Results 41 to 50 of about 7,891 (186)
Frontiers in Immunology, 2020 Sepsis is a life-threating multi-organ disease induced by host innate immunity to pathogen-derived endotoxins including lipopolysaccharide (LPS). Direct sensing of LPS by caspase-11 activates inflammasomes and causes lethal sepsis in mice.
Naoya Sakaguchi +12 more
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Autophagosome formation and cargo sequestration in the absence of LC3/GABARAPs [PDF]
Autophagy, 2017 It has been widely assumed that Atg8 family LC3/GABARAP proteins are essential for the formation of autophagosomes during macroautophagy/autophagy, and the sequestration of cargo during selective autophagy. However, there is little direct evidence on the functional contribution of these proteins to autophagosome biogenesis in mammalian cells.
Benjamin Scott, Padman +2 more
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GABARAP proteins as scaffolds in localized TIAM1-RAC1 signaling [PDF]
Molecular & Cellular Oncology, 2015 Spatially restricted signaling is a hallmark of RAC1 signaling. Recent work has uncovered a novel role of gamma-aminobutyric acid receptor-associated proteins (GABARAPs), a subfamily of human ATG8 ubiquitin-like modifiers, in providing a scaffold for recruitment of an ubiquitin E3 ligase complex to its substrate, T-lymphoma invasion and metastasis ...
Heide Marika, Genau, Christian, Behrends
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Skilgreining GABARAP ísoforma, Hlutverk og mikilvægi
, 2023 Autophagy is an essential degradation pathway in eukaryotic cells. It mediates the degradation of various materials such as proteins, mitochondria, parts of the endoplasmic reticulum and much more. Many genes are involved in the autophagy pathway and one
Þengill Fannar Jónsson 1996-
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Biology Open, 2014 We previously reported that phospholipase C-related catalytically inactive protein (PRIP)-knockout mice exhibited hyperinsulinemia. Here, we investigated the role of PRIP in insulin granule exocytosis using Prip-knockdown mouse insulinoma (MIN6) cells ...
Satoshi Asano +8 more
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Frontiers in Veterinary Science, 2022 Brown adipose tissue (BAT) is mainly present in young mammals and is important for maintaining body temperature in neonatal mammals because of its ability to produce non-shivering thermogenesis.
Le Zhao +5 more
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Expression of renal and intestinal Na/Pi cotransporters in the absence of GABARAP [PDF]
Pflügers Archiv - European Journal of Physiology, 2010 We have recently shown that the abundance of the renal sodium (Na)/inorganic phosphate (Pi) cotransporter NaPi-IIa is increased in the absence of the GABA(A) receptor-associated protein (GABARAP). Accordingly, GABARAP-deficient mice have a reduced urinary excretion of Pi.
Reining, S C +5 more
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A Conserved LIR Motif in Connexins Mediates Ubiquitin-Independent Binding to LC3/GABARAP Proteins
Cells, 2020 Gap junctions (GJ) are specialized cell-cell contacts formed by connexins (Cxs), which provide direct communication between adjacent cells. Cx43 ubiquitination has been suggested to induce the internalization of GJs, as well as the recruitment of the ...
Steve Catarino +6 more
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Author Correction: The highly GABARAP specific rat monoclonal antibody 8H5 visualizes GABARAP in immunofluorescence imaging at endogenous levels [PDF]
Scientific Reports, 2019 An amendment to this paper has been published and can be accessed via a link at the top of the paper.
Indra M. Simons +8 more
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Direct binding to GABARAP family members is essential for HIV-1 Nef plasma membrane localization
Scientific Reports, 2017 HIV-1 Nef is an important pathogenic factor for HIV/AIDS pathogenesis. Studies have shown that the association of Nef with the inner leaflet of the plasma membrane and with endocytic and perinuclear vesicles is essential for most activities of Nef. Using
Alexandra Boeske +8 more
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