Amino acid motifs for the identification of novel protein interactants [PDF]
Computational and Structural Biotechnology Journal, 2023 Biological systems consist of multiple components of different physical and chemical properties that require complex and dynamic regulatory loops to function efficiently.
Aloysius Wong +4 more
doaj +4 more sources
Immunogenic amino acid motifs and linear epitopes of COVID-19 mRNA vaccines. [PDF]
PLoS ONE, 2021 Reverse vaccinology is an evolving approach for improving vaccine effectiveness and minimizing adverse responses by limiting immunizations to critical epitopes. Towards this goal, we sought to identify immunogenic amino acid motifs and linear epitopes of
Adam V Wisnewski +13 more
doaj +2 more sources
The mining of toxin-like polypeptides from EST database by single residue distribution analysis [PDF]
BMC Genomics, 2011 Background Novel high throughput sequencing technologies require permanent development of bioinformatics data processing methods. Among them, rapid and reliable identification of encoded proteins plays a pivotal role.
Grishin Eugene, Kozlov Sergey
doaj +2 more sources
Discovery of Novel Functional Centers With Rationally Designed Amino Acid Motifs [PDF]
Computational and Structural Biotechnology Journal, 2018 Plants are constantly exposed to environmental stresses and in part due to their sessile nature, they have evolved signal perception and adaptive strategies that are distinct from those of other eukaryotes.
Aloysius Wong +3 more
doaj +2 more sources
Comparative analysis of P450 signature motifs EXXR and CXG in the large and diverse kingdom of fungi: identification of evolutionarily conserved amino acid patterns characteristic of P450 family. [PDF]
PLoS ONE, 2014 Cytochrome P450 monooxygenases (P450s) are heme-thiolate proteins distributed across the biological kingdoms. P450s are catalytically versatile and play key roles in organisms primary and secondary metabolism.
Khajamohiddin Syed +1 more
doaj +3 more sources
Interpretable and generative deep learning models explicate phase separating intrinsically disordered motifs [PDF]
Nature CommunicationsIntrinsically disordered regions (IDRs) in proteins drive phase separation (PS) to form biomolecular condensates, which organize cellular matter. While IDRs are recognized as critical drivers of PS, the systematic identification of sequence motifs ...
Hongzhining Yang +5 more
doaj +2 more sources
TriPepSVM: de novo prediction of RNA-binding proteins based on short amino acid motifs. [PDF]
Nucleic Acids Res, 2019 Bressin A +5 more
europepmc +2 more sources
Analysis of repetitive amino acid motifs reveals the essential features of spider dragline silk proteins. [PDF]
PLoS One, 2017 Malay AD, Arakawa K, Numata K.
europepmc +2 more sources
Frontiers in Immunology, 2023 Few neoepitopes detected in tumor biopsies are immunogenic. Tumor-specific T cell responses require both the presentation of an epitope that differs from wildtype and the presence of T cells with neoepitope-cognate receptors.
E. Jane Homan, Robert D. Bremel
doaj +1 more source
The Influence of Short Motifs on the Anticancer Activity of HB43 Peptide
Pharmaceutics, 2022 Despite the remarkable similarity in amino acid composition, many anticancer peptides (ACPs) display significant differences in terms of activity. This strongly suggests that particular relative dispositions of amino acids (motifs) play a role in the ...
Claudia Herrera-León +9 more
doaj +1 more source