Results 51 to 60 of about 3,587 (132)

PACSIN2 as a modulator of autophagy and mercaptopurine cytotoxicity: mechanisms in lymphoid and intestinal cells

Life Science Alliance, 2023
This study evaluates the role of PACSIN2 in autophagy modulation and its impact on mercaptopurine cytotoxicity in lymphoid and intestinal models.
Giulia Zudeh, Raffaella Franca, Marianna Lucafò, Erik J Bonten, Matteo Bramuzzo, Riccardo Sgarra, Cristina Lagatolla, Martina Franzin, William E Evans, Giuliana Decorti, Gabriele Stocco   +10 more
doaj   +1 more source

Molecular mechanism to target the endosomal Mon1-Ccz1 GEF complex to the pre-autophagosomal structure

eLife, 2018
During autophagy, a newly formed double membrane surrounds its cargo to generate the so-called autophagosome, which then fuses with a lysosome after closure.
Jieqiong Gao, Lars Langemeyer, Daniel Kümmel, Fulvio Reggiori, Christian Ungermann   +4 more
doaj   +1 more source

Positional specialization of LIR motifs in RavZ and the autophagy-related protein ATG4B

Autophagy Reports
LC3-interacting region (LIR) motifs are essential for recruiting proteins onto autophagosomes, the hallmark of autophagy. We recently explored the relevance of the specific position of the LIRs in RavZ and ATG4B (autophagy-related 4B). RavZ's N-terminal LIRs drive substrate recognition and enzymatic activity, while its C-terminal LIR aids membrane ...
Sang-Won Park, Jin-A Lee, Deok-Jin Jang
openaire   +3 more sources

The inflammation repressor TNIP1/ABIN-1 is degraded by autophagy following TBK1 phosphorylation of its LIR [PDF]

, 2023
The inflammatory repressor TNIP1/ABIN-1 is important for keeping in check inflammatory and cell-death pathways to avoid potentially dangerous sustained activation of these pathways.
Olsvik, Hallvard Lauritz, Trond Lamark, Jianwen Zhou, Nikoline L. Rasmussen, Terje Johansen, Rasmussen, Nikoline Lander, Stéphanie Kaeser-Pebernard, Hallvard Olsvik, Zhou, Jianwen, Joern Dengjel, Lamark, Trond, Kaeser-Pebernard, Stéphanie, Johansen, Terje, Dengjel, Joern   +13 more
core   +1 more source

Semisynthetic LC3 Probes for Autophagy Pathways Reveal a Noncanonical LC3 Interacting Region Motif Crucial for the Enzymatic Activity of Human ATG3

, 2023
Macroautophagy is one of two major degradation systems in eukaryotic cells. Regulation and control of autophagy are often achieved through the presence of short peptide sequences called LC3 interacting regions (LIR) in autophagy-involved proteins.
Roger M. Benoit (2610313), Jacob E. Corn (9636831), Jeffrey W. Bode (1331538), Matthias Muhar (428641), Kateryna A. Tolmachova (15367533), Jakob Farnung (12558000), Jin Rui Liang (12558003)   +6 more
core   +2 more sources

ULK1 promotes mitophagy via phosphorylation and stabilization of BNIP3

Scientific Reports, 2021
UNC51-like kinase-1 (ULK1) is the catalytic component of the autophagy pre-initiation complex that stimulates autophagy via phosphorylation of ATG14, BECLN1 and other autophagy proteins.
Logan P. Poole, Althea Bock-Hughes, Damian E. Berardi, Kay F. Macleod   +3 more
doaj   +1 more source

Caspase cleavage of influenza A virus M2 disrupts M2-LC3 interaction and regulates virion production

EMBO Reports
Influenza A virus (IAV) Matrix 2 protein (M2) is an ion channel, required for efficient viral entry and egress. M2 interacts with the small ubiquitin-like LC3 protein through a cytoplasmic C-terminal LC3-interacting region (LIR).
Carmen Figueras-Novoa, Masato Akutsu, Daichi Murata, Anne Weston, Ming Jiang, Beatriz Montaner, Christelle Dubois, Avinash Shenoy, Rupert Beale   +8 more
doaj   +1 more source

Transcription Factor Deformed Wings Is an Atg8a-Interacting Protein That Regulates Autophagy

Cells
LC3 (microtubule-associated protein 1 light chain 3, called Atg8 in yeast and Drosophila) is one of the most well-studied autophagy-related proteins. LC3 controls the selectivity of autophagic degradation by interacting with LIR (LC3-interacting region ...
Marta Kołodziej, Panagiotis Tsapras, Alexander D. Cameron, Ioannis P. Nezis   +3 more
doaj   +1 more source

Herpesvirus lytic infection-induced mitophagy via viral interferon regulatory factor 1

Autophagy Reports, 2023
Viral control of mitochondria via mitophagy has a dampening effect on mitochondrion-mediated innate immune responses. We previously found that human herpesvirus 8 (HHV-8) could activate mitophagy via its lytic gene product vIRF-1 (viral interferon ...
Mai Tram Vo, Young Bong Choi
doaj   +1 more source

Selective autophagy and Golgi quality control in Drosophila [PDF]

, 2022
The LIR motif-docking site (LDS) of Atg8/LC3 proteins is essential for the binding of LC3-interacting region (LIR)-containing proteins and their subsequent degradation by macroautophagy/autophagy.
Csordás, Gábor, Rahman, Ashrafur, Nagy, Anikó, Nezis, Ioannis P., Lőrincz, Peter, Gohel, Raksha, Zhang, Yan, Juhász, Gábor   +7 more
core   +1 more source