Results 81 to 90 of about 3,587 (132)

RVFV NSs interacts with LC3A and GABARAP in silico via LIR motifs.

(A) The linear sequence of RVFV NSs (UniProt ID P21698) was annotated based on mobility and disorder analysis by MobiDB [73] and regions labeled as structured, disordered, and observed, where “observed” refers to experimentally observed residues in the ...
Paul O’Maille (18196747), Raphaël Cafaro (18196741), Normand Cyr (8897279), Kaylee Petraccione (18196726), Nicole Bracci (8259813), James Omichinski (6059414), Kylene Kehn-Hall (45085), Danuta Sastre (5074088), Ivan Akhrymuk (2934816), Lauren Panny (10481461), Andrew Silberfarb (18196744), Mohamed G. H. Ali (18196729), Haytham M. Wahba (18196732), Timothy Stocker (18196735), Maryna Akhrymuk (18196738)   +14 more
core   +1 more source

Duck STING mediates antiviral autophagy directing the interferon signaling pathway to inhibit duck plague virus infection

Veterinary Research
Migratory birds are important vectors for virus transmission, how migratory birds recognize viruses and viruses are sustained in birds is still enigmatic.
Bin Tian, Yanming Tian, Xuetong Wang, Dongjie Cai, Liping Wu, Mingshu Wang, Renyong Jia, Shun Chen, Dekang Zhu, Mafeng Liu, Qiao Yang, Ying Wu, Xinxin Zhao, Shaqiu Zhang, Di Sun, Juan Huang, Xumin Ou, Zhen Wu, Anchun Cheng   +18 more
doaj   +1 more source

Non-cytopathic bovine viral diarrhea virus (BVDV) inhibits innate immune responses via induction of mitophagy

Veterinary Research
Bovine viral diarrhea virus (BVDV) belongs to the genus Pestivirus within the family Flaviviridae. Mitophagy plays important roles in virus-host interactions.
Zhijun Li, Ying Zhang, Bao Zhao, Qinghong Xue, Chunjiang Wang, Siyu Wan, Jingyu Wang, Xiwen Chen, Xuefeng Qi   +8 more
doaj   +1 more source

Reticulophagy receptor FAM134C restrains BMP receptor signaling

The EMBO Journal
FAM134/RETREG family members are ER-phagy receptors that maintain cellular homeostasis by regulating endoplasmic reticulum turnover. However, possible non-ER-phagy functions of FAM134 proteins remain elusive.
Shuchen Gu, Hanchenxi Zhang, Jin Cao, Zhou He, Jianfeng Wu, Xia Liu, Mingjie Zheng, Ting Liu, Bin Zhao, Pinglong Xu, Qiming Sun, Jianping Jin, Xia Lin, Yi Yu, Jiahuai Han, Xin-Hua Feng   +15 more
doaj   +1 more source

ClustalO alignment of ATG3 protein sequences from Discoba (kinetoplastids and their relatives) surrounding the conserved, but atypical ATG8-binding LIR motif, as well as the ATG12-binding AIM12 motif only conserved outside of kinetoplastids.

The human protein is shown in the alignment to illustrate conservation. The AlphaFold2 multimer modelled structure of the complex is shown below. The atypical LIR motif is located on a loop that fits the surface of Leishmania infantum ATG8. (TIF)
Toby J. Gibson (17980281), Laszlo Dobson (17980284), Andras Zeke (17980278)   +2 more
core   +1 more source

Identification of a LIR motif in region 1 of DOR and TP53INP1 proteins.

, 2012
Panels A and B. DOR and TP53INP1a interact with all human LC3/GABARAP family members. Full-length DOR (A) and TP53INP1 (B), both fused to GFP, were in vitro translated in the presence of [35S]methionine, and tested in GST pull-down assays for interaction
Ana Sancho (175589), Javier U. Chicote (175618), Jordi Duran (36345), Rob DeSalle (175611), Antonio García-España (175594), Maria J. Macias (175609), Caroline Mauvezin (175600), David Sala (175615), Antonio Zorzano (35886), Miriam Royo (175613), Endalkachew A. Alemu (175602), Trond Lamark (175604), Terje Johansen (25018), Manuel Palacín (5649286)   +13 more
core   +1 more source

SUMO Interaction Motif Of Influenza A Virus Matrix Protein 2

, 2017
SUMOylation is a post-translational modification where SUMO a Small Ubiquitin-like Modifier is covalently bound to a lysine residue by a small set of known enzymes. SUMOylation regulates transcription, cell-cycle progression and DNA repair.
Jackson, Frederic St John Shore
core   +1 more source

Development of a New Autophagosome Sensor With an LC3-interacting Region (LIR) Motif and a Hydrophobic Domain [PDF]

Microscopy and Microanalysis, 2016
Yang Hoon Huh, Yu-Kyung Lee, Yong-Woo Jun, Su-Min Um, Bong-Kiun Kaang, Deok-Jin Jang, Jin-A Lee   +6 more
openaire   +1 more source

RVFV NSs interacts with LC3 family members in silico via LIR motifs.

Representative structural models of RVFV NSs (orange) in complex with GABARAPL1 and GABARAPL2 (cyan) and LC3B and LC3C (forest green) proteins, as calculated via AlphaFold and FoldX (Materials and Methods).
Paul O’Maille (18196747), Raphaël Cafaro (18196741), Normand Cyr (8897279), Kaylee Petraccione (18196726), Nicole Bracci (8259813), James Omichinski (6059414), Kylene Kehn-Hall (45085), Danuta Sastre (5074088), Ivan Akhrymuk (2934816), Lauren Panny (10481461), Andrew Silberfarb (18196744), Mohamed G. H. Ali (18196729), Haytham M. Wahba (18196732), Timothy Stocker (18196735), Maryna Akhrymuk (18196738)   +14 more
core   +1 more source

Autophagy and exosome dynamics in Radiation-Induced pulmonary fibrosis: the critical role of TRIB3

Respiratory Research
Objective Dysregulated autophagy plays a critical role in the pathogenesis of pulmonary fibrosis. The stress protein TRIB3 has been correlated with abnormal autophagy, but its specific contribution to radiation-induced pulmonary fibrosis (RIPF) remains ...
Na Li, Wenyue Zhao, Jiale Li, Dengfeng Zhang, Kejun Li, Mengmeng Yang, Xinran Lu, Liqing Du, Chang Xu, Qiang Liu   +9 more
doaj   +1 more source