuberosum StATG8 Family Associated with the WRKY Transcription Factor

Plants, 2022
Autophagy is an evolutionarily well-conserved cellular catabolic pathway in eukaryotic cells and plays an important role in cellular processes. Autophagy is regulated by autophagy-associated (ATG) proteins.
Injeong Song, Suji Hong, Sung Un Huh
doaj   +1 more source

AMBRA1 is able to induce mitophagy via LC3 binding, regardless of PARKIN and p62/SQSTM1 [PDF]

, 2014
Damaged mitochondria are eliminated by mitophagy, a selective form of autophagy whose dysfunction associates with neurodegenerative diseases. PINK1, PARKIN and p62/SQTMS1 have been shown to regulate mitophagy, leaving hitherto ill-defined the ...
A Follenzi, A Orvedahi, A Romagnoli, C Behrends, C Van Humbeeck, C Vives-Bauza, D Popovic, DP Narendra, EF Blommaart, F Cecconi, F Cecconi, F Nazio, F Nazio, F Strappazzon, F Strappazzon, G M Fimia, G Twig, GM Fimia, H Sandoval, J Jin, J Lippincott-Schwartz, JY Lee, K Okamoto, K Okatsu, M Campanella, M Campanella, M Corrado, M Cozzolino, M Kundu, M Piacentini, N Narendra, P Grumati, PA Andreux, PO Seglen, R Nardacci, RL Schweers, S Campello, S Geisler, S Hasson, S Pankiv, S Pistor, T Itoh, T Johansen, T Kanki, V Choubey, V Cianfanelli, Y Kabeya   +46 more
core   +4 more sources

The MAP4 Projection Domain Accelerates Hypoxia-Induced Mitophagy Disruption through LIR Motif in Cardiomyocytes

, 2021
Abstract Previously, we and other investigators have demonstrated that phosphorylated microtubule-associated protein 4 (p-MAP4) impacts myocardial hypertrophy and ischemic heart failure. However, the detailed mechanism behind this remains under elucidated.
Yuesheng Huang, Yanhai Feng, Qiong Zhang, Lingfei Li, Junhui Zhang, Yao Huang, Yanling Lv, Jiezhi Jia, Dongxia Zhang, Gaoxing Luo, Jiongyu Hu   +10 more
openaire   +1 more source

Development of GABARAP family protein-sensitive LIR-based probes for neuronal autophagy

Molecular Brain, 2019
Autophagy allows for lysosomal cellular degradation of cytosolic components. In particular, neuronal autophagy is essential for cellular homeostasis and neuronal survival and is tightly regulated by several autophagy-related (ATG) proteins in post ...
Pureum Jeon, Ju-Hui Park, Yong-Woo Jun, You-Kyung Lee, Deok-Jin Jang, Jin-A Lee   +5 more
doaj   +1 more source