Results 91 to 100 of about 7,891 (186)

GABARAP sequesters the FLCN-FNIP tumor suppressor complex to couple autophagy with lysosomal biogenesis

, 2021
Adaptive changes in lysosomal capacity are driven by the transcription factors TFEB and TFE3 in response to increased autophagic flux and endolysosomal stress, yet the molecular details of their activation are unclear. LC3 and GABARAP members of the ATG8
Garcia-Fortanet J., Baird D., Agrawal A., Fletcher K., Walkup W. G., Ng A., Brumell J. H., Appleton B. A., Hooper K., Lehmberg T., Tang Q., Florey O., Budhe S. R., Saunders J., Ballabio A., Li T., Jha A., Goodwin J. M., Rouduri S. R., Murphy L. O., Kishi-Itakura C., Wei M., Chance M. R., Kommineni S., Fan Y., Kiselar J.   +25 more
core   +1 more source

GABARAP activates ULK1 and traffics from the centrosome dependent on Golgi partners WAC and GOLGA2/GM130

, 2020
WAC and GOLGA2/GM130 are 2 Golgi proteins that affect autophagy; however, their mechanism of action was unknown. We have shown that WAC binding to GOLGA2 at the Golgi displaces GABARAP from GOLGA2 to allow the maintenance of a nonlipidated centrosomal ...
Sharon A Tooze (8114291), Justin Joachim (7429253)   +1 more
core  

Starvation conditions have little effect on GFP-GABARAP expression in the heart, liver and skeletal muscle.

, 2013
(A) Expression of GFP-GABARAP in tissues of GFP-GABARAP transgenic mice. Cell lysates were immunoblotted with anti-GFP antibody to detect GFP-GABARAP. Endogenous GABARAP and LC3 were detected with anti-GABARAP and anti-LC3 antibodies, respectively. Arrow-
Yasuo Uchiyama (209045), Masato Koike (209042), Isei Tanida (411585), Takashi Ueno (411589), Tomohisa Nanao (411586), Norihiro Tada (411587), Eiki Kominami (411590), Jun-ichi Iwata (411588)   +7 more
core   +1 more source

A conserved ATG2-GABARAP interaction is critical for phagophore closure [PDF]

, 2019
Abstract The intracellular trafficking pathway, macroautophagy, acts as a recycling and disposal service that can be upregulated during periods of stress, to maintain cellular homeostasis. An essential transition point in the pathway is the sealing of the immature phagophore to form an autophagosome, isolating unwanted cargo prior to ...
Bozic, Mihaela, van den Bekerom, Luuk, Milne, Beth A., Goodman, Nicola, Roberston, Lisa, Prescott, Alan R., Macartney, Thomas J., Dawe, Nina, McEwan, David G.   +8 more
openaire   +1 more source

Identification of Kinases and Phosphatases That Regulate ATG4B Activity by siRNA and Small Molecule Screening in Cells

Frontiers in Cell and Developmental Biology, 2018
Autophagy protease ATG4B is a key regulator of the LC3/GABARAP conjugation system required for autophagosome formation, maturation and closure. Members of the ATG4 and the LC3/GABARAP family have been implicated in various diseases including cancer, and ...
Niccolo Pengo, Krisna Prak, Joana R. Costa, Christin Luft, Alexander Agrotis, Jamie Freeman, Christina A. Gewinner, A. W. Edith Chan, David L. Selwood, Janos Kriston-Vizi, Robin Ketteler   +10 more
doaj   +1 more source

Analysis of differential expression of GABARAP family members in Glioblastoma

Our study is based on the analysis of the differential expression of GABARAP family members in glioblastoma (GBM). We investigated the expression of GABARAP’s (GABARAP, GABARAPL1, and GABARAPL2) and MAP1LC3’s (MAP1LC3A, MAP1LC3B, and MAP1LC3C) in GBM ...
Bissa, Bhawana
core   +1 more source

Identification of calreticulin as ligand of GABARAP by phage display screening of a peptide library [PDF]

, 2007
4-Aminobutyrate type A (GABA(A)) receptor-associated protein (GABARAP) is a ubiquitin-like modifier implicated in the intracellular trafficking of GABA(A) receptors, and belongs to a family of proteins involved in intracellular vesicular transport ...
Mataruga, A., Mohrlüder, J., Willbold, D., Wiesehan, K., Stangler, T., Hoffmann, Y.   +5 more
core   +1 more source

NS1 binding protein regulates stress granule dynamics and clearance by inhibiting p62 ubiquitination

Nature Communications
The NS1 binding protein, known for interacting with the influenza A virus protein, is involved in RNA processing, cancer, and nerve cell growth regulation. However, its role in stress response independent of viral infections remains unclear.
Pureum Jeon, Hyun-Ji Ham, Haneul Choi, Semin Park, Jae-Woo Jang, Sang-Won Park, Dong-Hyung Cho, Hyun-Jeong Lee, Hyun Kyu Song, Masaaki Komatsu, Dohyun Han, Deok-Jin Jang, Jin-A Lee   +12 more
doaj   +1 more source

Regulation of GABAA-Receptor Surface Expression With Special Reference to the Involvement of GABARAP (GABAA Receptor-Associated Protein) and PRIP (Phospholipase C-Related, but Catalytically Inactive Protein)

Journal of Pharmacological Sciences, 2007
GABAA receptors are heteropentameric ligand-gated chloride channels composed of a variety of subunits, including α1 – 6, β1 – 3, γ1 – 3, δ, ε, θ, and π, and play a key role in controlling inhibitory neuronal activity.
Takashi Kanematsu, Akiko Mizokami, Keiko Watanabe, Masato Hirata   +3 more
doaj   +1 more source

Conjugation of GABARAP to ATG9A Compartments v1

This protocol describes the conjugation of GABARAP to ATG9A Compartments.
Elisabeth Holzer, Justyna Sawa-Makarska
openaire   +1 more source