Results 51 to 60 of about 7,891 (186)

Centrosome to autophagosome signaling: Specific GABARAP regulation by centriolar satellites [PDF]

Autophagy, 2017
Yeast have one Atg8 protein; however, multiple Atg8 orthologs (LC3s and GABARAPs) are found in humans. We discovered that a population of the Atg8 ortholog GABARAP resides on the centrosome and the peri-centrosomal region. This centrosomal pool of GABARAP translocates to forming autophagosomes upon starvation to activate autophagosome formation in a ...
Justin Joachim, Sharon A. Tooze
openaire   +2 more sources

E3 autophagy complex and LC3/GABARAP proteins in autophagosome generation [PDF]

, 2023
Trabajo presentado al 8th International Iberian Biophysics Congress celebrado en Bilbao los días 20 y 21 de junio de 2022.In macroautophagy, autophagosome (AP) formation in humans requires the concerted action of the LC3/GABARAP and ATG12 ubiquitin-like ...
Alonso, Alicia, Etxaniz, Asier, Lázaro, Melisa, Montes, L. Ruth, Valle, Mikel, Martens, Sasha, Ballesteros, Uxue, Iriondo, Marina N., Fracchiolla, Dorotea, Varela, Yaiza R., Goñi, Félix M.   +10 more
core  

Effect of ATG12–ATG5-ATG16L1 autophagy E3-like complex on the ability of LC3/GABARAP proteins to induce vesicle tethering and fusion [PDF]

, 2023
In macroautophagy, the autophagosome (AP) engulfs portions of cytoplasm to allow their lysosomal degradation. AP formation in humans requires the concerted action of the ATG12 and LC3/GABARAP conjugation systems. The ATG12–ATG5-ATG16L1 or E3-like complex
Alonso, Alicia, Lázaro, Melisa, Iriondo Nagore, Marina, Valle, Mikel, Montes Burgos, Lidia Ruth, Varela Fernández, Yaiza, Ballesteros, Uxue, Etxaniz Iriondo, Asier, Fracchiolla, Dorotea, Iriondo, Marina N., Martens, Sascha, Varela, Yaiza R., Goñi, Félix M., Alonso Izquierdo, Alicia, Etxaniz, Asier, Montes, L. Ruth, Ballesteros Rivero, Uxue, Goñi Urcelay, Félix María   +17 more
core   +1 more source

NEK9 regulates primary cilia formation by acting as a selective autophagy adaptor for MYH9/myosin IIA

Nature Communications, 2021
Ciliogenesis is a tightly regulated process, although the role of selective autophagy is unclear. Here, the authors show NIMA-related kinase 9 controls actin network stabilization and subsequently ciliogenesis by targeting myosin MYH9 for autophagic ...
Yasuhiro Yamamoto, Haruka Chino, Satoshi Tsukamoto, Koji L. Ode, Hiroki R. Ueda, Noboru Mizushima   +5 more
doaj   +1 more source

An atypical GABARAP binding module drives the pro-autophagic potential of the AML-associated NPM1c variant

Cell Reports, 2023
Summary: The nucleolar scaffold protein NPM1 is a multifunctional regulator of cellular homeostasis, genome integrity, and stress response. NPM1 mutations, known as NPM1c variants promoting its aberrant cytoplasmic localization, are the most frequent ...
Hannah Mende, Anshu Khatri, Carolin Lange, Sergio Alejandro Poveda-Cuevas, Georg Tascher, Adriana Covarrubias-Pinto, Frank Löhr, Sebastian E. Koschade, Ivan Dikic, Christian Münch, Anja Bremm, Lorenzo Brunetti, Christian H. Brandts, Hannah Uckelmann, Volker Dötsch, Vladimir V. Rogov, Ramachandra M. Bhaskara, Stefan Müller   +17 more
doaj   +1 more source

Phase Separation, Material State, and Condensate Fate in Mammalian Autophagy

Advanced Science, EarlyView.
ABSTRACT Biomolecular phase separation has emerged as a key organizing principle in macroautophagy (hereafter autophagy). In mammalian cells, phase‐separated condensates not only serve as substrates for selective degradation, but also act as dynamic platforms for cargo recognition, signaling integration, and autophagosome assembly.
Yuanqiang Lin, Mingran Dai, Enyong Dai, Rui Kang, Daniel J. Klionsky, Daolin Tang, Yu Sun, Ningning Lv, Junnan Jiang   +8 more
wiley   +1 more source

Identification of the GABARAP binding determinant in PI4K2A

Bioscience Reports
Abstract GABARAP is a member of the ATG8 family of ubiquitin-like autophagy related proteins. It was initially discovered as a facilitator of GABA-A receptor translocation to the plasma membrane and has since been shown to promote the intracellular transport of a variety of other proteins under non-autophagic conditions.
Chen, Yan, Barylko, Barbara, Eichorst, John P., Mueller, Joachim D., Albanesi, Joseph P.   +4 more
openaire   +2 more sources

Structure and potential functions of GABARAP

, 2009
The gamma-aminobutyrate type A receptor-associated protein (GABARAP) is a ubiquitin-like modifier, and is implicated in a variety of membrane trafficking and fusion events that are crucial to synaptic plasticity, autophagy and apoptosis.
Melanie Schwarten, Mohrlüder, J., Willbold, D., Dieter Willbold, Jeannine Mohrlüder, Schwarten, M.   +5 more
core   +1 more source

Highlighting the hidden: monitoring the avidity-driven association of a fluorescent GABARAP tandem with microtubules in living cells

Autophagy Reports
GABARAP, like other ATG8 proteins, is a ubiquitin-like modifier and its C-terminal lipid conjugation enables association with cellular membranes. To prevent interference with the lipidation process, N-terminal fluorescent protein (FP) tagging strategies ...
Alina Üffing, Lisa Gold, Thomas Gensch, Oliver H. Weiergräber, Silke Hoffmann, Dieter Willbold   +5 more
doaj   +1 more source

Exploring selective autophagy events in multiple biologic models using LC3-interacting regions (LIR)-based molecular traps

Scientific Reports, 2022
Autophagy is an essential cellular pathway that ensures degradation of a wide range of substrates including damaged organelles or large protein aggregates.
Grégoire Quinet, Pierre Génin, Oznur Ozturk, Naima Belgareh-Touzé, Lilas Courtot, Renaud Legouis, Robert Weil, Mickael M. Cohen, Manuel S. Rodriguez   +8 more
doaj   +1 more source