Results 61 to 70 of about 10,328 (211)

Induction of autophagy is a key component of all-trans-retinoic acid-induced differentiation in leukemia cells and a potential target for pharmacological modulation [PDF]

, 2015
Acute myeloid leukemia (AML) is characterized by the accumulation of immature blood cell precursors in the bone marrow. Pharmacologically overcoming the differentiation block in this condition is an attractive therapeutic avenue, which has achieved ...
Ablain, Adrian Britschgi, Brigger, Britschgi, Burnett, Cassinat, Chakrama, Chen, Choi, Conway, Crowley, Dos Santos, Elzinga, Feng, Finch, Focosi, Guan, Gupta, He, Humbert, Isakson, Jeanne, Jung, Kimura, Lihuan, Liu, Lo-Coco, Lorraine J. Gudas, Mario P. Tschan, Mary R. Cahill, Michelle J. Nyhan, Miller, Mizushima, Mizushima, Mortensen, Nasr, Nencioni, Nigel P. Mongan, Nina Orfali, Orfali, Pasquali, Quiroz, Renna, Sarkar, Shao, Sharon L. McKenna, Si, Sokoloski, Strohecker, Tang, Townsend, Tracey R. O'Donovan, Trocoli, Trocoli, Wang, Weidberg, White, Wu, Yousefi, Zhang, Zhang   +60 more
core   +1 more source

Direct binding to GABARAP family members is essential for HIV-1 Nef plasma membrane localization

Scientific Reports, 2017
HIV-1 Nef is an important pathogenic factor for HIV/AIDS pathogenesis. Studies have shown that the association of Nef with the inner leaflet of the plasma membrane and with endocytic and perinuclear vesicles is essential for most activities of Nef. Using
Alexandra Boeske, Melanie Schwarten, Peixiang Ma, Markus Tusche, Jessica Mötter, Christina Möller, Philipp Neudecker, Silke Hoffmann, Dieter Willbold   +8 more
doaj   +1 more source

Aberrant Autolysosomal Regulation Is Linked to The Induction of Embryonic Senescence: Differential Roles of Beclin 1 and p53 in Vertebrate Spns1 Deficiency [PDF]

, 2013
Spinster (Spin) in Drosophila or Spinster homolog 1 (Spns1) in vertebrates is a putative lysosomal H[superscript +]-carbohydrate transporter, which functions at a late stage of autophagy. The Spin/Spns1 defect induces aberrant autolysosome formation that
Bayliss, Peter E., Carr, Christopher E., Catz, Sergio D., Gill, Matthew, Guha, Sujay, Jia, Kailiang, Johnson, Jennifer L., Kishi, Shuji, Klionsky, Daniel J., Kobler, Patrick, Lian, Shanshan, Qi, Jie, Sasaki, Tomoyuki   +12 more
core   +4 more sources

Crystal structure of the GABA _A ‐receptor‐associated protein, GABARAP [PDF]

EMBO reports, 2002
The GABA A ‐receptor‐associated protein (GABARAP) is a member of a growing family of intracellular membrane trafficking and/or fusion proteins and has been implicated in plasma membrane targeting and/or recycling of GABA A receptors.
Bavro, V., Sola, M., Bracher, A., Kneussel, M., Betz, H., Weissenhorn, W.   +5 more
openaire   +4 more sources

NEK9 regulates primary cilia formation by acting as a selective autophagy adaptor for MYH9/myosin IIA

Nature Communications, 2021
Ciliogenesis is a tightly regulated process, although the role of selective autophagy is unclear. Here, the authors show NIMA-related kinase 9 controls actin network stabilization and subsequently ciliogenesis by targeting myosin MYH9 for autophagic ...
Yasuhiro Yamamoto, Haruka Chino, Satoshi Tsukamoto, Koji L. Ode, Hiroki R. Ueda, Noboru Mizushima   +5 more
doaj   +1 more source

An atypical GABARAP binding module drives the pro-autophagic potential of the AML-associated NPM1c variant

Cell Reports, 2023
Summary: The nucleolar scaffold protein NPM1 is a multifunctional regulator of cellular homeostasis, genome integrity, and stress response. NPM1 mutations, known as NPM1c variants promoting its aberrant cytoplasmic localization, are the most frequent ...
Hannah Mende, Anshu Khatri, Carolin Lange, Sergio Alejandro Poveda-Cuevas, Georg Tascher, Adriana Covarrubias-Pinto, Frank Löhr, Sebastian E. Koschade, Ivan Dikic, Christian Münch, Anja Bremm, Lorenzo Brunetti, Christian H. Brandts, Hannah Uckelmann, Volker Dötsch, Vladimir V. Rogov, Ramachandra M. Bhaskara, Stefan Müller   +17 more
doaj   +1 more source

Assessment of GABARAP self-association by its diffusion properties

Journal of Biomolecular NMR, 2010
Gamma-aminobutyric acid type A receptor-associated protein (GABARAP) belongs to a family of small ubiquitin-like adaptor proteins implicated in intracellular vesicle trafficking and autophagy. We have used diffusion-ordered nuclear magnetic resonance spectroscopy to study the temperature and concentration dependence of the diffusion properties of ...
Victor, Pacheco, Peixiang, Ma, Yvonne, Thielmann, Rudolf, Hartmann, Oliver H, Weiergräber, Jeannine, Mohrlüder, Dieter, Willbold   +6 more
openaire   +3 more sources

Exploring selective autophagy events in multiple biologic models using LC3-interacting regions (LIR)-based molecular traps

Scientific Reports, 2022
Autophagy is an essential cellular pathway that ensures degradation of a wide range of substrates including damaged organelles or large protein aggregates.
Grégoire Quinet, Pierre Génin, Oznur Ozturk, Naima Belgareh-Touzé, Lilas Courtot, Renaud Legouis, Robert Weil, Mickael M. Cohen, Manuel S. Rodriguez   +8 more
doaj   +1 more source

From Covalent Traps to Fluorescent Beacons: The Expanding Arsenal of Chemical Probes for Studying Ubiquitin and Ubiquitin‐Like Proteins

Angewandte Chemie, Volume 138, Issue 13, 23 March 2026.
A large variety of chemistry‐based ubiquitin probes have been developed. ABSTRACT Ubiquitin (Ub) and ubiquitin‐like proteins (Ubls) orchestrate diverse cellular processes through reversible post‐translational modification of target proteins. Their conjugation is governed by a cascade of E1 activating, E2 conjugating, and E3 ligating enzymes, while ...
Saibal Chanda, Wenshe Ray Liu
wiley   +2 more sources

Nigericin‐Triggered Phosphodynamics in Inflammasome Formation and Pyroptosis

PROTEOMICS, EarlyView.
ABSTRACT Innate immune signaling relies heavily on phosphorylation cascades to mount effective immune responses. Although traditional innate immune signaling cascades following TLR4 stimulation have been investigated through a temporally quantitative phosphoproteomic lens, far fewer studies have applied these methods to distinct signaling following the
Vanya Bhushan, Clinton J. Bradfield, Sandhini Saha, Sung Hwan Yoon, Iain D. C. Fraser, Aleksandra Nita‐Lazar   +5 more
wiley   +1 more source