Results 21 to 30 of about 11,750 (172)

The crystal structure of mouse LC3B in complex with the FYCO1 LIR reveals the importance of the flanking region of the LIR motif. [PDF]

Acta Crystallogr F Struct Biol Commun, 2017
FYVE and coiled-coil domain-containing protein 1 (FYCO1), a multidomain autophagy adaptor protein, mediates microtubule plus-end-directed autophagosome transport by interacting with kinesin motor proteins and with the autophagosomal membrane components microtubule-associated protein 1 light chain 3 (LC3), Rab7 and phosphatidylinositol 3-phosphate (PI3P)
Sakurai S, Tomita T, Shimizu T, Ohto U.
europepmc   +4 more sources

ANKZF1 helps to eliminate stress-damaged mitochondria by LC3-mediated mitophagy [PDF]

Cell Death Discovery
Mitochondria, the double membrane-bound organelles of endosymbiotic origin, are crucial centers for cellular energy production and several essential metabolic pathways.
Mudassar Ali, Anjali, Koyeli Mapa
doaj   +2 more sources

AlphaFold2-multimer guided high-accuracy prediction of typical and atypical ATG8-binding motifs

PLoS Biology, 2023
Macroautophagy/autophagy is an intracellular degradation process central to cellular homeostasis and defense against pathogens in eukaryotic cells. Regulation of autophagy relies on hierarchical binding of autophagy cargo receptors and adaptors to ATG8 ...
Tarhan Ibrahim, Virendrasinh Khandare, Federico Gabriel Mirkin, Yasin Tumtas, Doryen Bubeck, Tolga O. Bozkurt   +5 more
doaj   +2 more sources

LIRcentral: a manually curated online database of experimentally validated functional LIR-motifs

Autophagy, 2022
AbstractSeveral selective macroautophagy receptor and adaptor proteins bind members of the Autophagy-related protein 8 (Atg8) family using short linear motifs (SLiMs), most often referred to as Atg8-interacting motifs (AIM) or LC3-interacting motifs (LIR).
Agathangelos Chatzichristofi, Vasileios Sagris, Aristos Pallaris, Marios Eftychiou, Ioanna Kalvari, Nicholas Price, Theodosios Theodosiou, Ioannis Iliopoulos, Ioannis P. Nezis, Vasilis J Promponas   +9 more
openaire   +4 more sources

Human ATG3 contains a non-canonical LIR motif crucial for its enzymatic activity in autophagy

, 2022
AbstractMacroautophagy is one of two major degradation systems in eukaryotic cells. Regulation and control of autophagy is often achieved through the presence of short peptide sequences called LC3 interacting regions (LIR) in autophagy-involved proteins.
Farnung J, Muhar M, Liang JR, Tolmachova KA, Benoit RM, Corn JE, Bode JW.   +6 more
europepmc   +2 more sources

Insights into links between autophagy and the ubiquitin system from the structure of LC3B bound to the LIR motif from the E3 ligase NEDD4. [PDF]

Protein Sci, 2017
AbstractMembers of the LC3/GABARAP family of ubiquitin‐like proteins function during autophagy by serving as membrane linked protein‐binding platforms. Their C‐termini are physically attached to membranes through covalent linkage to primary amines on lipids such as phosphatidylethanolamine, while their ubiquitin‐like fold domains bind “LIR” (LC3 ...
Qiu Y, Zheng Y, Wu KP, Schulman BA.
europepmc   +4 more sources

Label-free quantitative proteomic analysis of adult Drosophila heads

STAR Protocols, 2022
Summary: LIR motif-containing proteins (LIRCPs) bind to LDS (LIR motif docking site) of Atg8-family proteins. In this protocol, we describe steps to identify Drosophila LIRCPs, in Atg8a LDS mutants we have created, via label-free quantitative proteomic ...
Yan Zhang, Ioannis P. Nezis
doaj   +1 more source

The crystal structure of the FAM134B–GABARAP complex provides mechanistic insights into the selective binding of FAM134 to the GABARAP subfamily

FEBS Open Bio, 2022
The mammalian Atg8 family (Atg8s proteins) consists of two subfamilies: GABARAP and LC3. All members can bind to the LC3‐interacting region (LIR) or Atg8‐interacting motif and participate in multiple steps of autophagy.
Junfeng Zhao, Zhiwei Li, Jianchao Li
doaj   +1 more source

Biological properties of the BCL-2 family protein BCL-RAMBO, which regulates apoptosis, mitochondrial fragmentation, and mitophagy

Frontiers in Cell and Developmental Biology, 2022
Mitochondria play an essential role in the regulation of cellular stress responses, including cell death. Damaged mitochondria are removed by fission and fusion cycles and mitophagy, which counteract cell death.
Takao Kataoka, Takao Kataoka
doaj   +1 more source

Beyond Atg8 binding: The role of AIM/LIR motifs in autophagy [PDF]

Autophagy, 2017
Selective macroautophagy/autophagy mediates the selective delivery of cytoplasmic cargo material via autophagosomes into the lytic compartment for degradation. This selectivity is mediated by cargo receptor molecules that link the cargo to the phagophore (the precursor of the autophagosome) membrane via their simultaneous interaction with the cargo and
Dorotea Fracchiolla, Justyna Sawa-Makarska, Sascha Martens   +2 more
openaire   +3 more sources