Results 31 to 40 of about 10,328 (211)
Development of GABARAP family protein-sensitive LIR-based probes for neuronal autophagy
Molecular Brain, 2019 Autophagy allows for lysosomal cellular degradation of cytosolic components. In particular, neuronal autophagy is essential for cellular homeostasis and neuronal survival and is tightly regulated by several autophagy-related (ATG) proteins in post ...
Pureum Jeon +5 more
doaj +1 more source
iLIR : a web resource for prediction of Atg8-family interacting proteins [PDF]
, 2014 Macroautophagy was initially considered to be a nonselective process for bulk breakdown of cytosolic material. However, recent evidence points toward a selective mode of autophagy mediated by the so-called selective autophagy receptors (SARs).
Johansen, Terje +6 more
core +1 more source
Author Correction: The highly GABARAP specific rat monoclonal antibody 8H5 visualizes GABARAP in immunofluorescence imaging at endogenous levels [PDF]
Scientific Reports, 2019 An amendment to this paper has been published and can be accessed via a link at the top of the paper.
Indra M. Simons +8 more
openaire +2 more sources
Doryphagy: when selective autophagy safeguards centrosome integrity
Molecular & Cellular Oncology, 2020 Although centrosome abnormalities are frequent in cancer, the mechanisms responsible for their accumulation are poorly understood. Here we comment on our recent publication identifying a new type of selective autophagy, named doryphagy, which preserves ...
Valentina Cianfanelli, Francesco Cecconi
doaj +1 more source
Nature Communications, 2021 The GABARAP protein is known to support the stability of GABAA receptors (GABAARs) in synapses, but the underlying molecular mechanisms remained to be elucidated.
Jin Ye +8 more
doaj +1 more source
eLife, 2023 Autophagy is an essential catabolic pathway which sequesters and engulfs cytosolic substrates via autophagosomes, unique double-membraned structures. ATG8 proteins are ubiquitin-like proteins recruited to autophagosome membranes by lipidation at the C ...
Wenxin Zhang +8 more
doaj +1 more source
Inhibition of GABARAP or GABARAPL1 prevents aminoglycoside- induced hearing loss. [PDF]
Proc Natl Acad Sci U S AAminoglycosides (AGs) are highly potent, broad-spectrum antibiotics frequently used as first-line treatments for multiple life-threatening infections. Despite their severe ototoxicity, causing irreversible hearing loss in millions of people annually, no preventive therapy has been approved.
Li J, Oh SI, Liu C, Zhao B.
europepmc +3 more sources
Tumor suppression in mice lacking GABARAP, an Atg8/LC3 family member implicated in autophagy, is associated with alterations in cytokine secretion and cell death [PDF]
, 2016 GABARAP belongs to an evolutionary highly conserved gene family that has a fundamental role in autophagy. There is ample evidence for a crosstalk between autophagy and apoptosis as well as the immune response.
Al-Saadi, K. R. D. +11 more
core +1 more source
Autophagy processes are dependent on EGF receptor signaling [PDF]
, 2018 Autophagy is a not well-understood conserved mechanism activated during nutritional deprivation in order to maintain cellular homeostasis. In the present study, we investigated the correlations between autophagy, apoptosis and the MAPK pathways in ...
Capodifoglio, Sabrina +12 more
core +1 more source
Frontiers in Immunology, 2020 Sepsis is a life-threating multi-organ disease induced by host innate immunity to pathogen-derived endotoxins including lipopolysaccharide (LPS). Direct sensing of LPS by caspase-11 activates inflammasomes and causes lethal sepsis in mice.
Naoya Sakaguchi +12 more
doaj +1 more source