Results 81 to 90 of about 7,891 (186)
iScience, 2020 Summary: USP14 is a deubiquitinating enzyme associated with the proteasome important for protein degradation. Here we show that upon proteasome inhibition or expression of the mutant W58A-USP14, association of USP14 with the 19S regulatory particle is ...
Vignesh Srinivasan +6 more
doaj +1 more source
The FASEB Journal, Volume 40, Issue 14, 31 July 2026.The Graphical Abstract demonstrates our research approach. Use GEO database to screen differentially expressed genes (DEGs), and weighted gene co expression network analysis (WGCNA) to identify ubiquitination related gene modules. The LASSO logistic regression and support vector machine recursive feature elimination (SVM‐RFE) algorithm is used to ...
Ting Dong +4 more
wiley +1 more source
The study of roles of Gabarap in inflammatory responses [PDF]
, 2012 在神经元细胞中，γ-氨基丁酸A受体结合蛋白（GABAAreceptor-associatedprotein，Gabarap）能够参与γ-氨基丁酸A受体（GABAAreceptor）的转运及其突触后的定位。Gabarap在许多组织和器官中广泛表达，但对其生理功能仍然不太清楚。 在此，我们通过建立小鼠败血症（Sepsis）模型来研究Gabarap在调节免疫反应过程中的作用。研究结果显示，Gabarap敲除小鼠对败血症引起的死亡敏感性增强；Gabarap缺失败血症小鼠体内促炎症细胞因子的含量升高 ...
张志荣
core
Molecules, 2019 Subcellular structures containing autophagy-related proteins of the Atg8 protein family have been investigated with conventional wide-field fluorescence and single molecule localisation microscopy.
Iman Abdollahzadeh +7 more
doaj +1 more source
The ubiquitin‐proteasome system and autophagy as guardians of the cellular proteome
FEBS Letters, Volume 600, Issue 13, Page 1829-1841, July 2026.This Perspective covers the three principles governing the crosstalk between the ubiquitin‐proteasome system and autophagy in cellular proteostasis: (1) a shared ubiquitin code routing substrates via shuttle factors or autophagy receptors; (2) spatial compartmentalization into phase‐separated degradation hubs and organelle‐specific modules (exemplified
Ivan Dikic
wiley +1 more source
AlphaFold2‐Guided Cyclic Peptide Stabilizer Design to Target Protein–Protein Interactions
Proteins: Structure, Function, and Bioinformatics, Volume 94, Issue 7, Page 1356-1370, July 2026.ABSTRACT The control and modulation of protein–protein interactions (PPIs) is of central importance for the majority of biological processes and most biomedical applications. Stabilization of PPIs, besides inhibition, is of growing pharmaceutical interest.
Niklas Halbwedl, Martin Zacharias
wiley +1 more source
Genes to Cells, Volume 31, Issue 4, July 2026.WT SQSTM1 binds to polyubiquitinated cargo and recruits both the cargo and itself to the autophagy‐endolysosomal system (left). In contrast, a fraction of the L341V variant fails to be recruited to autophagosomes and instead forms ubiquitin‐positive large structures (right).
Kento Shimakura +5 more
wiley +1 more source
Chronic Diseases and Translational Medicine, Volume 12, Issue 2, Page 126-138, June 2026.High‐resolution single‐cell atlas of normal gastric tissue, primary gastric cancer, and metastatic lesions. (A) Schematic diagram of experimental design. (B) Bar plot for qualified cell numbers in each lesion. (C) Cells annotation by canon markers for all cells. (D) Bubble chart for canon marker genes for each cell subtype.
Min Sun +3 more
wiley +1 more source
Gene Deletion of Gabarap Enhances Nlrp3 Inflammasome-Dependent Inflammatory Responses [PDF]
, 2013 Natural Science Foundation of China [91029304, 30830092, 31221065, 81061160512]; 973 Program [2009CB522200]; 111 Project [B12001]; Open Research Fund of State Key Laboratory of Cellular Stress Biology, Xiamen University [SKLCSB2012KF003]The gamma ...
王彦海 +8 more
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CNS Neuroscience &Therapeutics, Volume 32, Issue 6, June 2026.Our study reveals that the reversible changes in memory impairment and recovery following sevoflurane with dynamic changes of expression and distribution of α5‐GABAAR. Memory impairment is associated with the upregulation of α5‐GABAAR expression and postsynaptic distribution on day 2 after sevoflurane exposure.
Sixuan Wang +13 more
wiley +1 more source