Results 21 to 30 of about 257,506 (253)

Sequence-Specific Recognition of DNA by Proteins: Binding Motifs Discovered Using a Novel Statistical/Computational Analysis. [PDF]

PLoS ONE, 2016
Decades of intensive experimental studies of the recognition of DNA sequences by proteins have provided us with a view of a diverse and complicated world in which few to no features are shared between individual DNA-binding protein families.
David Jakubec, Roman A Laskowski, Jiri Vondrasek   +2 more
doaj   +1 more source

Characterization and immunolocalization of a Cryptosporidium protein containing repeated amino acid motifs [PDF]

Infection and Immunity, 1993
The oocyst wall is one of the components that permits cryptosporidia both to survive in the environment and to retain infectivity. With the aim of identifying Cryptosporidium proteins specifically expressed at the oocyst stage, we screened lambda gt11 genomic libraries of Cryptosporidium parvum with both an oocyst antiserum and a specific genetic probe.
RANUCCI L, MULLER HM, LA ROSA G, RECKMANN I, MORALES MA, SPANO F, POZIO E, CRISANTI, Andrea   +7 more
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A six-amino-acid motif is a major determinant in functional evolution of HOX1 proteins [PDF]

Genes & Development, 2020
Gene duplication and divergence is a major driver in the emergence of evolutionary novelties. How variations in amino acid sequences lead to loss of ancestral activity and functional diversification of proteins is poorly understood. We used cross-species functional analysis of Drosophila Labial and its mouse HOX1 orthologs (HOXA1, HOXB1, and HOXD1) as ...
Narendra Pratap Singh, Bony De Kumar, Ariel Paulson, Mark E. Parrish, Ying Zhang, Laurence Florens, Joan W. Conaway, Kausik Si, Robb Krumlauf   +8 more
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A repeating 11‐mer amino acid motif and plant desiccation [PDF]

The Plant Journal, 1993
SummaryAmong the proteins that accumulate as plant seeds desiccate are several protein families that are composed principally of a tandemly repeated 11‐mer amino acid motif. Proteins containing the same motif accumulate in the desiccating leaves of a desiccation‐tolerant plant species.This motif is characterized by apolar residues in positions 1, 2, 5 ...
openaire   +2 more sources

2-Amino-5-chloropyridine–fumaric acid (1/2)

Acta Crystallographica Section E, 2010
The asymmetric unit of the title compound, C5H5ClN2·0.5C4H4O4, comprises a neutral 2-amino-5-chloropyridine molecule and one half of a fumaric acid molecule which lies on an inversion center.
Madhukar Hemamalini, Hoong-Kun Fun
doaj   +1 more source

Enzymatic activity of poliovirus RNA polymerase mutants with single amino acid changes in the conserved YGDD amino acid motif [PDF]

Journal of Virology, 1991
RNA-dependent RNA polymerases contain a highly conserved region of amino acids with a core segment composed of the amino acids YGDD which have been hypothesized to be at or near the catalytic active site of the molecule. Six mutations in this conserved YGDD region of the poliovirus RNA-dependent RNA polymerase were made by using oligonucleotide site ...
S A, Jablonski, M, Luo, C D, Morrow
openaire   +2 more sources

Analysis of amino acid motif of penicillin-binding proteins 1a, 2b, and 2x in invasive Streptococcus pneumoniae nonsusceptible to penicillin isolated from pediatric patients in Casablanca, Morocco

BMC Research Notes, 2018
Objectives This study aimed to investigate the nature of the amino acid motifs found in PBPs of Streptococcus pneumoniae isolates in invasive diseases from pediatric patients at Casablanca, Morocco.
Idrissa Diawara, Kaotar Nayme, Khalid Katfy, Abouddihaj Barguigua, Mohamed Kettani-Halabi, Houria Belabbes, Mohammed Timinouni, Khalid Zerouali, Naima Elmdaghri   +8 more
doaj   +1 more source

Global Variability of V3 Loop Tetrapeptide Motif: a Concern for HIV-1 Neutralizing Antibodies-based Vaccine Design and Antiretroviral Therapy

Journal of Medical Microbiology and Infectious Diseases, 2021
Introduction: HIV-1 gp120 V3 GPGR motif has an essential role in viral invasion, cell fusion, and pathogenesis but presents a significant variability that can implicate neutralizing antibodies and antiretroviral drug resistance.
Luciano Rodrigo Lopes, Antonio Carlos da Silva Junior, Paulo Bandiera-Paiva, Jorge Casseb   +3 more
doaj   +1 more source

Identification of nuclear localization signal and nuclear export signal of VP1 from the chicken anemia virus and effects on VP2 shuttling in cells

Virology Journal, 2019
Background VP1 of the chicken anemia virus (CAV) is a structural protein that is required for virus encapsulation. VP1 proteins are present both in the nucleus and cytoplasm; however, the functional nuclear localization signal (NLS) and nuclear export ...
Jai-Hong Cheng, Guan-Hua Lai, Yi-Yang Lien, Fang-Chun Sun, Shan-Ling Hsu, Pei-Chin Chuang, Meng-Shiou Lee   +6 more
doaj   +1 more source

rMotifGen: random motif generator for DNA and protein sequences

BMC Bioinformatics, 2007
Background Detection of short, subtle conserved motif regions within a set of related DNA or amino acid sequences can lead to discoveries about important regulatory domains such as transcription factor and DNA binding sites as well as conserved protein ...
Hardin C Timothy, Rouchka Eric C
doaj   +1 more source