Results 121 to 130 of about 10,328 (211)

Identification of Kinases and Phosphatases That Regulate ATG4B Activity by siRNA and Small Molecule Screening in Cells

Frontiers in Cell and Developmental Biology, 2018
Autophagy protease ATG4B is a key regulator of the LC3/GABARAP conjugation system required for autophagosome formation, maturation and closure. Members of the ATG4 and the LC3/GABARAP family have been implicated in various diseases including cancer, and ...
Niccolo Pengo, Krisna Prak, Joana R. Costa, Christin Luft, Alexander Agrotis, Jamie Freeman, Christina A. Gewinner, A. W. Edith Chan, David L. Selwood, Janos Kriston-Vizi, Robin Ketteler   +10 more
doaj   +1 more source

Autophagy: A cyto-protective mechanism which prevents primary human hepatocyte apoptosis during oxidative stress [PDF]

, 2012
The role of autophagy in the response of human hepatocytes to oxidative stress remains unknown. Understanding this process may have important implications for the understanding of basic liver epithelial cell biology and the responses of hepatocytes ...
Biederbick A, Christopher J. Weston, David H. Adams, Munafo´ DB, Ricky H. Bhogal, Schroedl C, Simon C. Afford, Stuart M. Curbishley   +7 more
core   +1 more source

NS1 binding protein regulates stress granule dynamics and clearance by inhibiting p62 ubiquitination

Nature Communications
The NS1 binding protein, known for interacting with the influenza A virus protein, is involved in RNA processing, cancer, and nerve cell growth regulation. However, its role in stress response independent of viral infections remains unclear.
Pureum Jeon, Hyun-Ji Ham, Haneul Choi, Semin Park, Jae-Woo Jang, Sang-Won Park, Dong-Hyung Cho, Hyun-Jeong Lee, Hyun Kyu Song, Masaaki Komatsu, Dohyun Han, Deok-Jin Jang, Jin-A Lee   +12 more
doaj   +1 more source

Regulation of GABAA-Receptor Surface Expression With Special Reference to the Involvement of GABARAP (GABAA Receptor-Associated Protein) and PRIP (Phospholipase C-Related, but Catalytically Inactive Protein)

Journal of Pharmacological Sciences, 2007
GABAA receptors are heteropentameric ligand-gated chloride channels composed of a variety of subunits, including α1 – 6, β1 – 3, γ1 – 3, δ, ε, θ, and π, and play a key role in controlling inhibitory neuronal activity.
Takashi Kanematsu, Akiko Mizokami, Keiko Watanabe, Masato Hirata   +3 more
doaj   +1 more source

Small GTPases as regulators of cell division [PDF]

, 2013
The superfamily of small GTPases serves as a signal transducer to regulate a diverse array of cellular functions. The members of this superfamily are structurally and functionally classified into at least 5 groups (Ras, Rho/Rac, Rab, Arf, and Ran) and ...
Colombo, Maria Isabel, Militello, Rodrigo Damián   +1 more
core   +1 more source

Large scale statistical analysis of GEO datasets [PDF]

, 2014
The problem addressed here is that of simultaneous treatment of several gene expression datasets, possibly collected under different experimental conditions and/or platforms.
Charmpi, Konstantina, Fournié, Jean-Jacques, Rousseaux, Sophie, Ycart, Bernard   +3 more
core   +3 more sources

Metformin Impairs Glutamine Metabolism and Autophagy in Tumour Cells

Cells, 2019
Metformin has been shown to inhibit glutaminase (GLS) activity and ammonia accumulation thereby reducing the risk of hepatic encephalopathy in type 2 diabetic patients.
Serena Saladini, Michele Aventaggiato, Federica Barreca, Emanuela Morgante, Luigi Sansone, Matteo A. Russo, Marco Tafani   +6 more
doaj   +1 more source

Uterine selection of human embryos at implantation [PDF]

, 2014
Human embryos frequently harbor large-scale complex chromosomal errors that impede normal development. Affected embryos may fail to implant although many first breach the endometrial epithelium and embed in the decidualizing stroma before being rejected ...
A Mertzanidou, B Cloke, B Crespi, BC Han, BM Forman, CH Weimar, D Emera, D Emera, D Haig, DM Benbrook, E Rajcan-Separovic, E Vanneste, EB Chuong, EM Heijnen, FU Hartl, G Teklenburg, GW Wong, H Yang, HH Kampinga, JJ Brosens, JJ Brosens, LA Kazal, M Furuhashi, M Iwaki, M Ohmuraya, M Salker, MD Stephenson, MS Salker, MS Salker, N Arimura, N Mansouri-Attia, N Sharma, N Sharma, NS Macklon, P Walter, R Rai, S Altmae, S Kaushik, S Quenby, T Iwawaki, T Kadowaki, Y Kabeya, YC Ruan, YH Yang, YJ Kim   +44 more
core   +2 more sources

Apolipoprotein L9 interacts with LC3/GABARAP and is a microtubule-associated protein with a widespread subcellular distribution

Biology Open, 2019
Mouse Apolipoprotein L9 is a 34-kDa phosphatidylethanolamine (PE)-binding protein. The gene is present only in mouse and rat genomes; hence it is restricted to two species.
Arvind A. Thekkinghat, Kamlesh K. Yadav, Pundi N. Rangarajan   +2 more
doaj   +1 more source

Plasmodium berghei liver stage parasites exploit host GABARAP proteins for TFEB activation

Communications Biology
Plasmodium, the causative agent of malaria, infects hepatocytes prior to establishing a symptomatic blood stage infection. During this liver stage development, parasites reside in a parasitophorous vacuole (PV), whose membrane acts as the critical ...
Jacqueline Schmuckli-Maurer, Annina F. Bindschedler, Rahel Wacker, Oliver M. Würgler, Ruth Rehmann, Timothy Lehmberg, Leon O. Murphy, Thanh N. Nguyen, Michael Lazarou, Jlenia Monfregola, Andrea Ballabio, Volker T. Heussler   +11 more
doaj   +1 more source