Results 111 to 120 of about 7,891 (186)

Mechanisms and roles of membrane-anchored ATG8s

Frontiers in Cell and Developmental Biology
Autophagy-related protein 8 (ATG8) family proteins, including LC3 and GABARAP subfamilies, are pivotal in canonical autophagy, driving autophagosome formation, cargo selection, and lysosomal fusion.
Soo-Kyeong Lee, Sang-Won Park, Deok-Jin Jang, Jin-A. Lee   +3 more
doaj   +1 more source

Die Lösungsstruktur des humanen GABA-A-Rezeptor-assoziierten Proteins GABARAP

, 2002
The GABA$_{A}$-receptor-associated protein (GABARAP) is a member of a family of intracellular membrane trafficking and fusion proteins and has been implicated in postsynaptic membrane targeting of GABA$_{A}$ receptors and modulation of GABAergic synapses.
Stangler, T.
core  

GABARAP interacts with EGFR — supporting the unique role of this hAtg8 protein during receptor trafficking

The human Atg8 family member GABARAP is involved in numerous autophagy-related and -unrelated processes. We recently observed that specifically the deficiency of GABARAP enhances epidermal growth factor receptor (EGFR) degradation upon ligand stimulation.
Weiergräber, Oliver H., Üffing, Alina, Schwarten, Melanie, Hoffmann, Silke, Willbold, Dieter   +4 more
core   +1 more source

Lack of GABARAP-Type Proteins Is Accompanied by Altered Golgi Morphology and Surfaceome Composition

, 2020
GABARAP (γ-aminobutyric acid type A receptor-associated protein) and its paralogues GABARAPL1 and GABARAPL2 comprise a subfamily of autophagy-related Atg8 proteins. They are studied extensively regarding their roles during autophagy. Originally, however,
Üffing, Alina, Simons, Indra M., Indra M. Simons, Hoffmann, Silke, Willbold, Dieter, Kai Stühler, Dobner, Jochen, Silke Hoffmann, Stühler, Kai, Jochen Dobner, Alina Üffing, Dieter Willbold, Sanwald, Julia L., Julia L. Sanwald, Poschmann, Gereon, Gereon Poschmann   +15 more
core   +1 more source

GABAA receptor associated protein (GABARAP) modulates TRPV1 expression and channel function and desensitization.

, 2010
Transient receptor potential vanilloid (TRPV1) transduces noxious chemical and physical stimuli in high-threshold nociceptors. The pivotal role of TRPV1 in the physiopathology of pain transduction has thrust the identification and characterization of ...
I. Ontoria Oviedo, VALENTE, PIERLUIGI, M. Camprubí Robles, Planells-Cases, R., Valente, P., R. Planells Cases, Ferrer-Montiel, A., A. Ferrer Montiel, Estevez-Herrera, J., S. Laínez, Lainez, S., Ontoria-Oviedo, I., Camprubi-Robles, M., J. Estévez Herrera   +13 more
core   +1 more source

Creatine and retinoic acid effects on the induction of autophagy and differentiation of adipose tissue-derived stem cells into GABAergic-like neurons

Majallah-i Dānishgāh-i ̒Ulūm-i Pizishkī-i Bābul, 2017
BACKGROUND AND OBJECTIVE: Deficit of inhibitory GABAergic neurons as a part of central nervous system (CNS) pathogenesis was reported in neurodegenerative disorders; and adipose-derived stem cells (ADSCs) were shown to be a feasible option for cell ...
Sh Darabi, T Tiraihi, A Noori-zadeh, F Rajaei, L Darabi, H Abbaszadeh   +5 more
doaj  

Identifizierung von physiologischen und artifiziellen Liganden von GABARAP und Charakterisierung der resultierenden Interaktionen [PDF]

, 2008
$\gamma$-aminobutyric acid (GABA) receptors (type A) (GABA$_{A}$ receptors) mediate fast synaptic inhibition in the central nervous system. They are of particular pharmacological importance and are targets for drugs used to treat mental disorders or to ...
Mohrlüder, Jeannine
core  

LC3 and GABARAP independent autophagy of misfolded procollagen in mouse osteoblasts

Autophagy
Bone synthesis should depend on autophagy because over 10% of type I procollagen (PC1) – a heterotrimer of COL1A1 and COL1A2 chains and the precursor of the main bone matrix molecule – is misfolded and rerouted from osteoblast endoplasmic reticulum (ER) to lysosomes.
Elena Makareeva, Shakib Omari, Anna M. Roberts-Pilgrim, Laura Gorrell, Bella Radant, Muthulakshmi Sellamani, Edward L. Mertz, Basma Khoury, Kenneth Kozloff, Sergey Leikin   +9 more
openaire   +2 more sources

ER-phagy restrains inflammatory responses through its receptor UBAC2

The EMBO Journal
ER-phagy, a selective form of autophagic degradation of endoplasmic reticulum (ER) fragments, plays an essential role in governing ER homeostasis. Dysregulation of ER-phagy is associated with the unfolded protein response (UPR), which is a major clue for
Xing He, Haowei He, Zitong Hou, Zheyu Wang, Qinglin Shi, Tao Zhou, Yaoxing Wu, Yunfei Qin, Jun Wang, Zhe Cai, Jun Cui, Shouheng Jin   +11 more
doaj   +1 more source

Biochemical investigation of LC3/GABARAP-ligand interaction as an important quality measure for LC3/GABARAP-targeting small molecules: addendum to the guidelines (4th edition)

Autophagy
Targeted protein degradation (TPD) represents a new therapeutic modality that allows the targeting of proteins that are considered undruggable by conventional small molecules. While TPD approaches via the ubiquitin-proteasome system are well established and validated, additional degradation pathways still require rigorous characterization.
Martin P. Schwalm, Christopher Lenz, Krishna Saxena, Daniel J. Klionsky, Ewgenij Proschak, Stefan Knapp   +5 more
openaire   +3 more sources