Results 51 to 60 of about 11,750 (172)
Autophagy Reports, 2023 MTFP1 (mitochondrial fission process 1), an inner mitochondrial membrane protein, plays a crucial role in mitochondrial fission to maintain mitochondrial morphology.
Debasna P Panigrahi, Sujit K Bhutia
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Acta Pharmaceutica Sinica B, 2022 Chemoresistance remains a major obstacle to successful treatment of triple negative breast cancer (TNBC). Identification of druggable vulnerabilities is an important aim for TNBC therapy.
Minmin Fan +10 more
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Autophagy in Microglia and Alzheimer's disease [PDF]
, 2019 Alzheimer’s disease (AD) is the most common neurodegenerative disease, characterized by amyloid-beta plaques, neurofibrillary tangles and neuroinflammation. Autophagy has been associated with several neurodegenerative diseases.
Houtman, Judith
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Mechanisms of selective autophagy and mitophagy: Implications for neurodegenerative diseases
Neurobiology of Disease, 2019 Over the past 20 years, the concept of mammalian autophagy as a nonselective degradation system has been repudiated, due in part to important discoveries in neurodegenerative diseases, which opened the field of selective autophagy. Protein aggregates and
Charleen T. Chu
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Cell Reports, 2020 Summary: Autophagy is the degradation of cytoplasmic material through the lysosomal pathway. One of the most studied autophagy-related proteins is LC3.
Anne-Claire Jacomin +13 more
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Optineurin functions for optimal immunity [PDF]
, 2018 Optineurin (OPTN) was identified 20 years ago in a yeast-two-hybrid screen with a viral protein known to inhibit the cytolytic effects of tumor necrosis factor.
Slowicka, Karolina, van Loo, Geert
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State College Times, November 2, 1932 [PDF]
, 1932 Volume 21, Issue 24https://scholarworks.sjsu.edu/spartan_daily_1932/1088/thumbnail ...
San Jose State University, School of Journalism and Mass Communications
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Host-pathogen interactions and subversion of autophagy [PDF]
, 2017 Macroautophagy (“autophagy”), is the process by which cells can form a double membraned vesicle that encapsulates material to be degraded by the lysosome.
Alemu +104 more
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LIR motifs and the membrane-targeting domain are complementary in the function of RavZ
BMB Reports, 2019 The bacterial effector protein RavZ is secreted by the intracellular pathogen Legionella pneumophila and inhibits host autophagy through an irreversible deconjugation of mammalian ATG8 (mATG8) proteins from autophagosome membranes. However, the roles of the LC3 interacting region (LIR) motifs in RavZ function remain unclear. In this study, we show that
Park, Sang-Won +7 more
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Structure and Dynamics in the ATG8 Family From Experimental to Computational Techniques
Frontiers in Cell and Developmental Biology, 2020 Autophagy is a conserved and essential intracellular mechanism for the removal of damaged components. Since autophagy deregulation is linked to different kinds of pathologies, it is fundamental to gain knowledge on the fine molecular and structural ...
Valentina Sora +6 more
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