Results 91 to 100 of about 10,328 (211)

A switch element in the autophagy E2 Atg3 mediates allosteric regulation across the lipidation cascade

, 2019
Autophagy depends on the E2 enzyme, Atg3, functioning in a conserved E1-E2-E3 trienzyme cascade that catalyzes lipidation of Atg8-family ubiquitin-like proteins (UBLs).
Grace, C., Klionsky, D., Liu, X., Qiu, Y., Schulman, B., Zheng, Y.   +5 more
core   +1 more source

Receptor proteins in selective autophagy [PDF]

, 2012
Autophagy has long been thought to be an essential but unselective bulk degradation pathway. However, increasing evidence suggests selective autophagosomal turnover of a broad range of substrates.
Behrends, Christian, Fulda, Simone
core   +1 more source

Axon Initial Segment: Structure, Biological Functions, Diseases, and Therapeutic Targets

MedComm, Volume 7, Issue 4, April 2026.
The axon initial segment (AIS) is a specialized axonal domain critical for maintaining neuronal polarity, action potential initiation, and network stability. This review summarizes the necessary elements for maintaining AIS structure and plasticity, discussing crucial biological functions of AIS in neuronal signaling and the neural circuit homeostasis,
Dong‐Yan Song, Lin Yuan, Weiguo Yang, Wen Li, Jia‐Yi Li   +4 more
wiley   +1 more source

Expression of renal and intestinal Na/Pi cotransporters in the absence of GABARAP [PDF]

, 2018
We have recently shown that the abundance of the renal sodium (Na)/inorganic phosphate (Pi) cotransporter NaPi-IIa is increased in the absence of the GABAA receptor-associated protein (GABARAP).
Betz, Heinrich, Biber, Jürg, Hernando, Nati, Liesegang, Annette, Murer, Heini, Reining, Sonja   +5 more
core  

Advances in autophagy regulatory mechanisms [PDF]

, 2016
Autophagy plays a critical role in cell metabolism by degrading and recycling internal components when challenged with limited nutrients. This fundamental and conserved mechanism is based on a membrane trafficking pathway in which nascent autophagosomes ...
Chan, Edmond Y. W., Gallagher, Laura E., Williamson, Leon E.   +2 more
core   +2 more sources

Clinically relevant GABARAP deficiency abrogates bortezomib-induced immunogenic cell death in multiple myeloma

OncoImmunology
Recently, it was revealed that the high-risk, poor-prognosis downregulation of GABA type A receptor-associated protein (GABARAP) causes a defect in both autophagy and surface exposure of calreticulin (CALR) in multiple myeloma (MM) cells responding to ...
Liwei Zhao, Zhe Shen, Guido Kroemer, Oliver Kepp   +3 more
doaj   +1 more source

Herpesvirus lytic infection-induced mitophagy via viral interferon regulatory factor 1

Autophagy Reports, 2023
Viral control of mitochondria via mitophagy has a dampening effect on mitochondrion-mediated innate immune responses. We previously found that human herpesvirus 8 (HHV-8) could activate mitophagy via its lytic gene product vIRF-1 (viral interferon ...
Mai Tram Vo, Young Bong Choi
doaj   +1 more source

Newly identified properties of known pharmaceuticals and myxobacterial small molecules revealed by screening for autophagy modulators

The FEBS Journal, Volume 293, Issue 8, Page 2314-2340, April 2026.
Autophagy is a cellular degradation process involved in, for example, immune responses to pathogens and neurodegeneration. To identify modulators of autophagy, we developed a microscopy‐based screening assay and identified previously unknown autophagy‐modulating activities in known drugs and natural products from myxobacteria and fungi.
Janine Fichtner, Yan Yan Beer, H. G. Mauricio Ramm, Sabrina Mühlen, Frank Surup, Jennifer Herrmann, Toni Luise Meister, Stephanie Pfaender, Ursula Bilitewski, Mark Brönstrup, Rolf Müller, Manfred Wirth, Eeva‐Liisa Eskelinen, Ingo Schmitz   +13 more
wiley   +1 more source

NaPi-IIa interacting proteins and regulation of renal reabsorption of phosphate [PDF]

, 2018
Control of phosphate (Pi) homeostasis is essential for many biologic functions and inappropriate low levels of Pi in plasma have been suggested to associate with several pathological states, including renal stone formation and stone recurrence.
Biber, Jürg, Capuano, Paola, Déliot, Nadine, Gisler, Serge, Hernando, Nati, Murer, Heini, Reining, Sonja   +6 more
core  

CCPG1 Is a Non-canonical Autophagy Cargo Receptor Essential for ER-Phagy and Pancreatic ER Proteostasis [PDF]

, 2018
Mechanisms of selective autophagy of the ER, known as ER-phagy, require molecular delineation, particularly in vivo. It is unclear how these events control ER proteostasis and cellular health.
Adamson, Alain J. Kemp, Alex von Kriegsheim, Antonucci, Axe, B'Chir, Behrends, Chen, Christian Behrends, Cox, Deosaran, Di Bartolomeo, Diakopoulos, Dunlop, Edwards, Egan, Farré, Fracchiolla, Fumagalli, Gammoh, Ganley, Ge, Grasso, Grumati, Hailey, Hamasaki, Hara, Hashimoto, Hayashi-Nishino, Heo, Hess, Hosokawa, Houck, Huh, Huttlin, Ichimura, Itakura, Jia, Jimi Wills, Joo, Jung, Kamber, Khaminets, Khaminets, Kim, Kostenko, Kraft, Ktistakis, Lazarou, Lee, Lin, Lipatova, Liu, Longatti, Lum, Maejima, Mali, Margaret E. Harley, Mark Arends, Martin Lee, Matthew D. Smith, Mizushima, Mochida, Newman, Newman, Nguyen, Ogata, Pankiv, Pengo, Ran, Ravikumar, Rouschop, Russell, Simon Wilkinson, Slobodkin, Sowa, Teckman, Thurston, Tian, Tooze, Tooze, Torggler, Tsuboyama, Wang, Wild, Wisniewski, Wong, Zheng   +87 more
core   +1 more source