Results 41 to 50 of about 10,328 (211)
Prediction of GABARAP interaction with the GABA type A receptor [PDF]
Proteins: Structure, Function, and Bioinformatics, 2018 AbstractWe have performed docking simulations on GABARAP interacting with the GABA type A receptor using SwarmDock. We have also used a novel method to study hydration sites on the surface of these two proteins; this method identifies regions around proteins where desolvation is relatively easy, and these are possible locations where proteins can bind ...
Irwin, BWJ +4 more
openaire +3 more sources
A STING-CASM-GABARAP pathway activates LRRK2 at lysosomes. [PDF]
J Cell Biol, 2023 AbstractMutations that increase LRRK2 kinase activity have been linked to Parkinson’s disease and Crohn’s disease. LRRK2 is also activated by lysosome damage. However, the endogenous cellular mechanisms that control LRRK2 kinase activity are not well understood.
Bentley-DeSousa A +2 more
europepmc +3 more sources
Autophagy is essential for mouse sense of balance [PDF]
, 2010 . This work was supported by grants from Ministerio de Ciencia e Innovación-Spain, Fundación “M. Botín,” the European Union (FP7 MicroEnviMet) and the NIH (grant DC008603 to Y.W. Lundberg).
Cabanillas Farpón, Rubén +11 more
core +2 more sources
Autophagy gene haploinsufficiency drives chromosome instability, increases migration, and promotes early ovarian tumors. [PDF]
, 2020 Autophagy, particularly with BECN1, has paradoxically been highlighted as tumor promoting in Ras-driven cancers, but potentially tumor suppressing in breast and ovarian cancers.
Axelrod, Joshua +14 more
core +1 more source
Centrosome to autophagosome signaling: Specific GABARAP regulation by centriolar satellites [PDF]
Autophagy, 2017 Yeast have one Atg8 protein; however, multiple Atg8 orthologs (LC3s and GABARAPs) are found in humans. We discovered that a population of the Atg8 ortholog GABARAP resides on the centrosome and the peri-centrosomal region. This centrosomal pool of GABARAP translocates to forming autophagosomes upon starvation to activate autophagosome formation in a ...
Justin Joachim, Sharon A. Tooze
openaire +2 more sources
Biology Open, 2014 We previously reported that phospholipase C-related catalytically inactive protein (PRIP)-knockout mice exhibited hyperinsulinemia. Here, we investigated the role of PRIP in insulin granule exocytosis using Prip-knockdown mouse insulinoma (MIN6) cells ...
Satoshi Asano +8 more
doaj +1 more source
Human ATG3 binding to lipid bilayers: role of lipid geometry, and electric charge [PDF]
, 2017 Specific protein-lipid interactions lead to a gradual recruitment of AuTophaGy-related (ATG) proteins to the nascent membrane during autophagosome (AP) formation.
Alonso Izquierdo, Alicia +5 more
core +3 more sources
A functional analysis of GABARAP on 17p13.1 by knockdown zebrafish [PDF]
Journal of Human Genetics, 2010 Array-based comparative genomic hybridization identified a 2.3-Mb microdeletion of 17p13.2p13.1 in a boy presenting with moderate mental retardation, intractable epilepsy and dysmorphic features. This deletion region was overlapped with the previously proposed shortest region overlapped for microdeletion of 17p13.1 in patients with mental retardation ...
Yuta, Komoike +8 more
openaire +2 more sources
Frontiers in Veterinary Science, 2022 Brown adipose tissue (BAT) is mainly present in young mammals and is important for maintaining body temperature in neonatal mammals because of its ability to produce non-shivering thermogenesis.
Le Zhao +5 more
doaj +1 more source
In silico inhibition of GABARAP activity using antiepileptic medicinal derived compounds [PDF]
Bioinformation, 2015 Epilepsy is a neurological disorder affecting more than 50 million people worldwide. It can be controlled by antiepileptic drugs (AEDs) but more than 30% patients are still resistant to AEDs. To overcome this problem, researchers are trying to develop novel approaches to treat epilepsy including the use of herbal medicines.
Mathew, Shilu +4 more
openaire +2 more sources