Results 121 to 130 of about 7,891 (186)

Loss of GABARAP mediates resistance to immunogenic chemotherapy in multiple myeloma

Blood
Abstract Immunogenic cell death (ICD) is a form of cell death by which cancer treatments can induce a clinically relevant antitumor immune response in a broad range of cancers. In multiple myeloma (MM), the proteasome inhibitor bortezomib is an ICD inducer and creates durable therapeutic responses in patients ...
Annamaria Gulla, Eugenio Morelli, Megan Johnstone, Marcello Turi, Mehmet K. Samur, Cirino Botta, Selma Cifric, Pietro Folino, Delaney Vinaixa, Francesca Barello, Cole Clericuzio, Vanessa Katia Favasuli, Domenico Maisano, Srikanth Talluri, Rao Prabhala, Giada Bianchi, Mariateresa Fulciniti, Kenneth Wen, Keiji Kurata, Jiye Liu, Johany Penailillo, Alberto Bragoni, Anna Sapino, Paul G. Richardson, Dharminder Chauhan, Ruben D. Carrasco, Teru Hideshima, Nikhil C. Munshi, Kenneth C. Anderson   +28 more
openaire   +4 more sources

Activation of ULK kinase and autophagy by GABARAP trafficking from the centrosome is regulated by WAC and GM130

, 2020
Starvation-induced autophagy requires activation of the ULK complex at the phagophore. Two Golgi proteins, WAC and GM130, regulate autophagy, however their mechanism of regulation is unknown.
Delphine Judith (164433), Harold BJ Jefferies (8128491), Minoo Razi (459364), Sharon A Tooze (8114291), Justin Joachim (7429253), David Frith (7584005), Probir Chakravarty (755948), Ambrosius P Snijders (8119406)   +7 more
core  

Role of gamma aminobutyric acid A receptor associated protein (GABARAP) in the podocytes of GABARAP Tg mice

Juntendo Medical Journal, 2011
TAKAGI, MIYUKI, ASANUMA, KATSUHIKO, TANIDA, ISEI, TOMINO, YASUHIKO   +3 more
openaire   +2 more sources

Discovering host-viral protein interactions in autophagy: A LIR discovery pipeline for identifying LC3-interacting region motifs in highly virulent viruses. [PDF]

PLoS Pathog
Petraccione KD, Wahba HM, Ali MGH, Stocker T, Akhrymuk I, Swese Y, Sastre D, Silberfarb A, O'Maille PE, Omichinski JG, Kehn-Hall K.   +10 more
europepmc   +1 more source

Crystal structures of NSs4 in complex with LC3A and GABARAP.

(A) Cartoon representation of the crystal structure of the NSs4-LC3A complex highlighting the side chains of NSs4 (firebrick red) when bound to LC3A (forest green).
Paul O’Maille (18196747), Raphaël Cafaro (18196741), Normand Cyr (8897279), Kaylee Petraccione (18196726), Nicole Bracci (8259813), James Omichinski (6059414), Kylene Kehn-Hall (45085), Danuta Sastre (5074088), Ivan Akhrymuk (2934816), Lauren Panny (10481461), Andrew Silberfarb (18196744), Mohamed G. H. Ali (18196729), Haytham M. Wahba (18196732), Timothy Stocker (18196735), Maryna Akhrymuk (18196738)   +14 more
core   +1 more source

Research advances in key genes and regulatory mechanisms of posttranslational modifications in Parkinson's disease. [PDF]

PLoS One
Wang B, Huang Z, Wang R, Zhu C, Ma S, Wang M.   +5 more
europepmc   +1 more source

Early-Life High-Fat Diet Impairs Autophagy and Reduces GABA_A Receptor Expression in Hypothalamic Neurons, Promoting Depressive-like Behaviors in Offspring Mice. [PDF]

Nutrients
Qian M, Doubra O, Su Y, Bai S, Zhou H, Li H, Yan D, Gao L.   +7 more
europepmc   +1 more source

Minimal <i>N</i>-methylated and stapled peptide inhibitors of the autophagy protein GABARAP. [PDF]

RSC Chem Biol
McDonald I, Wilms JA, Cardi N, Engstrom A, Miao J, Willbold D, Lin YS, Lokey RS, Weiergräber OH, Kritzer JA.   +9 more
europepmc   +1 more source

GABA_A Receptor Trafficking Disruption in Epilepsy: From Assembly to Synaptic Dysfunction. [PDF]

Synapse
Mohammadpour T, Mohammadzadeh R.
europepmc   +1 more source

HFGuidedDesign: <i>de novo</i> design of cyclic peptide binders <i>via</i> structure-guided discrete diffusion. [PDF]

Chem Sci
Hu H, Zhu R, Zhu N, Zhang C, Shang T, Li C, Guo J, Wang X, Duan H.   +8 more
europepmc   +1 more source