Results 31 to 40 of about 3,587 (132)

Label-free quantitative proteomic analysis of adult Drosophila heads

STAR Protocols, 2022
Summary: LIR motif-containing proteins (LIRCPs) bind to LDS (LIR motif docking site) of Atg8-family proteins. In this protocol, we describe steps to identify Drosophila LIRCPs, in Atg8a LDS mutants we have created, via label-free quantitative proteomic ...
Yan Zhang, Ioannis P. Nezis
doaj   +1 more source

The crystal structure of the FAM134B–GABARAP complex provides mechanistic insights into the selective binding of FAM134 to the GABARAP subfamily

FEBS Open Bio, 2022
The mammalian Atg8 family (Atg8s proteins) consists of two subfamilies: GABARAP and LC3. All members can bind to the LC3‐interacting region (LIR) or Atg8‐interacting motif and participate in multiple steps of autophagy.
Junfeng Zhao, Zhiwei Li, Jianchao Li
doaj   +1 more source

Biological properties of the BCL-2 family protein BCL-RAMBO, which regulates apoptosis, mitochondrial fragmentation, and mitophagy

Frontiers in Cell and Developmental Biology, 2022
Mitochondria play an essential role in the regulation of cellular stress responses, including cell death. Damaged mitochondria are removed by fission and fusion cycles and mitophagy, which counteract cell death.
Takao Kataoka, Takao Kataoka
doaj   +1 more source

Use of Peptide Arrays for Identification and Characterization of LIR Motifs [PDF]

, 2019
The mammalian ATG8 proteins (LC3A-C/GABARAP, GABARAPL1, and GABARAPL2) are small ubiquitin-like proteins critically involved in macroautophagy. Their processed C-termini are posttranslationally conjugated to a phosphatidylethanolamine moiety, enabling their insertion into the lipid bilayers of both the inner and outer membranes of the forming ...
Rasmussen, Mads Skytte, Birgisdottir, Åsa birna, Johansen, Terje   +2 more
openaire   +3 more sources

iLIR : a web resource for prediction of Atg8-family interacting proteins [PDF]

, 2014
Macroautophagy was initially considered to be a nonselective process for bulk breakdown of cytosolic material. However, recent evidence points toward a selective mode of autophagy mediated by the so-called selective autophagy receptors (SARs).
Nezis, I. P., Osgood, Richard, Mulakkal, Nitha Charles, Promponas, Vasilis J., Kalvari, Ioanna, Johansen, Terje, Tsompanis, Stelios   +6 more
core   +1 more source

ATG8-Interacting Motif: Evolution and Function in Selective Autophagy of Targeting Biological Processes

Frontiers in Plant Science, 2021
Autophagy is an evolutionarily conserved vacuolar process functioning in the degradation of cellular components for reuse. In plants, autophagy is generally activated upon stress and its regulation is executed by numbers of AuTophaGy-related genes (ATGs),
Wanqing Liu, Wanqing Liu, Zinan Liu, Zulong Mo, Shaoying Guo, Yunfeng Liu, Qingjun Xie   +6 more
doaj   +1 more source

LIR motifs and the membrane-targeting domain are complementary in the function of RavZ

BMB Reports, 2019
The bacterial effector protein RavZ is secreted by the intracellular pathogen Legionella pneumophila and inhibits host autophagy through an irreversible deconjugation of mammalian ATG8 (mATG8) proteins from autophagosome membranes. However, the roles of the LC3 interacting region (LIR) motifs in RavZ function remain unclear. In this study, we show that
Park, Sang-Won, Jun, Yong-Woo, Jeon, Pureum, Lee, You-Kyung, Park, Ju-Hui, Lee, Seung-Hwan, Lee, Jin-A, Jang, Deok-Jin   +7 more
openaire   +3 more sources

Atg8-Family Proteins—Structural Features and Molecular Interactions in Autophagy and Beyond

Cells, 2020
Autophagy is a common name for a number of catabolic processes, which keep the cellular homeostasis by removing damaged and dysfunctional intracellular components.
Nicole Wesch, Vladimir Kirkin, Vladimir V. Rogov   +2 more
doaj   +1 more source

The nonstructural protein 1 of respiratory syncytial virus hijacks host mitophagy as a novel mitophagy receptor to evade the type I IFN response in HEp-2 cells

mBio, 2023
Mitochondria are good targets for viruses to manipulate their hosts. However, it remains obscure whether respiratory syncytial virus (RSV) target mitochondria to suppress the type I interferon (IFN) responses.
Jing Cheng, Yutong Wang, Lizheng Yin, Wenzhang Liang, Jing Zhang, Cuiqing Ma, Yu Zhang, Bo Liu, Jiachao Wang, Weiting Zhao, Miao Li, Lin Wei   +11 more
doaj   +1 more source

The interplay between pathogens and Atg8 family proteins: thousand‐faced interactions

FEBS Open Bio, 2021
Autophagy is an intracellular degradation and recycling process that can also remove pathogenic intracellular bacteria and viruses from within cells (referred to as xenophagy) and activate the adaptive immune responses.
Dávid Tóth, Gábor V. Horváth, Gábor Juhász   +2 more
doaj   +1 more source