Results 71 to 80 of about 240,005 (160)

Plant‐Based Production of Human Major Histocompatibility Complex Class II Molecules

Plant Biotechnology Journal, EarlyView.
ABSTRACT Major histocompatibility complex class II (MHC II) protein triggers adaptive immune responses by presenting antigens on antigen‐presenting cells (APCs) to be recognised by CD4+ T cells. Recombinant MHC II proteins are effective for the analysis of peptide‐binding interaction, detection of antigen‐specific T‐cells and clinical testing for donor‐
Abdelaziz Ramadan, Hiroko Miyadera, Kaho Oka, Kohei Ishikawa, Toshiya Kobayashi, Misaki Kobayashi, Mitsunori Shiroishi, Emiko Noguchi, Kenji Miura   +8 more
wiley   +1 more source

QuateXelero : an accelerated exact network motif detection algorithm [PDF]

, 2013
Finding motifs in biological, social, technological, and other types of networks has become a widespread method to gain more knowledge about these networks’ structure and function.
Dichter, Norbert, Norbert Dichter, Koch, Ina, Khakabimamaghani, Sahand, Iman Sharafuddin, Sharafuddin, Iman, Masoudi-Nejad, Ali, Ina Koch, Ali Masoudi-Nejad, Sahand Khakabimamaghani   +9 more
core   +2 more sources

LDHB suppresses the PDCoV proliferation by targeting viral nucleocapsid protein for autophagic degradation

Microbiology Spectrum
Porcine deltacoronavirus (PDCoV) is a newly identified enteric coronavirus that causes serious diarrhea and vomiting in pigs, leading to substantial economic losses globally.
Xiaohan Wu, Shijin Lan, Ying Wang, Shixing Yang, Quan Shen, Xiaochun Wang, Yuwei Liu, Hongfeng Yang, Likai Ji, Wen Zhang   +9 more
doaj   +1 more source

Autophagy Promotes Focal Adhesion Disassembly and Cell Motility of Metastatic Tumor Cells through the Direct Interaction of Paxillin with LC3

Cell Reports, 2016
Autophagy is a conserved catabolic process that plays a housekeeping role in eliminating protein aggregates and organelles and is activated during nutrient deprivation to generate metabolites and energy.
Marina N. Sharifi, Erin E. Mowers, Lauren E. Drake, Chris Collier, Hong Chen, Marta Zamora, Stephanie Mui, Kay F. Macleod   +7 more
doaj   +1 more source

A Century of Understanding and Harnessing Heterosis

Plant Breeding, EarlyView.
ABSTRACT Heterosis has shaped modern plant breeding since Darwin's 19th century observations that outcrossing restores vigour lost through selfing. While 100 years old, its mechanistic basis and deployability remain actively debated. Classical models of dominance, overdominance and epistasis provided the foundation for hybrid breeding and converted ...
Mohsen Mohammadi
wiley   +1 more source

Phase‐Sensitive Modeling Improves Fat DESPOT Multiparametric Relaxation Mapping in Fat‐Water Mixtures

Magnetic Resonance in Medicine, Volume 96, Issue 5, Page 2336-2349, November 2026.
ABSTRACT Purpose To improve on a multiparametric technique—known as Fat DESPOT—to map the fat‐ and water‐specific R1 (R1f, R1w), R2*, and proton density fat fraction (PDFF) by upgrading the parameter initialization and introducing explicit model sensitivity to the complex phase of the water and fat signals.
Renée‐Claude Bider, Cristian Ciobanu, Jorge Campos Pazmiño, Véronique Fortier, Evan McNabb, Ives R. Levesque   +5 more
wiley   +1 more source

replication-package-motif-action-study.zip

, 2023
 Replication package for motif action study. 
M A (13993116)
core   +1 more source

YIPF3 and YIPF4 regulate autophagic turnover of the Golgi apparatus

The EMBO Journal
The degradation of organelles by autophagy is essential for cellular homeostasis. The Golgi apparatus has recently been demonstrated to be degraded by autophagy, but little is known about how the Golgi is recognized by the forming autophagosome.
Shinri Kitta, Tatsuya Kaminishi, Momoko Higashi, Takayuki Shima, Kohei Nishino, Nobuhiro Nakamura, Hidetaka Kosako, Tamotsu Yoshimori, Akiko Kuma   +8 more
doaj   +1 more source

A Statistical Perspective on Transformers for Small Longitudinal Cohort Data

Statistics in Medicine, Volume 45, Issue 23-24, October 2026.
ABSTRACT Modeling of longitudinal cohort data typically involves complex temporal dependencies between multiple variables. There, the transformer architecture, which has been highly successful in language and vision applications, allows us to account for the fact that the most recently observed time points in an individual's history may not always be ...
Kiana Farhadyar, Maren Hackenberg, Kira Ahrens, Charlotte Schenk, Bianca Kollmann, Oliver Tüscher, Klaus Lieb, Michael M. Plichta, Andreas Reif, Raffael Kalisch, Martin Wolkewitz, Moritz Hess, Harald Binder   +12 more
wiley   +1 more source

Wnt signalosome assembly is governed by conformational flexibility of Axin and by the AP2 clathrin adaptor

Nature Communications
Wnt signal transduction relies on the direct inhibition of GSK3 by phosphorylated PPPSPxS motifs within the cytoplasmic tail of the LRP6 co-receptor. How GSK3 is recruited to LRP6 remains unclear.
Melissa V. Gammons, Elsa Franco-Echevarría, Tie-Mei Li, Trevor J. Rutherford, Miha Renko, Christopher Batters, Mariann Bienz   +6 more
doaj   +1 more source