Results 101 to 110 of about 10,328 (211)
Molecules, 2019 Subcellular structures containing autophagy-related proteins of the Atg8 protein family have been investigated with conventional wide-field fluorescence and single molecule localisation microscopy.
Iman Abdollahzadeh +7 more
doaj +1 more source
iScience, 2020 Summary: USP14 is a deubiquitinating enzyme associated with the proteasome important for protein degradation. Here we show that upon proteasome inhibition or expression of the mutant W58A-USP14, association of USP14 with the 19S regulatory particle is ...
Vignesh Srinivasan +6 more
doaj +1 more source
Ankyrin-G regulates forebrain connectivity and network synchronization via interaction with GABARAP [PDF]
Molecular Psychiatry, 2018 GABAergic circuits are critical for the synchronization and higher order function of brain networks. Defects in this circuitry are linked to neuropsychiatric diseases, including bipolar disorder, schizophrenia, and autism. Work in cultured neurons has shown that ankyrin-G plays a key role in the regulation of GABAergic synapses on the axon initial ...
A. D. Nelson +15 more
openaire +3 more sources
Autophagosome marker, LC3, is released extracellularly via several distinct pathways
FEBS Open Bio, Volume 16, Issue 3, Page 542-560, March 2026.This study establishes a novel HiBiT‐tagging system for ultrasensitive detection of LC3, revealing multiple pathways for its extracellular secretion. It demonstrates that LC3 is released via both autophagy‐dependent and ‐independent mechanisms, including a novel route for nonlipidated LC3‐I.
Koki Saito +3 more
wiley +1 more source
Strategy of macromolecular grafting onto a gold substrate dedicated to protein-protein interaction measurements. [PDF]
, 2006 International audienceMany biotechnology applications use proteins immobilized on surface. For biosensor, the sensing layer is a key component interfacing the transducer and the sample.
Boireau, Wilfrid +3 more
core +3 more sources
Advanced Science, Volume 13, Issue 16, 18 March 2026.Phosphorylation of Optineurin by TBK1 induces the formation of filaments that condensate upon binding to linear polyubiquitin. Membrane‐anchored LC3 partitions into these condensates, suggesting that phase separation of filamentous Optineurin with ubiquitylated cargo promotes the sequestration of cargo and its subsequent alignment with LC3‐positive ...
Maria G. Herrera +10 more
wiley +1 more source
Caspase involvement in autophagy [PDF]
, 2017 Caspases are a family of cysteine proteases widely known as the principal mediators of the apoptotic cell death response, but considerably less so as the contributors to the regulation of pathways outside cellular demise.
A Gross +114 more
core +1 more source
A 47-Year Old Female with Muscular Rigidity, New-Onset Diabetes and Hypothyroidism [PDF]
, 2013 Background This case highlights a rare but devastating neurologic condition, Stiff Person Syndrome (SPS). While symptoms of muscular rigidity andspasms areassocia ted with numerous neuromuscular conditions, the association between SPS, autoimmune ...
Valentino, MD, PhD, Michael A.
core +2 more sources
Comobility of GABARAP and Phosphatidylinositol 4-Kinase 2A on Cytoplasmic Vesicles [PDF]
Biochemistry, 2018 We previously reported that recruitment of the type IIA phosphatidylinositol 4-kinase (PI4K2A) to autophagosomes by GABARAP, a member of the Atg8 family of autophagy-related proteins, is important for autophagosome-lysosome fusion. Because both PI4K2A and GABARAP have also been implicated in the intracellular trafficking of plasma membrane receptors in
Yan Chen +5 more
openaire +2 more sources
Advanced Science, Volume 13, Issue 16, 18 March 2026.Metastatic invasion emerges when tumor‐intrinsic programs and microenvironmental forces converge on mitochondrial quality control. A context‐stratified framework links mtROS, mtDNA integrity, mechanics and nutrient/oxygen cues to fission–fusion remodeling, mtUPR and mitophagy.
Bin‐Hsu Mao +3 more
wiley +1 more source