Results 1 to 10 of about 10,278 (171)

A non-canonical ARMS-GABARAP interaction modulates dendritic spine formation and synaptic development [PDF]

The EMBO Journal
ARMS (ankyrin repeat-rich membrane spanning) is a scaffold protein essential for neurotrophic signaling, synaptic development, and cytoskeletal remodeling.
Wenli Jiang, Jin Ye, Jiasheng Chen, Xinyu Wang, Yahong Li, Jianchao Li, Yide Mei, Yanlu Lyu, Wei Hu, Chao Wang   +9 more
doaj   +2 more sources

GABARAP proteins regulate the packaging of HIV-1 genomic RNA into virions [PDF]

EMBO Reports
In addition to their role in canonical autophagy, autophagy proteins (ATG) contribute to various cellular processes, including phagocytosis, membrane remodeling, and vesicle secretion.
Marjory Palaric, Margaux Versapuech, Delphine Judith, Corentin Aubé, Marjorie Leduc, Jacques Dutrieux, Emilie-Fleur Gautier, Jean-Christophe Paillart, Sarah Gallois-Montbrun, Clarisse Berlioz-Torrent   +9 more
doaj   +2 more sources

The sigma-1 receptor as a neurohomeostatic decision hub for GABARAP-mediated receptor trafficking and macroautophagy [PDF]

Frontiers in Molecular Biosciences
Gamma-aminobutyric acid receptor-associated protein (GABARAP) is a multifunctional member of the autophagy-related (ATG8) protein family, playing key roles in two distinct cellular pathways: macroautophagy and plasma membrane protein trafficking.
Marius Wilhelm Baeken, Fazilet Bekbulat, Hagen Körschgen, Albrecht Martin Clement, Christian Behl   +4 more
doaj   +2 more sources

MAPK15/ERK8 stimulates autophagy by interacting with LC3 and GABARAP proteins [PDF]

Autophagy, 2012
Macroautophagy (hereafter referred to as autophagy) is an evolutionarily conserved catabolic process necessary for normal recycling of cellular constituents and for appropriate response to cellular stress.
David Colecchia, Federica Piccioni, Mario Chiariello   +2 more
exaly   +3 more sources

Conserved LIR-specific interaction of Sigma-1 receptor and GABARAP [PDF]

iScience
Summary: Among its various functions, the sigma-1 receptor (σ1R) has been reported to modulate macroautophagy. It is currently unknown how this activity is mediated. We phylogenetically, structurally, and biochemically analyzed σ1R regarding its function
Marius Wilhelm Baeken, Maximilian Christ, Daniel Schmitt, Wencke Trein, Heike Nagel, Albrecht Martin Clement, Hagen Körschgen, Christian Behl   +7 more
doaj   +2 more sources

Decoding the brain’s ATG8 paralog code: LC3–GABARAP specialization at synapses and the astrocyte–neuron interface [PDF]

Frontiers in Cell and Developmental Biology
Macroautophagy is essential for the long-term health of neurons and astrocytes in the central nervous system (CNS). The six mammalian ATG8 paralogs (LC3A/B/C and GABARAP/GABARAPL1/L2) exhibit an emerging “ATG8 code”—a division of labor among these ...
Haneul Choi, Seung-Min Lee, Jin-A. Lee
doaj   +2 more sources

Integrated multi-omics reveals GABARAP-mediated mitophagy and pyruvate metabolism as key drivers of osteosarcoma progression [PDF]

Frontiers in Immunology
BackgroundOsteosarcoma is a highly aggressive bone malignancy characterized by frequent metastasis and therapy resistance. Although mitophagy and pyruvate metabolism are increasingly recognized as critical metabolic regulators, their interaction in ...
Xiuxin Han, Xiuxin Han, Xiuxin Han, Yiqin Li, Yiqin Li, Yiqin Li, Yongheng Liu, Yongheng Liu, Yongheng Liu, Feng Wang, Tingfang Li, Qingchen Zhang, Qingchen Zhang, Guowen Wang, Guowen Wang, Guowen Wang, Jinyan Feng, Jinyan Feng, Jinyan Feng   +18 more
doaj   +2 more sources

Spatially Resolved Multiomics Reveals Metabolic Remodeling and Autophagy Activation in Adamantinomatous Craniopharyngiomas [PDF]

Advanced Science, Volume 13, Issue 17, 23 March 2026.
Multiomics integration analysis reveals the “cystic fluid–tumor cell” metabolic coupling that mediates active choline/ethanolamine uptake of tumor cells from cystic fluid and PC/PE synthesis pathways reprogramming that mediating autophagy pathway activation within ACP. ABSTRACT Adamantinomatous craniopharyngioma (ACP), a benign yet highly recurrent and
Dongting Chen, Yahui Gao, Yulin Wang, Ting Lei, Zheng Qu, Yuhan An, Jiaxu Fu, Xin Li, Fangjun Liu, Yan Li   +9 more
wiley   +2 more sources

Integrating bioinformatics analysis, machine learning, and experimental validation to identify pyroptosis-related genes in the diagnosis of sepsis combined with acute liver failure [PDF]

Hereditas
Background Sepsis is frequently combined with acute liver failure (ALF), a critical determinant in the mortality of septic patients. Pyroptosis is a significant form of programmed cell death that plays an important role in the inflammatory response ...
Jing Yan, Yifeng Pan, Chaoqi Chen, Lijian Liu, Jinjing Tan, Juan Li, Liqun Li, Sheng Xie   +7 more
doaj   +2 more sources

The double role of GABAergic system in systemic tumors: an updated review [PDF]

Frontiers in Oncology
The GABAergic system is the main inhibitory nervous system. In addition, GABA has been reported to affect tumor growth and its expression differs between tumor tissue and normal tissue.
Xueyang Yang, Qianhe Zu, Luxuan Wang, Chunhui Li, Lijian Zhang, Lijian Zhang   +5 more
doaj   +2 more sources