Results 101 to 110 of about 7,891 (186)

Exploring Arylidene–Indolinone Ligands of Autophagy Proteins LC3B and GABARAP

ACS Medicinal Chemistry Letters
ABSTRACT We report the first structure-activity studies of arylidene-indolinone compound GW5074 which was reported as a ligand of autophagy-related protein LC3B. The literature has conflicting information on the binding affinity of this compound and there is some debate regarding ...
Leveille, Alexandria N., Schwarzrock, Thomas, Brown, Hawley, True, Bennett, Plasencia, Joanet, Neudecker, Philipp, Üffing, Alina, Weiergräber, Oliver H., Willbold, Dieter, Kritzer, Joshua A.   +9 more
openaire   +4 more sources

Metformin Impairs Glutamine Metabolism and Autophagy in Tumour Cells

Cells, 2019
Metformin has been shown to inhibit glutaminase (GLS) activity and ammonia accumulation thereby reducing the risk of hepatic encephalopathy in type 2 diabetic patients.
Serena Saladini, Michele Aventaggiato, Federica Barreca, Emanuela Morgante, Luigi Sansone, Matteo A. Russo, Marco Tafani   +6 more
doaj   +1 more source

Investigation of GABARAP complexes with apoptosis-related proteins and structural characterization of GABARAP lipidation

, 2011
Autophagy is a bulky protein degradation mechanism to maintain cellular homeostasis. The first decisive event in autophagy is the formation of autophagosomes, double-membrane vesicles responsible for delivering cytoplasmic material to lysosomes.
Ma, peixiang
core  

GFP-GABARAP colocalizes with ankyrin-G and MAP2.

, 2013
(A–H) The pyramidal neurons of the CA1 region of the hippocampus (A–D) and cerebellar Purkinje cells (E–H) of GFP-GABARAP transgenic mice were stained with antibodies to GFP (green), ankyrin-G (red) and MAP2 (blue).
Yasuo Uchiyama (209045), Masato Koike (209042), Isei Tanida (411585), Takashi Ueno (411589), Tomohisa Nanao (411586), Norihiro Tada (411587), Eiki Kominami (411590), Jun-ichi Iwata (411588)   +7 more
core   +1 more source

Apolipoprotein L9 interacts with LC3/GABARAP and is a microtubule-associated protein with a widespread subcellular distribution

Biology Open, 2019
Mouse Apolipoprotein L9 is a 34-kDa phosphatidylethanolamine (PE)-binding protein. The gene is present only in mouse and rat genomes; hence it is restricted to two species.
Arvind A. Thekkinghat, Kamlesh K. Yadav, Pundi N. Rangarajan   +2 more
doaj   +1 more source

Structure of GABARAP in Two Conformations [PDF]

Neuron, 2002
Coyle, Joseph E., Qamar, Seema, Rajashankar, Kanagalaghatta R., Nikolov, Dimitar B.   +3 more
openaire   +1 more source

Plasmodium berghei liver stage parasites exploit host GABARAP proteins for TFEB activation

Communications Biology
Plasmodium, the causative agent of malaria, infects hepatocytes prior to establishing a symptomatic blood stage infection. During this liver stage development, parasites reside in a parasitophorous vacuole (PV), whose membrane acts as the critical ...
Jacqueline Schmuckli-Maurer, Annina F. Bindschedler, Rahel Wacker, Oliver M. Würgler, Ruth Rehmann, Timothy Lehmberg, Leon O. Murphy, Thanh N. Nguyen, Michael Lazarou, Jlenia Monfregola, Andrea Ballabio, Volker T. Heussler   +11 more
doaj   +1 more source

Human ATG4 autophagy proteases counteract attachment of ubiquitin-like LC3/GABARAP proteins to other cellular proteins [PDF]

, 2019
Microtubule-associated protein 1 light chain 3 alpha (LC3)/GABA type A receptor–associated protein (GABARAP) comprises a family of ubiquitin-like proteins involved in (macro)autophagy, an important intracellular degradation pathway that delivers ...
Von Chamier, L, Agrotis, A, Oliver, H, Singh, T, Ketteler, R, Kiso, K   +5 more
core   +1 more source

The double role of GABAergic system in systemic tumors: an updated review

Frontiers in Oncology
The GABAergic system is the main inhibitory nervous system. In addition, GABA has been reported to affect tumor growth and its expression differs between tumor tissue and normal tissue.
Xueyang Yang, Qianhe Zu, Luxuan Wang, Chunhui Li, Lijian Zhang, Lijian Zhang   +5 more
doaj   +1 more source

Identification of clathrin heavy chain as a direct binding partner for the GABA type A receptor associated protein GABARAP

, 2007
Gamma-aminobutyric acid type A receptors (GABAA receptors) are the major sites of GABA-mediated fast synaptic inhibition in the central nervous system.
Hänel, K., Mohrlüder, J., Willbold, D., Stangler, T., Hoffmann, Y.   +4 more
core   +1 more source