Results 11 to 20 of about 10,328 (211)

The GABARAP Co-Secretome Identified by APEX2-GABARAP Proximity Labelling of Extracellular Vesicles [PDF]

Cells, 2020
The autophagy-related ATG8 protein GABARAP has not only been shown to be involved in the cellular self-degradation process called autophagy but also fulfils functions in intracellular trafficking processes such as receptor transport to the plasma ...
Julia L. Sanwald, Gereon Poschmann, Kai Stühler, Christian Behrends, Silke Hoffmann, Dieter Willbold   +5 more
doaj   +5 more sources

The crystal structure of the FAM134B–GABARAP complex provides mechanistic insights into the selective binding of FAM134 to the GABARAP subfamily [PDF]

FEBS Open Bio, 2022
The mammalian Atg8 family (Atg8s proteins) consists of two subfamilies: GABARAP and LC3. All members can bind to the LC3‐interacting region (LIR) or Atg8‐interacting motif and participate in multiple steps of autophagy.
Junfeng Zhao, Zhiwei Li, Jianchao Li
doaj   +3 more sources

Structural and Functional analysis of the GABARAP interaction motif (GIM) [PDF]

EMBO reports, 2016
© 2017 The Authors. Published under the terms of the CC BY 4.0 license. Through the canonical LC3 interaction motif (LIR), [W/F/Y]-X 1 -X 2 -[I/L/V], protein complexes are recruited to autophagosomes to perform their functions as either autophagy ...
Alexander Law, Alexandra Stolz, Andreas Kniss, Arvind C. Ravicahandran, David G. McEwan, Diana O. Rios-Szwed, Frank Löhr, Hironori Suzuki, Ivan Dikic, Renwick C.J. Dobson, Soichi Wakatsuki, Vladimir V. Rogov, Volker Dötsch   +12 more
core   +11 more sources

Critical assessment of LC3/GABARAP ligands used for degrader development and ligandability of LC3/GABARAP binding pockets [PDF]

Nature Communications
Recent successes in developing small molecule degraders that act through the ubiquitin system have spurred efforts to extend this technology to other mechanisms, including the autophagosomal-lysosomal pathway.
Martin P. Schwalm, Johannes Dopfer, Adarsh Kumar, Francesco A. Greco, Nicolas Bauer, Frank Löhr, Jan Heering, Sara Cano-Franco, Severin Lechner, Thomas Hanke, Ivana Jaser, Viktoria Morasch, Christopher Lenz, Daren Fearon, Peter G. Marples, Charles W. E. Tomlinson, Lorene Brunello, Krishna Saxena, Nathan B. P. Adams, Frank von Delft, Susanne Müller, Alexandra Stolz, Ewgenij Proschak, Bernhard Kuster, Stefan Knapp, Vladimir V. Rogov   +25 more
doaj   +4 more sources

Ceramide and the membrane-fusion activity of LC3/GABARAP autophagy proteins [PDF]

Cellular and Molecular Life Sciences
Macroautophagy is a cellular degradation process characterized by the formation of the double-membrane structure termed autophagosome (AP). The process of AP formation is not fully understood, but it is thought to happen through the combined action of ...
Yaiza R. Varela, Camila C. Aguirre, Marina N. Iriondo, Uxue Ballesteros, M. Isabel Collado, Asier Etxaniz, L. Ruth Montes, Felix M. Goñi, Alicia Alonso   +8 more
doaj   +2 more sources

NCOA4 initiates ferritinophagy by avidly binding GATE16 using two short linear interaction motifs [PDF]

Life Science Alliance
This study shows that NCOA4 engages GATE16 through two short linear motifs that bind avidly to support ferritinophagy, revealing how multivalent LC3/GABARAP interactions confer specificity and suggesting that iron directly regulates NCOA4•GATE16 binding ...
April Lee, Joseph H Davis
doaj   +2 more sources

Mechanisms and roles of membrane-anchored ATG8s [PDF]

Frontiers in Cell and Developmental Biology
Autophagy-related protein 8 (ATG8) family proteins, including LC3 and GABARAP subfamilies, are pivotal in canonical autophagy, driving autophagosome formation, cargo selection, and lysosomal fusion.
Soo-Kyeong Lee, Sang-Won Park, Deok-Jin Jang, Jin-A. Lee   +3 more
doaj   +2 more sources

GABARAP and GABAA Receptor Clustering [PDF]

Neuron, 2002
Coyle et al. (2002), in this issue of Neuron, reveal the crystal structure for the GABA(A) receptor binding protein, GABARAP. They show GABARAP can switch from a monomer to an extended linear polymer form that may function to assemble microtubules during the intracellular trafficking or postsynaptic clustering of GABA(A) receptors.
Phillips, William D., Froehner, Stanley C.   +1 more
openaire   +2 more sources

GABARAPs regulate PI4P-dependent autophagosome:lysosome fusion [PDF]

Proceedings of the National Academy of Sciences, 2015
Significance Autophagy is an essential homeostatic process that is critically important for maintaining health and that is dysregulated in multiple devastating diseases. The steps in the final stages of autophagy that culminate in autophagosome:lysosome fusion are not well understood.
Hanzhi, Wang, Hui-Qiao, Sun, Xiaohui, Zhu, Li, Zhang, Joseph, Albanesi, Beth, Levine, Helen, Yin   +6 more
openaire   +2 more sources

MiR-761 promotes aortic valve calcification by inhibiting GABARAP expression

陆军军医大学学报, 2023
Objective To investigate the effect and potential mechanism of miR-761 on calcified aortic valve disease (CAVD). Methods Normal (n=6) and calcified (n=8) valve tissues were collected from Department of Cardiothoracic Surgery of the First Affiliated ...
XIANG Yi, LI Xiaorong, LUO Jiangqiao, HE Wenhuan   +3 more
doaj   +1 more source