Results 31 to 40 of about 7,891 (186)

A functional analysis of GABARAP on 17p13.1 by knockdown zebrafish [PDF]

Journal of Human Genetics, 2010
Array-based comparative genomic hybridization identified a 2.3-Mb microdeletion of 17p13.2p13.1 in a boy presenting with moderate mental retardation, intractable epilepsy and dysmorphic features. This deletion region was overlapped with the previously proposed shortest region overlapped for microdeletion of 17p13.1 in patients with mental retardation ...
Yuta, Komoike, Keiko, Shimojima, Jao-Shwann, Liang, Hiroshi, Fujii, Yoshihiro, Maegaki, Makiko, Osawa, Sakiko, Fujii, Toru, Higashinakagawa, Toshiyuki, Yamamoto   +8 more
openaire   +2 more sources

A STING-CASM-GABARAP Pathway Activates LRRK2 at Lysosomes

Journal of Cell Biology, 2023
Abstract Mutations that increase LRRK2 kinase activity have been linked to Parkinson’s disease and Crohn’s disease. LRRK2 is also activated by lysosome damage. However, the endogenous cellular mechanisms that control LRRK2 kinase activity are not well understood.
Amanda Bentley-DeSousa, Agnes Roczniak-Ferguson, Shawn M. Ferguson   +2 more
openaire   +2 more sources

GABARAPs regulate PI4P-dependent autophagosome:lysosome fusion [PDF]

Proceedings of the National Academy of Sciences, 2015
Significance Autophagy is an essential homeostatic process that is critically important for maintaining health and that is dysregulated in multiple devastating diseases. The steps in the final stages of autophagy that culminate in autophagosome:lysosome fusion are not well understood.
Hanzhi, Wang, Hui-Qiao, Sun, Xiaohui, Zhu, Li, Zhang, Joseph, Albanesi, Beth, Levine, Helen, Yin   +6 more
openaire   +2 more sources

GABARAP ameliorates IL-1β-induced inflammatory responses and osteogenic differentiation in bone marrow-derived stromal cells by activating autophagy

Scientific Reports, 2021
Bone mesenchymal stem cells (BMSCs) are the most commonly investigated progenitor cells in bone defect repair and osteoarthritis subchondral bone regeneration; however, these studies are limited by complex inflammatory conditions.
Xiaobo Guo, Zhenyuan Wu
doaj   +1 more source

LGG-1/GABARAP lipidation is not required for autophagy and development in Caenorhabditis elegans

eLife, 2023
The ubiquitin-like proteins Atg8/LC3/GABARAP are required for multiple steps of autophagy, such as initiation, cargo recognition and engulfment, vesicle closure and degradation.
Romane Leboutet, Céline Largeau, Leonie Müller, Magali Prigent, Grégoire Quinet, Manuel S Rodriguez, Marie-Hélène Cuif, Thorsten Hoppe, Emmanuel Culetto, Christophe Lefebvre, Renaud Legouis   +10 more
doaj   +1 more source

Doryphagy: when selective autophagy safeguards centrosome integrity

Molecular & Cellular Oncology, 2020
Although centrosome abnormalities are frequent in cancer, the mechanisms responsible for their accumulation are poorly understood. Here we comment on our recent publication identifying a new type of selective autophagy, named doryphagy, which preserves ...
Valentina Cianfanelli, Francesco Cecconi
doaj   +1 more source

Structural basis of GABARAP-mediated GABAA receptor trafficking and functions on GABAergic synaptic transmission

Nature Communications, 2021
The GABARAP protein is known to support the stability of GABAA receptors (GABAARs) in synapses, but the underlying molecular mechanisms remained to be elucidated.
Jin Ye, Guichang Zou, Ruichi Zhu, Chao Kong, Chenjian Miao, Mingjie Zhang, Jianchao Li, Wei Xiong, Chao Wang   +8 more
doaj   +1 more source

GABARAP deficiency modulates expression of NaPi-IIa in renal brush-border membranes [PDF]

, 2009
Renal reabsorption of inorganic phosphate (P(i)) is mainly mediated by the Na(+)-dependent P(i)-cotransporter NaPi-IIa that is expressed in the brush-border membrane (BBM) of renal proximal tubules.
Biber, Jürg, Heini Murer, Betz, H, Hernando, N., Hernando, N, Murer, H., O'Sullivan, G A, Reining, S, O'Sullivan, G., Nati Hernando, Fuster, D., Serge M. Gisler, O'Sullivan, Gregory A, Betz, Heinrich, Reining, Sonja C, Gisler, S., Moe, O., Daniel Fuster, Jürg Biber, Murer, H, Orson W. Moe, Gisler, Serge M, Betz, H., Gisler, S M, Reining, S., Gregory A. O'Sullivan, Heinrich Betz, Fuster, D, Sonja C. Reining, Biber, J, Moe, O, Biber, J., Moe, Orson W, Hernando, Nati, Fuster, Daniel Guido, Murer, Heini   +35 more
core   +1 more source

Autophagosome membrane expansion is mediated by the N-terminus and cis-membrane association of human ATG8s

eLife, 2023
Autophagy is an essential catabolic pathway which sequesters and engulfs cytosolic substrates via autophagosomes, unique double-membraned structures. ATG8 proteins are ubiquitin-like proteins recruited to autophagosome membranes by lipidation at the C ...
Wenxin Zhang, Taki Nishimura, Deepanshi Gahlot, Chieko Saito, Colin Davis, Harold BJ Jefferies, Anne Schreiber, Lipi Thukral, Sharon A Tooze   +8 more
doaj   +1 more source

A short isoform of ATG7 fails to lipidate LC3/GABARAP [PDF]

Scientific Reports, 2018
AbstractAutophagy is a degradation pathway important for cellular homeostasis. The E1-like enzyme ATG7 is a key component of the autophagy machinery, with the main function of mediating the lipidation of LC3/GABARAP during autophagosome formation. By analysing mRNA-sequencing data we found that in addition to the full-length ATG7 isoform, various ...
Ogmundsdottir, MH, Fock, Valerie, Sooman, L, Pogenberg, V, Dilshat, R, Bindesbøll, Christian, Ögmundsdóttir, Helga, Simonsen, Anne, Wilmanns, Matthias, Steingrimsson, E   +9 more
openaire   +4 more sources