Results 61 to 70 of about 7,891 (186)

MAPK15/ERK8 stimulates autophagy by interacting with LC3 and GABARAP proteins [PDF]

Autophagy, 2012
Macroautophagy (hereafter referred to as autophagy) is an evolutionarily conserved catabolic process necessary for normal recycling of cellular constituents and for appropriate response to cellular stress. Although several genes belonging to the core molecular machinery involved in autophagosome formation have been discovered, relatively little is ...
David Colecchia, Angela Strambi, Sveva Sanzone, Carlo Iavarone, Matteo Rossi, Claudia Dall'Armi, Federica Piccioni, Arturo Verrotti di Pianella, Mario Chiariello   +8 more
openaire   +3 more sources

Ciliary Type III Adenylyl Cyclase in the VMH Is Crucial for High‐Fat Diet‐Induced Obesity Mediated by Autophagy

Advanced Science, 2022
Neuronal primary cilia are crucial for body weight maintenance. Type III adenylyl cyclase (AC3) is abundantly enriched in neuronal cilia, and mice with global AC3 ablation are obese.
Dong Yang, Xiangbo Wu, Weina Wang, Yanfen Zhou, Zhenshan Wang   +4 more
doaj   +1 more source

Decoding neuronal vulnerability: Multidimensional analysis of D1R‐ and D2R‐ medium‐sized spiny neurons in Huntington's disease

Brain Pathology, EarlyView.
D1R and D2R MSNs show distinct responses to Huntington's pathology. G&T‐sequencing of pre‐symptomatic MSNs reveals global LINE‐1 downregulation. While D1R‐MSNs display early transcriptomic changes (OXPHOS/translation upregulation) and reduced mutant huntingtin aggregation, D2R‐MSNs exhibit higher nuclear mHTT accumulation and greater CAG somatic ...
Guendalina Bergonzoni, Miguel Pellegrini, Aurora Savino, Martina Lazioli, Sarah Geurs, Lorenzo Graziani, Denise Ferrarini, Solaleh Khoramian Tusi, Esaria Oliver, Jarne Geurts, Sara Vinciguerra, Michele Tebaldi, Takshashila Tripathi, Isabella Pesce, Valeria Poli, Alessandro Romanel, Rosario Moratalla, Thierry Voet, Jasmin Morandell, Remo Sanges, Vanessa C. Wheeler, Erik Dassi, Marta Biagioli   +22 more
wiley   +1 more source

Comobility of GABARAP and Phosphatidylinositol 4-Kinase 2A on Cytoplasmic Vesicles [PDF]

Biochemistry, 2018
We previously reported that recruitment of the type IIA phosphatidylinositol 4-kinase (PI4K2A) to autophagosomes by GABARAP, a member of the Atg8 family of autophagy-related proteins, is important for autophagosome-lysosome fusion. Because both PI4K2A and GABARAP have also been implicated in the intracellular trafficking of plasma membrane receptors in
Yan Chen, Hui-Qiao Sun, John P. Eichorst, Joseph P. Albanesi, Helen Yin, Joachim D. Mueller   +5 more
openaire   +2 more sources

Structural characterization and interaction studies of ubiquitin-like proteins [PDF]

, 2011
Ubiquitin is a highly conserved protein involved in several cellular processes like protein degradation, endocytosis, signal transduction and DNA repair. The discovery of ubiquitin-like proteins (UBL) and ubiquitin-like domains (ULD) increases the number
Rozenknop, Alexis
core  

Aging of Skeletal Muscle: From Molecular Mechanisms to Therapeutic Interventions

MedComm, Volume 7, Issue 10, October 2026.
Skeletal muscle aging is driven by coordinated local breakdown across myofibers, stem and stromal cells, immune and vascular compartments, and neuromuscular control. These mechanisms promote mitochondrial dysfunction, inflammation, senescence, impaired regeneration, fibrosis, myosteatosis, denervation, and functional decline.
Ting Liu, Yaomin Hu
wiley   +1 more source

Centriolar satellites control GABARAP ubiquitination and GABARAP-mediated autophagy

, 2020
Autophagy maintains cellular health and homeostasis during stress by delivering cytosolic material captured by autophagosomes to lysosomes for degradation.
Delphine Judith (164433), Minoo Razi (459364), Nicola O'Reilly (230098), Harold BJ Jefferies (8128491), Martina Wirth (3832903), Emily Calamita (9260504), Sharon A Tooze (8114291), Justin Joachim (7429253), Ambrosius P Snijders (8119406), Vesela Encheva (4917094), Brian D Dynlacht (7953554)   +10 more
core  

Targeting the DNA Damage Response in Cancer

MedComm, Volume 7, Issue 10, October 2026.
Targeting the DNA damage response (DDR) reshapes both tumor vulnerability and antitumor immunity. DNA lesions and DDR inhibitors can promote cytosolic nucleic‐acid sensing, antigen presentation, and immune activation, but can also induce adaptive immune escape.
Yihuan Qiao, Boyu Kang, Jian Zhang, Rui Zhang, Jipeng Li   +4 more
wiley   +1 more source

Structure-Based Design of Stapled Peptides That Bind GABARAP and Inhibit Autophagy [PDF]

, 2022
The LC3/GABARAP family of proteins are involved in nearly every stage of autophagy. Inhibition of LC3/GABARAP proteins is a promising approach to blocking autophagy, which sensitizes advanced cancers to DNA-damaging chemotherapy.
Lu, Zhen, Kritzer, Joshua A, Brown, Hawley, Chung, Mia, Kritzer, Joshua A., Zhen Lu, Oliver H. Weiergräber, Bast, Robert C, Tiffany Tsang, Batistatou, Nefeli, Joshua A. Kritzer, Robert C. Bast, Üffing, Alina, Hawley Brown, Mao, Weiqun, Samantha Doskocil, Weiergräber, Oliver H, Mia Chung, Doskocil, Samantha, Willbold, Dieter, Bast, Robert C., Nefeli Batistatou, Weiergräber, Oliver H., Tsang, Tiffany, Alina Üffing, Dieter Willbold, Weiqun Mao   +26 more
core   +1 more source

Molecular determinants regulating selective binding of autophagy adapters and receptors to ATG8 proteins

Nature Communications, 2019
Autophagy adaptors and receptors contain LC3-interacting region (LIR) motifs that bind selectively to the LIR docking site of GABARAP and other members of the ATG8 family. Here the authors show that in addition to the LIR motif also the region C-terminal
Martina Wirth, Wenxin Zhang, Minoo Razi, Lynet Nyoni, Dhira Joshi, Nicola O’Reilly, Terje Johansen, Sharon A. Tooze, Stéphane Mouilleron   +8 more
doaj   +1 more source