Results 71 to 80 of about 3,587 (132)
American Journal of Physiology-Cell PhysiologyHaving identified LC3-interacting region (LIR) motifs 1/2 of A20 binding inhibitor of NF-κB-1 (ABIN-1) as mitophagy regulators in vitro, this study generated CRISPR-engineered ABIN1-ΔLIR1/2 mice lacking both LIR motifs to elucidate its in vivo significance.
Lisa Sophie Huber +22 more
openaire +4 more sources
Investigations of the molecular determinants of maize streak virus replication
, 1999 Includes bibliographical references.Geminiviruses replicate via a rolling circle mechanism, which initiates at the origin of replication located within the long intergenic region (LIR).
Willment, Janet Anne
core
Requirement of the LIR motif for the critical role of NBR1 in heat tolerance.
, 2013 (A) Diagrams of wild-type and mutant NBR1 proteins. The conserved W and I residues in the LIR motif between the two UBA domains were changed to A residues in the NBR1W661A/I664A (mNBR1) mutant protein. (B) Five weeks-old Arabidopsis Col-0 wild type (WT),
Jing-Quan Yu (102564) +6 more
core +1 more source
Mechanisms and roles of membrane-anchored ATG8s
Frontiers in Cell and Developmental BiologyAutophagy-related protein 8 (ATG8) family proteins, including LC3 and GABARAP subfamilies, are pivotal in canonical autophagy, driving autophagosome formation, cargo selection, and lysosomal fusion.
Soo-Kyeong Lee +3 more
doaj +1 more source
Frontiers in Bioengineering and Biotechnology, 2019 Autophagy is a degradative pathway associated with many pathological and physiological processes crucial for cell survival. During ER stress, while selective autophagy occurs via ER-phagy, the re-establishment of physiologic ER homeostasis upon ...
Ashalatha Sreshty Mamidi +3 more
doaj +1 more source
*Total energy of the complex formed between the LIR motif with the binding target LC3 family protein in kcal/mol. **Change in accessible surface area (angstroms squared) upon binding of the LIR motif to target LC3 protein.
Paul O’Maille (18196747) +14 more
core +1 more source
The Carboxyl-Terminal Amino Acids Render Pro-Human LC3B Migration Similar to Lipidated LC3B in SDS-PAGE [PDF]
, 2013 LC3 is widely used marker for macroautophagy assays. After translation pro-LC3 is processed by Atg4 to expose C-terminal glycine residue for downstream conjugation reactions to accomplish the conversion of LC3-I to LC3-II. SDS-PAGE based Western blot (Wb)
Wang, W +22 more
core +1 more source
Characterisation of bovine leukocyte Ig-like receptors
, 2012 Leukocyte Immunoglobulin-like receptors (LILR) are innate immune receptors involved in regulating both innate and adaptive immune functions. LILR show more interspecies conservation than the closely related Killer Ig-like receptors, and homologues have ...
Laing Ken +44 more
core +1 more source
Journal of Inflammation Research, 2022 Haifeng Zhang,* Houyi Sun,* Wei Zhang,* Yaozeng Xu, Dechun Geng Department of Orthopedics, the First Affiliated Hospital of Soochow University, Suzhou City, People’s Republic of China*These authors contributed equally to this workCorrespondence ...
Zhang H, Sun H, Zhang W, Xu Y, Geng D
doaj
RVFV LIR motifs interacts with LC3 family members in silico.
Representative structural models of LIR motif-containing peptides (orange) corresponding to NSs1-3 in complex with GABARAP (cyan) and LC3A (forest green) proteins, as calculated via AlphaFold and FoldX (Materials and Methods).
Paul O’Maille (18196747) +14 more
core +1 more source