Results 31 to 40 of about 240,005 (160)

LIR motifs and the membrane-targeting domain are complementary in the function of RavZ

BMB Reports, 2019
The bacterial effector protein RavZ is secreted by the intracellular pathogen Legionella pneumophila and inhibits host autophagy through an irreversible deconjugation of mammalian ATG8 (mATG8) proteins from autophagosome membranes. However, the roles of the LC3 interacting region (LIR) motifs in RavZ function remain unclear. In this study, we show that
Park, Sang-Won, Jun, Yong-Woo, Jeon, Pureum, Lee, You-Kyung, Park, Ju-Hui, Lee, Seung-Hwan, Lee, Jin-A, Jang, Deok-Jin   +7 more
openaire   +3 more sources

ATG8-Interacting Motif: Evolution and Function in Selective Autophagy of Targeting Biological Processes

Frontiers in Plant Science, 2021
Autophagy is an evolutionarily conserved vacuolar process functioning in the degradation of cellular components for reuse. In plants, autophagy is generally activated upon stress and its regulation is executed by numbers of AuTophaGy-related genes (ATGs),
Wanqing Liu, Wanqing Liu, Zinan Liu, Zulong Mo, Shaoying Guo, Yunfeng Liu, Qingjun Xie   +6 more
doaj   +1 more source

LC3/GABARAPs drive ubiquitin-independent recruitment of Optineurin and NDP52 to amplify mitophagy

Nature Communications, 2019
Selective autophagy receptors are thought to selectively recruit Atg8 positive membranes to cargo via their LIR motif. Here, the authors show the LIR motifs in OPTN and NDP52 are dispensable for selectivity, functioning instead to recruit additional ...
Benjamin Scott Padman, Thanh Ngoc Nguyen, Louise Uoselis, Marvin Skulsuppaisarn, Lan K. Nguyen, Michael Lazarou   +5 more
doaj   +1 more source

Molecular determinants regulating selective binding of autophagy adapters and receptors to ATG8 proteins

Nature Communications, 2019
Autophagy adaptors and receptors contain LC3-interacting region (LIR) motifs that bind selectively to the LIR docking site of GABARAP and other members of the ATG8 family. Here the authors show that in addition to the LIR motif also the region C-terminal
Martina Wirth, Wenxin Zhang, Minoo Razi, Lynet Nyoni, Dhira Joshi, Nicola O’Reilly, Terje Johansen, Sharon A. Tooze, Stéphane Mouilleron   +8 more
doaj   +1 more source

Atg8-Family Proteins—Structural Features and Molecular Interactions in Autophagy and Beyond

Cells, 2020
Autophagy is a common name for a number of catabolic processes, which keep the cellular homeostasis by removing damaged and dysfunctional intracellular components.
Nicole Wesch, Vladimir Kirkin, Vladimir V. Rogov   +2 more
doaj   +1 more source

The nonstructural protein 1 of respiratory syncytial virus hijacks host mitophagy as a novel mitophagy receptor to evade the type I IFN response in HEp-2 cells

mBio, 2023
Mitochondria are good targets for viruses to manipulate their hosts. However, it remains obscure whether respiratory syncytial virus (RSV) target mitochondria to suppress the type I interferon (IFN) responses.
Jing Cheng, Yutong Wang, Lizheng Yin, Wenzhang Liang, Jing Zhang, Cuiqing Ma, Yu Zhang, Bo Liu, Jiachao Wang, Weiting Zhao, Miao Li, Lin Wei   +11 more
doaj   +1 more source

The interplay between pathogens and Atg8 family proteins: thousand‐faced interactions

FEBS Open Bio, 2021
Autophagy is an intracellular degradation and recycling process that can also remove pathogenic intracellular bacteria and viruses from within cells (referred to as xenophagy) and activate the adaptive immune responses.
Dávid Tóth, Gábor V. Horváth, Gábor Juhász   +2 more
doaj   +1 more source

Identification and Expression Analysis of the Solanum tuberosum StATG8 Family Associated with the WRKY Transcription Factor

Plants, 2022
Autophagy is an evolutionarily well-conserved cellular catabolic pathway in eukaryotic cells and plays an important role in cellular processes. Autophagy is regulated by autophagy-associated (ATG) proteins.
Injeong Song, Suji Hong, Sung Un Huh
doaj   +1 more source

Correlating motif analysis and morphological filters for surface texture analysis [PDF]

, 2013
In contrast to the mean-line based evaluation system, motif analysis and morphological filters are two techniques oriented to the characterization of functional properties of surfaces.
Lou, Shan, Jiang, Xiangqian, Scott, Paul J.   +2 more
core   +1 more source

Development of GABARAP family protein-sensitive LIR-based probes for neuronal autophagy

Molecular Brain, 2019
Autophagy allows for lysosomal cellular degradation of cytosolic components. In particular, neuronal autophagy is essential for cellular homeostasis and neuronal survival and is tightly regulated by several autophagy-related (ATG) proteins in post ...
Pureum Jeon, Ju-Hui Park, Yong-Woo Jun, You-Kyung Lee, Deok-Jin Jang, Jin-A Lee   +5 more
doaj   +1 more source