Decoding the brain’s ATG8 paralog code: LC3–GABARAP specialization at synapses and the astrocyte–neuron interface [PDF]
Frontiers in Cell and Developmental BiologyMacroautophagy is essential for the long-term health of neurons and astrocytes in the central nervous system (CNS). The six mammalian ATG8 paralogs (LC3A/B/C and GABARAP/GABARAPL1/L2) exhibit an emerging “ATG8 code”—a division of labor among these ...
Haneul Choi, Seung-Min Lee, Jin-A. Lee
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Development of GABARAP family protein-sensitive LIR-based probes for neuronal autophagy
Molecular Brain, 2019 Autophagy allows for lysosomal cellular degradation of cytosolic components. In particular, neuronal autophagy is essential for cellular homeostasis and neuronal survival and is tightly regulated by several autophagy-related (ATG) proteins in post ...
Pureum Jeon +5 more
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Assessment of GABARAP self-association by its diffusion properties
Journal of Biomolecular NMR, 2010 Gamma-aminobutyric acid type A receptor-associated protein (GABARAP) belongs to a family of small ubiquitin-like adaptor proteins implicated in intracellular vesicle trafficking and autophagy. We have used diffusion-ordered nuclear magnetic resonance spectroscopy to study the temperature and concentration dependence of the diffusion properties of ...
Victor, Pacheco +6 more
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Integrated multi-omics reveals GABARAP-mediated mitophagy and pyruvate metabolism as key drivers of osteosarcoma progression [PDF]
Frontiers in ImmunologyBackgroundOsteosarcoma is a highly aggressive bone malignancy characterized by frequent metastasis and therapy resistance. Although mitophagy and pyruvate metabolism are increasingly recognized as critical metabolic regulators, their interaction in ...
Xiuxin Han +18 more
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LC3/GABARAP family proteins: autophagy‐(un)related functions
The FASEB Journal, 2016 ABSTRACT From yeast to mammals, autophagy is an important mechanism for sustaining cellular homeostasis through facilitating the degradation and recycling of aged and cytotoxic components. During autophagy, cargo is captured in double‐membraned vesicles, the autophagosomes, and degraded through lysosomal fusion ...
Schaaf, Marco B. E. +3 more
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Inhibition of GABARAP or GABARAPL1 prevents aminoglycoside- induced hearing loss [PDF]
Proceedings of the National Academy of SciencesAminoglycosides (AGs) are highly potent, broad-spectrum antibiotics frequently used as first-line treatments for multiple life-threatening infections. Despite their severe ototoxicity, causing irreversible hearing loss in millions of people annually, no preventive therapy has been approved.
Jinan Li +3 more
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Doxorubicin-induced glomerulosclerosis with proteinuria in GFP-GABARAP transgenic mice
American Journal of Physiology-Renal Physiology, 2012 Autophagy is a process of cellular degradation, and its dysfunction elicits many pathological symptoms. However, the contribution of autophagy to kidney glomerular function has not been fully clarified. We previously reported that LC3, a promising executor of autophagy, played an important role in recovery from podocyte damage in an experimental ...
Miyuki, Takagi-Akiba +9 more
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Integrating bioinformatics analysis, machine learning, and experimental validation to identify pyroptosis-related genes in the diagnosis of sepsis combined with acute liver failure [PDF]
HereditasBackground Sepsis is frequently combined with acute liver failure (ALF), a critical determinant in the mortality of septic patients. Pyroptosis is a significant form of programmed cell death that plays an important role in the inflammatory response ...
Jing Yan +7 more
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p62/SQSTM1 droplets initiate autophagosome biogenesis and oxidative stress control
Molecular & Cellular Oncology, 2021 Selective autophagy contributes to the degradation of condensates, such as sequestosome 1-bodies, also called p62/SQSTM1-bodies. We showed that endogenous p62 forms gel-like structures, which serve as platforms for autophagosome formation and nuclear ...
Eeva-Liisa Eskelinen +2 more
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MiR-761 promotes aortic valve calcification by inhibiting GABARAP expression
陆军军医大学学报, 2023 Objective To investigate the effect and potential mechanism of miR-761 on calcified aortic valve disease (CAVD). Methods Normal (n=6) and calcified (n=8) valve tissues were collected from Department of Cardiothoracic Surgery of the First Affiliated ...
XIANG Yi +3 more
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