Results 51 to 60 of about 10,328 (211)

NEAT1 Confers Radioresistance to Hepatocellular Carcinoma Cells by Inducing Autophagy through GABARAP [PDF]

International Journal of Molecular Sciences, 2022
A long noncoding RNA (lncRNA), nuclear enriched abundant transcript 1 (NEAT1) variant 1 (NEAT1v1), is involved in the maintenance of cancer stem cells (CSCs) in hepatocellular carcinoma (HCC). CSCs are suggested to play important roles in therapeutic resistance.
Hiromi Sakaguchi, Hiroyuki Tsuchiya, Yutaka Kitagawa, Tomohiko Tanino, Kenji Yoshida, Nobue Uchida, Goshi Shiota   +6 more
openaire   +2 more sources

Host-pathogen interactions and subversion of autophagy [PDF]

, 2017
Macroautophagy (“autophagy”), is the process by which cells can form a double membraned vesicle that encapsulates material to be degraded by the lysosome.
Alemu, Ali, Axe, Barnett, Baxt, Beale, Birmingham, Campbell, Cao, Case, Choy, David G. McEwan, de Jong, Diao, Dortet, Gaillard, Ganley, Gannage, Genau, Gutierrez, Habisov, Hailey, Hamasaki, Hanada, Hegedus, Horenkamp, Huett, Ikeda, Ikeda, Itakura, Jacomin, James T. Murray, Jennings, Joachim, Jon D. Lane, Khaminets, Kim, Kirisako, Kirkin, Kraft, Kreibich, Krick, Kuma, Kwon, Kyei, Lety, Li, Liu, Liu, Lu, Lystad, Maejima, Manzanillo, Matsunaga, Matsunaga, McEwan, Mira, Mohrluder, Moreau, Mostowy, Nakagawa, Nakatogawa, Newman, Noad, Noda, Noda, Novak, Ogawa, Olsvik, Pankiv, Pankiv, Petkova, Polson, Popovic, Ravikumar, Richetta, Rogov, Rogov, Russell, Schnaith, Slobodkin, Stolz, Taguchi-Atarashi, Takats, Thurston, Thurston, Thurston, Tsuboyama, Tumbarello, van der Vaart, van Wijk, van Wijk, Verlhac, Viktor I. Korolchuk, von Muhlinen, Watson, Weidberg, Wild, Yang, Yang, Yoshikawa, Yu, Zheng, Zhong, Zhou   +104 more
core   +2 more sources

Lipid Modulation of LC3/GABARAP-Mediated Autophagosomal Elongation [PDF]

Biophysical Journal, 2016
Autophagy, an important catabolic pathway involved in a broad spectrum of human diseases, implies the formation of double-membrane structures called autophagosomes (AP) which engulf material to be degraded in lytic compartments. How AP form, especially how the membrane expands and eventually closes upon itself is an area of intense research.
Alonso, Alicia, Landajuela, Ane, Hervas, Javier H., Anton, Zurine, Montes, L. Ruth, Gil, David, Valle, Mikel, Rodriguez, J. Francisco, Goni, Felix M.   +8 more
openaire   +1 more source

A Conserved LIR Motif in Connexins Mediates Ubiquitin-Independent Binding to LC3/GABARAP Proteins

Cells, 2020
Gap junctions (GJ) are specialized cell-cell contacts formed by connexins (Cxs), which provide direct communication between adjacent cells. Cx43 ubiquitination has been suggested to induce the internalization of GJs, as well as the recruitment of the ...
Steve Catarino, Teresa M Ribeiro-Rodrigues, Rita Sá Ferreira, José Ramalho, Christine Abert, Sascha Martens, Henrique Girão   +6 more
doaj   +1 more source

The autophagosome:current understanding of formation and maturation [PDF]

, 2015
Autophagy is an important and highly conserved catabolic process with roles in development, homeostasis, and cellular stress responses. It describes various distinct pathways for the delivery of cytoplasmic materials (including misfolded protein ...
Lane, Jon D, Mannack, Lilith V J
core   +2 more sources

Focused Design of Novel Cyclic Peptides Endowed with GABARAP-Inhibiting Activity

International Journal of Molecular Sciences, 2022
(1) Background: Disfunctions in autophagy machinery have been identified in various conditions, including neurodegenerative diseases, cancer, and inflammation. Among mammalian autophagy proteins, the Atg8 family member GABARAP has been shown to be greatly involved in the autophagy process of prostate cancer cells, supporting the idea that GABARAP ...
Enrico Mario Alessandro Fassi, Mariangela Garofalo, Jacopo Sgrignani, Michele Dei Cas, Matteo Mori, Gabriella Roda, Andrea Cavalli, Giovanni Grazioso   +7 more
openaire   +4 more sources

Exploring Arylidene-Indolinone Ligands of Autophagy Proteins LC3B and GABARAP. [PDF]

ACS Med Chem Lett
ABSTRACTWe report the first structure-activity studies of arylidene-indolinone compoundGW5074which was reported as a ligand of autophagy-related protein LC3B. The literature has conflicting information on the binding affinity of this compound and there is some debate regarding its use as a component of autophagy-dependent degrader compounds.
Leveille AN, Schwarzrock T, Brown H, True B, Plasencia J, Neudecker P, Üffing A, Weiergräber OH, Willbold D, Kritzer JA.   +9 more
europepmc   +5 more sources

In silico modeling of the Moniliophthora perniciosa Atg8 protein [PDF]

, 2013
Autophagy is defined as an intracellular system of lysosomal degradation in eukaryotic cells, and the genes involved in this process are conserved from yeast to humans.
Brendel, Martin, Cardoso, Thyago Hermylly Santana, Pereira, Alanna Cibelle Fernandes, Pungartnik, Cristina   +3 more
core   +2 more sources

A short isoform of ATG7 fails to lipidate LC3/GABARAP [PDF]

Scientific Reports, 2018
AbstractAutophagy is a degradation pathway important for cellular homeostasis. The E1-like enzyme ATG7 is a key component of the autophagy machinery, with the main function of mediating the lipidation of LC3/GABARAP during autophagosome formation. By analysing mRNA-sequencing data we found that in addition to the full-length ATG7 isoform, various ...
Ogmundsdottir, MH, Fock, Valerie, Sooman, L, Pogenberg, V, Dilshat, R, Bindesbøll, Christian, Ögmundsdóttir, Helga, Simonsen, Anne, Wilmanns, Matthias, Steingrimsson, E   +9 more
openaire   +4 more sources

The Carboxyl-Terminal Amino Acids Render Pro-Human LC3B Migration Similar to Lipidated LC3B in SDS-PAGE [PDF]

, 2013
LC3 is widely used marker for macroautophagy assays. After translation pro-LC3 is processed by Atg4 to expose C-terminal glycine residue for downstream conjugation reactions to accomplish the conversion of LC3-I to LC3-II. SDS-PAGE based Western blot (Wb)
Billiar, Timothy R., Chen, Zhixia, Gao, Wentao, Gasset, Maria, Stang, Michael T., Wang, Wei   +5 more
core   +6 more sources