Results 21 to 30 of about 240,005 (160)

TMEM259/MEMBRALIN is a non-canonical ER-phagy receptor that associates with MAN1B1 and VCP to eliminate viral glycoproteins [PDF]

Autophagy Reports
Selective autophagy of the endoplasmic reticulum (ER-phagy/reticulophagy) is essential for organelle homeostasis and host defense, yet how ER quality control (ERQC) pathways distinguish viral glycoproteins from misfolded host proteins remains poorly ...
Jim Maurice Camilleri, Jing Zhang, Tao Wang, Iqbal Ahmad, Sunan Li, Yong-Hui Zheng   +5 more
doaj   +2 more sources

Coronavirus infectious bronchitis virus spike protein inhibits FUNDC1-mediated mitophagy to prevent nucleocapsid protein degradation [PDF]

Journal of Virology
Autophagy is involved in various stages of the viral life cycle and modulates viral replication. Coronaviruses have developed several strategies to exploit autophagy for their benefit.
Jun Zhao, Jiaxin Tian, Liwei Zhang, Yingfei Li, Lihua Tang, Qila Sa, Ruotong Li, Jing Zhao, Ye Zhao, Guozhong Zhang   +9 more
doaj   +2 more sources

Atg8 family proteins, LIR/AIM motifs and other interaction modes.

Atg8 family proteins, LIR/AIM motifs and other interaction modes.
The Atg8 family of ubiquitin-like proteins play pivotal roles in autophagy and other processes involving vesicle fusion and transport where the lysosome/vacuole is the end station. Nuclear roles of Atg8 proteins are also emerging.
Nobuo N Noda (17789678), Panagiotis Tsapras (17789675), Ioannis P Nezis (17789672), Christian Behrends (673832), Martina Wirth (3832903), Sharon A Tooze (8114291), Vladimir V Rogov (17789669), Hong Zhang (25820), Vojo Deretic (82884), Zvulun Elazar (3713575), Hitoshi Nakatogawa (676830), David G McEwan (17789681), Yasin Dagdas (5317883), Stephane Mouilleron (5166308), Ivan Dikic (24996), Trond Lamark (175604), Terje Johansen (25018)   +16 more
core   +3 more sources

AlphaFold2-multimer guided high-accuracy prediction of typical and atypical ATG8-binding motifs

PLoS Biology, 2023
Macroautophagy/autophagy is an intracellular degradation process central to cellular homeostasis and defense against pathogens in eukaryotic cells. Regulation of autophagy relies on hierarchical binding of autophagy cargo receptors and adaptors to ATG8 ...
Tarhan Ibrahim, Virendrasinh Khandare, Federico Gabriel Mirkin, Yasin Tumtas, Doryen Bubeck, Tolga O. Bozkurt   +5 more
doaj   +2 more sources

Label-free quantitative proteomic analysis of adult Drosophila heads

STAR Protocols, 2022
Summary: LIR motif-containing proteins (LIRCPs) bind to LDS (LIR motif docking site) of Atg8-family proteins. In this protocol, we describe steps to identify Drosophila LIRCPs, in Atg8a LDS mutants we have created, via label-free quantitative proteomic ...
Yan Zhang, Ioannis P. Nezis
doaj   +1 more source

Insights into links between autophagy and the ubiquitin system from the structure of LC3B bound to the LIR motif from the E3 ligase NEDD4. [PDF]

Protein Sci, 2017
AbstractMembers of the LC3/GABARAP family of ubiquitin‐like proteins function during autophagy by serving as membrane linked protein‐binding platforms. Their C‐termini are physically attached to membranes through covalent linkage to primary amines on lipids such as phosphatidylethanolamine, while their ubiquitin‐like fold domains bind “LIR” (LC3 ...
Qiu Y, Zheng Y, Wu KP, Schulman BA.
europepmc   +4 more sources

The crystal structure of the FAM134B–GABARAP complex provides mechanistic insights into the selective binding of FAM134 to the GABARAP subfamily

FEBS Open Bio, 2022
The mammalian Atg8 family (Atg8s proteins) consists of two subfamilies: GABARAP and LC3. All members can bind to the LC3‐interacting region (LIR) or Atg8‐interacting motif and participate in multiple steps of autophagy.
Junfeng Zhao, Zhiwei Li, Jianchao Li
doaj   +1 more source

Biological properties of the BCL-2 family protein BCL-RAMBO, which regulates apoptosis, mitochondrial fragmentation, and mitophagy

Frontiers in Cell and Developmental Biology, 2022
Mitochondria play an essential role in the regulation of cellular stress responses, including cell death. Damaged mitochondria are removed by fission and fusion cycles and mitophagy, which counteract cell death.
Takao Kataoka, Takao Kataoka
doaj   +1 more source

Use of Peptide Arrays for Identification and Characterization of LIR Motifs [PDF]

, 2019
The mammalian ATG8 proteins (LC3A-C/GABARAP, GABARAPL1, and GABARAPL2) are small ubiquitin-like proteins critically involved in macroautophagy. Their processed C-termini are posttranslationally conjugated to a phosphatidylethanolamine moiety, enabling their insertion into the lipid bilayers of both the inner and outer membranes of the forming ...
Rasmussen, Mads Skytte, Birgisdottir, Åsa birna, Johansen, Terje   +2 more
openaire   +3 more sources

iLIR : a web resource for prediction of Atg8-family interacting proteins [PDF]

, 2014
Macroautophagy was initially considered to be a nonselective process for bulk breakdown of cytosolic material. However, recent evidence points toward a selective mode of autophagy mediated by the so-called selective autophagy receptors (SARs).
Nezis, I. P., Osgood, Richard, Mulakkal, Nitha Charles, Promponas, Vasilis J., Kalvari, Ioanna, Johansen, Terje, Tsompanis, Stelios   +6 more
core   +1 more source