A GABARAP−PtdIns3K-C1 positive feedback loop at the heart of the phagophore nucleation [PDF]
Nature CommunicationsIn mammalian cells, autophagosomes can reach diameters of over 1000 nm within 30 min after triggering starvation, but how such substantial amounts of membranes can be synthesized remains elusive.
Antoine N. Dessus +7 more
doaj +3 more sources
ANGPT1–GABARAP axis modulates NLRP3 inflammasome–mediated pyroptosis in Crohn’s disease [PDF]
Frontiers in ImmunologyBackgroundCrohn’s disease (CD) is characterized by persistent intestinal inflammation, immune dysregulation, and intestinal barrier dysfunction. Inflammasome-mediated pyroptosis is an innate immune mechanism increasingly implicated in inflammatory bowel ...
Yanchen Li +7 more
doaj +2 more sources
Banxia Shumi Decoction Alleviates PCPA-Induced Insomnia and Regulates ADAM10 Expression via Melatonin Signaling in Rats. [PDF]
CNS Neurosci TherThis study explored BXSMD's effect and mechanism on rat insomnia. Pentobarbital‐induced sleep tests showed that BXSMD shortened sleep latency and prolonged sleep duration compared with the model group. The mechanism relies on MT1/MT2 as core targets, which mediate the regulation of sleep‐related molecules (CLOCK, PER1, CaMKⅡ, p‐CREB/CREB, GABARAP, and ...
Guo B, Tang Y, Zhang Y, Wu Y, Gao R.
europepmc +2 more sources
The GABARAP Co-Secretome Identified by APEX2-GABARAP Proximity Labelling of Extracellular Vesicles
Cells, 2020 The autophagy-related ATG8 protein GABARAP has not only been shown to be involved in the cellular self-degradation process called autophagy but also fulfils functions in intracellular trafficking processes such as receptor transport to the plasma ...
Julia L Sanwald +2 more
exaly +3 more sources
A non-canonical ARMS-GABARAP interaction modulates dendritic spine formation and synaptic development [PDF]
The EMBO JournalARMS (ankyrin repeat-rich membrane spanning) is a scaffold protein essential for neurotrophic signaling, synaptic development, and cytoskeletal remodeling.
Wenli Jiang +9 more
doaj +2 more sources
FEBS Open Bio, 2022 The mammalian Atg8 family (Atg8s proteins) consists of two subfamilies: GABARAP and LC3. All members can bind to the LC3‐interacting region (LIR) or Atg8‐interacting motif and participate in multiple steps of autophagy.
Zhiwei Li, Jianchao Li
exaly +2 more sources
Targeting the microglial phosphatidylethanolamine synthesis pathway promotes GABARAP-associated phagocytosis and Aβ clearance in Alzheimer’s disease [PDF]
Signal Transduction and Targeted TherapyAlzheimer’s disease (AD) is a major cause of dementia and a prevalent age-related neurodegenerative disorder characterized by progressive cognitive impairment and memory loss.
Seung Jae Hyeon +20 more
doaj +2 more sources
Deficiency of GABARAP but Not Its Paralogs Causes Enhanced EGF-Induced EGFR Degradation
Cells, 2020 The γ-aminobutyric acid type A receptor-associated protein (GABARAP) and its close paralogs GABARAPL1 and GABARAPL2 constitute a subfamily of the autophagy-related 8 (Atg8) protein family.
Melanie Schwarten +2 more
exaly +3 more sources
Programmable Nanobody-Targeting Chimeras Enable Intracellular Viral Protein Degradation. [PDF]
Adv Sci (Weinh)Nab‐TAC enables targeted degradation of HBV surface antigen (HBsAg) in vivo. By fusing nanobody‐based recognition domains with programmable proteasome‐recruiting degradation signals, Nab‐TAC reduces HBsAg levels in a hydrodynamic HBV mouse model. ABSTRACT Chronic hepatitis B virus (HBV) infection remains a major global health challenge, largely because
Pan MY +11 more
europepmc +2 more sources
GABARAP proteins regulate the packaging of HIV-1 genomic RNA into virions [PDF]
EMBO ReportsIn addition to their role in canonical autophagy, autophagy proteins (ATG) contribute to various cellular processes, including phagocytosis, membrane remodeling, and vesicle secretion.
Marjory Palaric +9 more
doaj +2 more sources