Structure motivator: a tool for exploring small three-dimensional elements in proteins [PDF]
, 2012 <br>Background: Protein structures incorporate characteristic three-dimensional elements defined by some or all of hydrogen bonding, dihedral angles and amino acid sequence.
Leader, D.P., Milner-White, E.J.
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Prediction and classification for GPCR sequences based on ligand specific features [PDF]
, 2006 Functional identification of G-Protein Coupled Receptors (GPCRs) is one of the current focus areas of pharmaceutical research. Although thousands of GPCR sequences are known, many of them are orphan sequences (the activating ligand is unknown). Therefore,
F. Horn +8 more
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Phenotypic screening of signaling motifs that efficiently induce cell proliferation
Scientific Reports, 2023 Since cell proliferation is one of the fundamental cell fates, artificial control of cell proliferation based on a receptor-engineering approach is increasingly important in therapeutic and industrial applications.
Kirato Umene +2 more
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PLoS ONE, 2007 BackgroundShort linear motifs (SLiMs) in proteins are functional microdomains of fundamental importance in many biological systems. SLiMs typically consist of a 3 to 10 amino acid stretch of the primary protein sequence, of which as few as two sites may ...
Richard J Edwards +3 more
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Sequence-Specific Recognition of DNA by Proteins: Binding Motifs Discovered Using a Novel Statistical/Computational Analysis. [PDF]
PLoS ONE, 2016 Decades of intensive experimental studies of the recognition of DNA sequences by proteins have provided us with a view of a diverse and complicated world in which few to no features are shared between individual DNA-binding protein families.
David Jakubec +2 more
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A Haystack Heuristic for Autoimmune Disease Biomarker Discovery Using Next-Gen Immune Repertoire Sequencing Data. [PDF]
, 2017 Large-scale DNA sequencing of immunological repertoires offers an opportunity for the discovery of novel biomarkers for autoimmune disease. Available bioinformatics techniques however, are not adequately suited for elucidating possible biomarker ...
Apeltsin, Leonard +3 more
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2-Amino-5-chloropyridine–fumaric acid (1/2)
Acta Crystallographica Section E, 2010 The asymmetric unit of the title compound, C5H5ClN2·0.5C4H4O4, comprises a neutral 2-amino-5-chloropyridine molecule and one half of a fumaric acid molecule which lies on an inversion center.
Madhukar Hemamalini, Hoong-Kun Fun
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Phosphorylated claspin interacts with a phosphate-binding site in the kinase domain of Chk1 during ATR-mediated activation [PDF]
, 2003 Claspin is essential for the ATR-dependent activation of Chk1 in Xenopus egg extracts containing incompletely replicated or UV-damaged DNA. The activated form of Claspin contains two repeated phosphopeptide motifs that mediate its binding to Chk1.
Dunphy, William G. +3 more
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A repeating 11‐mer amino acid motif and plant desiccation [PDF]
The Plant Journal, 1993 SummaryAmong the proteins that accumulate as plant seeds desiccate are several protein families that are composed principally of a tandemly repeated 11‐mer amino acid motif. Proteins containing the same motif accumulate in the desiccating leaves of a desiccation‐tolerant plant species.This motif is characterized by apolar residues in positions 1, 2, 5 ...
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Bayesian models and algorithms for protein beta-sheet prediction [PDF]
, 2011 Prediction of the three-dimensional structure greatly benefits from the information related to secondary structure, solvent accessibility, and non-local contacts that stabilize a protein's structure.
Altunbasak, Yucel +5 more
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