Results 11 to 20 of about 257,506 (253)
Self-Organizing Map for Characterizing Heterogeneous Nucleotide and Amino Acid Sequence Motifs [PDF]
Computation, 2017 A self-organizing map (SOM) is an artificial neural network algorithm that can learn from the training data consisting of objects expressed as vectors and perform non-hierarchical clustering to represent input vectors into discretized clusters, with ...
Xuhua Xia
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Reinvestigating the Photoprotection Properties of a Mycosporine Amino Acid Motif [PDF]
Frontiers in Chemistry, 2020 With the growing concern regarding commercially available ultraviolet (UV) filters damaging the environment, there is an urgent need to discover new UV filters. A family of molecules called mycosporines and mycosporine-like amino acids (referred to as MAAs collectively) are synthesized by cyanobacteria, fungi and algae and act as the natural UV filters
Abigail L. Whittock +10 more
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Unravelling the Photoprotection Properties of Mycosporine Amino Acid Motifs [PDF]
The Journal of Physical Chemistry Letters, 2018 Photoprotection from harmful ultraviolet (UV) radiation exposure is a key problem in modern society. Mycosporine-like amino acids found in fungi, cyanobacteria, macroalgae, phytoplankton, and animals are already presenting a promising form of natural photoprotection in sunscreen formulations.
Jack M. Woolley +5 more
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Fluorine containing amino acids: synthesis and peptide coupling of amino acids containing the all-cis tetrafluorocyclohexyl motif [PDF]
Organic & Biomolecular Chemistry, 2015 A synthesis of amino acids carrying the all-cis tetrafluorocyclohexyl ring moiety is demonstrated and protection/deprotection elaborations are illustrated which show that this facially polarised ring motif may be incorporated into peptides.
Ayoup , Mohammed Salah +3 more
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Nature Communications, 2022 Chiral α-amino ketones are privileged motifs in bioorganic and medicinal chemistry. Here, the authors develop an efficient method to synthesize these structures via stereoretentive direct cross-coupling of amino acid chlorides with simple aliphatic ...
Geun Seok Lee +2 more
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Word decoding of protein amino Acid sequences with availability analysis: a linguistic approach.
PLoS ONE, 2012 The amino acid sequences of proteins determine their three-dimensional structures and functions. However, how sequence information is related to structures and functions is still enigmatic.
Kenta Motomura +5 more
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Motivated Proteins: A web application for studying small three-dimensional protein motifs
BMC Bioinformatics, 2009 Background Small loop-shaped motifs are common constituents of the three-dimensional structure of proteins. Typically they comprise between three and seven amino acid residues, and are defined by a combination of dihedral angles and hydrogen bonding ...
Milner-White E James, Leader David P
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The mining of toxin-like polypeptides from EST database by single residue distribution analysis
BMC Genomics, 2011 Background Novel high throughput sequencing technologies require permanent development of bioinformatics data processing methods. Among them, rapid and reliable identification of encoded proteins plays a pivotal role.
Grishin Eugene, Kozlov Sergey
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Phenotypic screening of signaling motifs that efficiently induce cell proliferation
Scientific Reports, 2023 Since cell proliferation is one of the fundamental cell fates, artificial control of cell proliferation based on a receptor-engineering approach is increasingly important in therapeutic and industrial applications.
Kirato Umene +2 more
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PLoS ONE, 2007 BackgroundShort linear motifs (SLiMs) in proteins are functional microdomains of fundamental importance in many biological systems. SLiMs typically consist of a 3 to 10 amino acid stretch of the primary protein sequence, of which as few as two sites may ...
Richard J Edwards +3 more
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