Results 111 to 120 of about 10,328 (211)

Differentiation state-specific mitochondrial dynamic regulatory networks are revealed by global transcriptional analysis of the developing chicken lens. [PDF]

, 2014
The mature eye lens contains a surface layer of epithelial cells called the lens epithelium that requires a functional mitochondrial population to maintain the homeostasis and transparency of the entire lens.
Anastas, Sara, Basu, Subhasree, Brennan, Lisa A., Chauss, Daniel, Gau, Victoria, Hejtmancik, J. Fielding, Kantorow, Marc, Ma, Zhiwei, Menko, A. Sue, Rajakaruna, Suren   +9 more
core   +3 more sources

Editorial : Autophagy : from big data to physiological significance [PDF]

, 2020
Autophagy is a fundamental catabolic process where cytoplasmic components are sequestered into double-membrane vesicles called autophagosomes, which then fuse with lysosomes and their content is degraded.
Nezis, Ioannis P., Sarkar, Sovan, Vaccaro, Maria I.   +2 more
core   +1 more source

Membralin Assembles a MAN1B1–VCP Complex to Target Foreign Glycoproteins from the Endoplasmic Reticulum to Lysosomes for Degradation

Advanced Science, Volume 13, Issue 9, 13 February 2026.
This study identifies Membralin as an ER‐phagy receptor that recruits MAN1B1 and VCP to form a selective ERLAD complex. By sensing dense N‐glycan clusters on viral fusion glycoproteins, this ubiquitin‐independent pathway directs SARS‐CoV‐2 spike, Ebola GP, influenza HA, and HIV‐1 Env to lysosomal degradation, thereby limiting viral infectivity ...
Jing Zhang, Xiaoran Lu, Sunan Li, Tao Wang, Iqbal Ahmad, Yong‐Hui Zheng   +5 more
wiley   +1 more source

Regulation of autophagy‐mediated pathways by diet, physical activity, and sleep in Alzheimer's disease

Alzheimer's &Dementia, Volume 22, Issue 2, February 2026.
Abstract Alzheimer's disease (AD) is a progressive, age‐related, neurodegenerative disorder marked by cognitive decline, memory loss, and accumulation of amyloid beta (Aβ) plaques and tau tangles. A key feature of AD is impaired protein homeostasis, often driven by autophagy dysfunction.
Ajish Ariyath, Zoe Mputhia, Christopher Dougherty, Bushra Kaleelur Rahuman, W. M. A. D. Binosha Fernando, Belinda Brown, Samantha L. Gardener, Stephanie R. Rainey‐Smith, Ralph Martins, Prashant Bharadwaj   +9 more
wiley   +1 more source

The regulation of the autophagic network and its implications for human disease [PDF]

, 2013
Autophagy has attracted a lot of attention in recent years. More and more proteins and signaling pathways have been discovered that somehow feed into the autophagy regulatory pathways.
Carra, Serena, Kampinga, Harm H., Yang, Jing, Zhu, Wei Guo   +3 more
core   +2 more sources

p62/SQSTM1 Condensation Modulates Mitochondrial Clustering to Participate in Mitochondrial Quality Control

Aging Cell, Volume 25, Issue 2, February 2026.
In normal PINK1/Parkin‐mediated mitophagy, unlike OPTN (the mitophagy receptor that mediates ATG8‐labeled autophagosome recruitment onto ubiquitinated mitochondria), p62 mediates the clustering of ubiquitinated mitochondria to form the “grape‐like” aggregates with ubiquitin.
Shan Sun, Jiaqi Xin, Yingping Zhang, Bojun Yang, Dan Su, Rui Ni, Qilian Ma, Ningning Li, Guoqiang Ma, Qiang Peng, Siqian Chen, Jochen H. M. Prehn, Kin Yip Tam, Hongfeng Wang, Zheng Ying   +14 more
wiley   +1 more source

GABA(A) receptor phospho-dependent modulation is regulated by phospholipase C-related inactive protein type 1, a novel protein phosphatase 1 anchoring protein [PDF]

, 2004
GABA(A) receptors are critical in controlling neuronal activity. Here, we examined the role for phospholipase C-related inactive protein type 1 (PRIP-1), which binds and inactivates protein phosphatase 1alpha (PP1alpha) in facilitating GABA(A) receptor ...
Akaike, N, Ha, SH, Hirata, M, Jang, IS, Jovanovic, JN, Kanematsu, T, Kittler, JT, Moss, SJ, Nakayama, KI, Ryu, SH, Terunuma, M   +10 more
core  

The protective role of pregnane X receptor in lipopolysaccharide/D-galactosamine-induced acute liver injury. [PDF]

, 2010
The pregnane X receptor (PXR) is a nuclear receptor transcription factor regulating drug-metabolizing enzymes and transporters that facilitate xenobiotic and endobiotic detoxification.
Damjanov, Ivan, Wan, Yu-Jui Yvonne, Wang, Kun   +2 more
core   +2 more sources

Autophagy and cancer [PDF]

, 2014
Autophagy is an evolutionary conserved intracellular degradation and stress response mechanism that is mainly responsible for the breakdown and recycling of cytoplasmic materials, including long-lived proteins, protein aggregates, and damaged organelles.
Gozuacik, Devrim, Gözüaçık, Devrim, Karakas, Hacer Ezgi, Karakaş, Hacer Ezgi   +3 more
core   +1 more source

The mammalian ULK1 complex and autophagy initiation [PDF]

, 2017
Autophagy is a vital lysosomal degradation pathway that serves as a quality control mechanism. It rids the cell of damaged, toxic or excess cellular components, which if left to persist could be detrimental to the cell.
Bach, Bento, Chan, Chan, Chauhan, Chen, Cheong, Chude, Di Bartolomeo, Dunlop, Egan, Egan, Farre, Fullgrabe, Gammoh, Gan, Gan, Ganley, Henckaerts, Hieke, Hosokawa, Hosokawa, Ian G. Ganley, Itakura, James T. Murray, Jiang, Jon D. Lane, Joo, Jung, Kaizuka, Kaizuka, Karanasios, Karanasios, Kim, Konno, Koyama-Honda, Kundu, Lamark, Lazarou, Lazarus, Lee, Li, Li, Li, Li, Lim, Lin, Lin, Liu, Liu, Maria Zachari, McWilliams, Mercer, Nazio, Nazio, Ochaba, Orsi, Pengo, Petherick, Pickrell, Pike, Puente, Puri, Qi, Rabanal-Ruiz, Rui, Russell, Sarraf, Schneider, Sellier, Su, Sun, Suzuki, Tian, Torii, Ugolino, Viktor I. Korolchuk, Wang, Webster, Wold, Wong, Wu, Xu, Yang, Young, Yun, Zhou, Zou   +87 more
core   +2 more sources