Results 41 to 50 of about 3,587 (132)
Plants, 2022 Autophagy is an evolutionarily well-conserved cellular catabolic pathway in eukaryotic cells and plays an important role in cellular processes. Autophagy is regulated by autophagy-associated (ATG) proteins.
Injeong Song, Suji Hong, Sung Un Huh
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Autophagy Reports, 2023 MTFP1 (mitochondrial fission process 1), an inner mitochondrial membrane protein, plays a crucial role in mitochondrial fission to maintain mitochondrial morphology.
Debasna P Panigrahi, Sujit K Bhutia
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Acta Pharmaceutica Sinica B, 2022 Chemoresistance remains a major obstacle to successful treatment of triple negative breast cancer (TNBC). Identification of druggable vulnerabilities is an important aim for TNBC therapy.
Minmin Fan +10 more
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Mechanisms of selective autophagy and mitophagy: Implications for neurodegenerative diseases
Neurobiology of Disease, 2019 Over the past 20 years, the concept of mammalian autophagy as a nonselective degradation system has been repudiated, due in part to important discoveries in neurodegenerative diseases, which opened the field of selective autophagy. Protein aggregates and
Charleen T. Chu
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Cell Reports, 2020 Summary: Autophagy is the degradation of cytoplasmic material through the lysosomal pathway. One of the most studied autophagy-related proteins is LC3.
Anne-Claire Jacomin +13 more
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, 2021 Abstract Previously, we and other investigators have demonstrated that phosphorylated microtubule-associated protein 4 (p-MAP4) impacts myocardial hypertrophy and ischemic heart failure. However, the detailed mechanism behind this remains under elucidated.
Yuesheng Huang +10 more
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Analysis of the native conformation of the LIR/AIM motif in the Atg8/LC3/GABARAP-binding proteins
, 2016 The Atg8/LC3/GABARAP family of proteins, a group that has structural homology with ubiquitin, connects with a large set of binding partners to function in macroautophagy (hereafter autophagy).
Daniel J Klionsky (754614) +1 more
core +1 more source
GMAP is an Atg8a-interacting protein that regulates Golgi turnover in Drosophila [PDF]
, 2022 Selective autophagy receptors and adapters contain short linear motifs called LIR motifs (LC3-interacting re- gion), which are required for the interaction with the Atg8-family proteins.
Csordás, Gábor +5 more
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Structure and Dynamics in the ATG8 Family From Experimental to Computational Techniques
Frontiers in Cell and Developmental Biology, 2020 Autophagy is a conserved and essential intracellular mechanism for the removal of damaged components. Since autophagy deregulation is linked to different kinds of pathologies, it is fundamental to gain knowledge on the fine molecular and structural ...
Valentina Sora +6 more
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AlphaFold2 SLiM screen for LC3-LIR interactions in autophagy. [PDF]
AutophagyIn selective macroautophagy/autophagy, cargo recruitment is mediated by MAP1LC3/LC3-interacting regions (LIRs)/Atg8-family interacting motifs (AIMs) in the cargo or cargo receptor proteins.
Stuke JFM, Hummer G.
europepmc +2 more sources