Molecular determinants regulating selective binding of autophagy adapters and receptors to ATG8 proteins [PDF]
Nature Communications, 2019 Autophagy adaptors and receptors contain LC3-interacting region (LIR) motifs that bind selectively to the LIR docking site of GABARAP and other members of the ATG8 family. Here the authors show that in addition to the LIR motif also the region C-terminal
Martina Wirth +8 more
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Development of GABARAP family protein-sensitive LIR-based probes for neuronal autophagy
Molecular Brain, 2019 Autophagy allows for lysosomal cellular degradation of cytosolic components. In particular, neuronal autophagy is essential for cellular homeostasis and neuronal survival and is tightly regulated by several autophagy-related (ATG) proteins in post ...
Pureum Jeon +5 more
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LC3/GABARAPs drive ubiquitin-independent recruitment of Optineurin and NDP52 to amplify mitophagy [PDF]
Nature Communications, 2019 Selective autophagy receptors are thought to selectively recruit Atg8 positive membranes to cargo via their LIR motif. Here, the authors show the LIR motifs in OPTN and NDP52 are dispensable for selectivity, functioning instead to recruit additional ...
Benjamin Scott Padman +5 more
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Extracellular vesicle-based targeted protein degradation platform for multiple extracellular proteins [PDF]
EMBO Molecular MedicineTargeted protein degradation (TPD) is an emerging therapeutic approach that enables the degradation of undruggable targets via intracellular degradation systems.
Bide Tong +17 more
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TMEM259/MEMBRALIN is a non-canonical ER-phagy receptor that associates with MAN1B1 and VCP to eliminate viral glycoproteins [PDF]
Autophagy ReportsSelective autophagy of the endoplasmic reticulum (ER-phagy/reticulophagy) is essential for organelle homeostasis and host defense, yet how ER quality control (ERQC) pathways distinguish viral glycoproteins from misfolded host proteins remains poorly ...
Jim Maurice Camilleri +5 more
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ATG8 family proteins act as scaffolds for assembly of the ULK complex: sequence requirements for LC3-interacting region (LIR) motifs. [PDF]
The Journal of biological chemistry, 2012 Autophagy is a lysosome-dependent degradation system conserved among eukaryotes. The mammalian Atg1 homologues, Unc-51 like kinase (ULK) 1 and 2, are multifunctional proteins with roles in autophagy, neurite outgrowth, and vesicle transport. The mammalian ULK complex involved in autophagy consists of ULK1, ULK2, ATG13, FIP200, and ATG101.
Alemu, Endalkachew Ashenafi +9 more
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Coronavirus infectious bronchitis virus spike protein inhibits FUNDC1-mediated mitophagy to prevent nucleocapsid protein degradation [PDF]
Journal of VirologyAutophagy is involved in various stages of the viral life cycle and modulates viral replication. Coronaviruses have developed several strategies to exploit autophagy for their benefit.
Jun Zhao +9 more
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BLTP3A is associated with membranes of the late endocytic pathway and is an effector of CASM [PDF]
The EMBO JournalRecent studies have identified a family of rod-shaped proteins thought to mediate lipid transfer at intracellular membrane contacts by a bridge-like mechanism.
Michael G Hanna +8 more
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AlphaFold2-multimer guided high-accuracy prediction of typical and atypical ATG8-binding motifs
PLoS Biology, 2023 Macroautophagy/autophagy is an intracellular degradation process central to cellular homeostasis and defense against pathogens in eukaryotic cells. Regulation of autophagy relies on hierarchical binding of autophagy cargo receptors and adaptors to ATG8 ...
Tarhan Ibrahim +5 more
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ANKZF1 helps to eliminate stress-damaged mitochondria by LC3-mediated mitophagy [PDF]
Cell Death DiscoveryMitochondria, the double membrane-bound organelles of endosymbiotic origin, are crucial centers for cellular energy production and several essential metabolic pathways.
Mudassar Ali, Anjali, Koyeli Mapa
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