Results 11 to 20 of about 405,820 (287)

Self-Organizing Map for Characterizing Heterogeneous Nucleotide and Amino Acid Sequence Motifs [PDF]

Computation, 2017
A self-organizing map (SOM) is an artificial neural network algorithm that can learn from the training data consisting of objects expressed as vectors and perform non-hierarchical clustering to represent input vectors into discretized clusters, with ...
Xuhua Xia
doaj   +2 more sources

Reinvestigating the Photoprotection Properties of a Mycosporine Amino Acid Motif [PDF]

Frontiers in Chemistry, 2020
With the growing concern regarding commercially available ultraviolet (UV) filters damaging the environment, there is an urgent need to discover new UV filters. A family of molecules called mycosporines and mycosporine-like amino acids (referred to as MAAs collectively) are synthesized by cyanobacteria, fungi and algae and act as the natural UV filters
Abigail L. Whittock, Abigail L. Whittock, Matthew A. P. Turner, Matthew A. P. Turner, Matthew A. P. Turner, Daniel J. L. Coxon, Daniel J. L. Coxon, Daniel J. L. Coxon, Jack M. Woolley, Michael D. Horbury, Vasilios G. Stavros   +10 more
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Unravelling the Photoprotection Properties of Mycosporine Amino Acid Motifs [PDF]

The Journal of Physical Chemistry Letters, 2018
Photoprotection from harmful ultraviolet (UV) radiation exposure is a key problem in modern society. Mycosporine-like amino acids found in fungi, cyanobacteria, macroalgae, phytoplankton, and animals are already presenting a promising form of natural photoprotection in sunscreen formulations.
Jack M. Woolley, Michael Staniforth, Michael D. Horbury, Gareth W. Richings, Martin Wills, Vasilios G. Stavros   +5 more
openaire   +3 more sources

Complementary α-arrestin-ubiquitin ligase complexes control nutrient transporter endocytosis in response to amino acids

eLife, 2020
How cells adjust nutrient transport across their membranes is incompletely understood. Previously, we have shown that S. cerevisiae broadly re-configures the nutrient transporters at the plasma membrane in response to amino acid availability, through ...
Vasyl Ivashov, Johannes Zimmer, Sinead Schwabl, Jennifer Kahlhofer, Sabine Weys, Ronald Gstir, Thomas Jakschitz, Leopold Kremser, Günther K Bonn, Herbert Lindner, Lukas A Huber, Sebastien Leon, Oliver Schmidt, David Teis   +13 more
doaj   +1 more source

Genomic and proteomic biases inform metabolic engineering strategies for anaerobic fungi. [PDF]

, 2020
Anaerobic fungi (Neocallimastigomycota) are emerging non-model hosts for biotechnology due to their wealth of biomass-degrading enzymes, yet tools to engineer these fungi have not yet been established.
Albà, Arazoe, Atasoglu, Bach, Beckham, Bezanson, Birdsell, Boch, Bonugli-Santos, Brownlee, Calkins, Camacho, Camiolo, Carlson, Chan, Chen, Cheng, Cheng, Chokhawala, Coker, Deshpande, Diener, Dollhofer, Duarte, Durand, Duret, Fondon, Galtier, Gasiunas, Gentzsch, Gerngross, Glass, Glémin, Greene, Grigoriev, Haitjema, Haitjema, Hamilton, Hanafy, Hartfield, Henske, Hershberg, Hildebrand, Hull, Jiang, Karlin, Kiktev, Kleinstiver, Kleinstiver, Knauer, Knight, Kuyper, Leberer, Li, Liggenstoffer, Liu, Magee, Mertens, Meunier, Morrison, Murphy, Nicholson, Nieuwenhuis, Nørholm, Orpin, Oyola, O’Malley, Podolsky, Raymond, Reichenberger, Ropars, Sadhu, Sammond, Sekowska, Seppälä, Seppälä, Solieri, Solomon, Sonan, Staben, Steensels, Steensels, Sukumaran, Theodorou, UniProt: a worldwide hub of protein knowledge, Videvall, Wang, Wang, Wright, Wu, Ximenes, Youssef, Zetsche   +92 more
core   +1 more source

Stereoretentive cross-coupling of chiral amino acid chlorides and hydrocarbons through mechanistically controlled Ni/Ir photoredox catalysis

Nature Communications, 2022
Chiral α-amino ketones are privileged motifs in bioorganic and medicinal chemistry. Here, the authors develop an efficient method to synthesize these structures via stereoretentive direct cross-coupling of amino acid chlorides with simple aliphatic ...
Geun Seok Lee, Beomsoon Park, Soon Hyeok Hong   +2 more
doaj   +1 more source

Fluorine containing amino acids: synthesis and peptide coupling of amino acids containing the all-cis tetrafluorocyclohexyl motif [PDF]

Organic & Biomolecular Chemistry, 2015
A synthesis of amino acids carrying the all-cis tetrafluorocyclohexyl ring moiety is demonstrated and protection/deprotection elaborations are illustrated which show that this facially polarised ring motif may be incorporated into peptides.
Ayoup , Mohammed Salah, Cordes, David Bradford, Slawin, Alexandra Martha Zoya, O'Hagan, David   +3 more
openaire   +4 more sources

Word decoding of protein amino Acid sequences with availability analysis: a linguistic approach.

PLoS ONE, 2012
The amino acid sequences of proteins determine their three-dimensional structures and functions. However, how sequence information is related to structures and functions is still enigmatic.
Kenta Motomura, Tomohiro Fujita, Motosuke Tsutsumi, Satsuki Kikuzato, Morikazu Nakamura, Joji M Otaki   +5 more
doaj   +1 more source

Motivated Proteins: A web application for studying small three-dimensional protein motifs

BMC Bioinformatics, 2009
Background Small loop-shaped motifs are common constituents of the three-dimensional structure of proteins. Typically they comprise between three and seven amino acid residues, and are defined by a combination of dihedral angles and hydrogen bonding ...
Milner-White E James, Leader David P
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Determination of a predictive cleavage motif for eluted major histocompatibility complex class II ligands [PDF]

, 2018
CD4+ T cells have a major role in regulating immune responses. They are activated by recognition of peptides mostly generated from exogenous antigens through the major histocompatibility complex (MHC) class II pathway.
Dhanda, Sandeep Kumar, Edwards, Lindy, Jurtz, Vanessa, Karosiene, Edita, Nielsen, Morten, Paul, Sinu, Peters, Bjoern, Sette, Alessandro   +7 more
core   +6 more sources