Results 131 to 140 of about 10,328 (211)

Neurotransmitter-gated ion channels at fast chemical synapses: from structure to pathology [PDF]

, 2005
Fil: Bouzat, Cecilia Beatriz. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Instituto de Investigaciones Bioquímicas de Bahía Blanca. Universidad Nacional del Sur.
Bouzat, Cecilia Beatriz
core  

Morbus Crohn—a disease of failing macroautophagy in the immune system? [PDF]

, 2017
Mutations in genes involved in macroautophagy have been found to be associated with Morbus Crohn, also called Crohn's disease (CD), an inflammatory bowel disease.
Meixlsperger, Sonja, Münz, Christian
core  

Structure of GABARAP in Two Conformations [PDF]

Neuron, 2002
Coyle, Joseph E., Qamar, Seema, Rajashankar, Kanagalaghatta R., Nikolov, Dimitar B.   +3 more
openaire   +1 more source

Creatine and retinoic acid effects on the induction of autophagy and differentiation of adipose tissue-derived stem cells into GABAergic-like neurons

Majallah-i Dānishgāh-i ̒Ulūm-i Pizishkī-i Bābul, 2017
BACKGROUND AND OBJECTIVE: Deficit of inhibitory GABAergic neurons as a part of central nervous system (CNS) pathogenesis was reported in neurodegenerative disorders; and adipose-derived stem cells (ADSCs) were shown to be a feasible option for cell ...
Sh Darabi, T Tiraihi, A Noori-zadeh, F Rajaei, L Darabi, H Abbaszadeh   +5 more
doaj  

Generation of Atg4A deficient cells through the use of CRISPR/Cas9 technology and analysis of the consequences of Atg4A loss in autophagy pathway [PDF]

La autofagia constituye un importante mecanismo de protección que permite a las células sobrevivir en respuesta a múltiples factores estresantes. Dentro de los genes implicados en la autofagia, conocidos como genes Atg, el sistema proteolítico Atg4-Atg8 ...
Jiménez Alduán, Nelia
core  

ER-phagy restrains inflammatory responses through its receptor UBAC2

The EMBO Journal
ER-phagy, a selective form of autophagic degradation of endoplasmic reticulum (ER) fragments, plays an essential role in governing ER homeostasis. Dysregulation of ER-phagy is associated with the unfolded protein response (UPR), which is a major clue for
Xing He, Haowei He, Zitong Hou, Zheyu Wang, Qinglin Shi, Tao Zhou, Yaoxing Wu, Yunfei Qin, Jun Wang, Zhe Cai, Jun Cui, Shouheng Jin   +11 more
doaj   +1 more source

Biochemical investigation of LC3/GABARAP-ligand interaction as an important quality measure for LC3/GABARAP-targeting small molecules: addendum to the guidelines (4th edition)

Autophagy
Targeted protein degradation (TPD) represents a new therapeutic modality that allows the targeting of proteins that are considered undruggable by conventional small molecules. While TPD approaches via the ubiquitin-proteasome system are well established and validated, additional degradation pathways still require rigorous characterization.
Martin P. Schwalm, Christopher Lenz, Krishna Saxena, Daniel J. Klionsky, Ewgenij Proschak, Stefan Knapp   +5 more
openaire   +3 more sources

Loss of GABARAP mediates resistance to immunogenic chemotherapy in multiple myeloma

Blood
Abstract Immunogenic cell death (ICD) is a form of cell death by which cancer treatments can induce a clinically relevant antitumor immune response in a broad range of cancers. In multiple myeloma (MM), the proteasome inhibitor bortezomib is an ICD inducer and creates durable therapeutic responses in patients ...
Annamaria Gulla, Eugenio Morelli, Megan Johnstone, Marcello Turi, Mehmet K. Samur, Cirino Botta, Selma Cifric, Pietro Folino, Delaney Vinaixa, Francesca Barello, Cole Clericuzio, Vanessa Katia Favasuli, Domenico Maisano, Srikanth Talluri, Rao Prabhala, Giada Bianchi, Mariateresa Fulciniti, Kenneth Wen, Keiji Kurata, Jiye Liu, Johany Penailillo, Alberto Bragoni, Anna Sapino, Paul G. Richardson, Dharminder Chauhan, Ruben D. Carrasco, Teru Hideshima, Nikhil C. Munshi, Kenneth C. Anderson   +28 more
openaire   +4 more sources

First person – Arvind Thekkinghat

Biology Open, 2019
First Person is a series of interviews with the first authors of a selection of papers published in Biology Open, helping early-career researchers promote themselves alongside their papers.
doaj   +1 more source

High-Throughput Screening for LC3/GABARAP Binders Utilizing the Fluorescence Polarization Assay

The characterization of interactions between autophagy modifiers (Atg8-family proteins) and their natural ligands (peptides and proteins) or small molecules is important for a detailed understanding of selective autophagy mechanisms and for the design of potential Atg8 inhibitors that affect the autophagy processes in cells.
Schwalm, Martin P., Dopfer, Johannes, Knapp, Stefan, Rogov, Vladimir V.   +3 more
openaire   +4 more sources