Results 81 to 90 of about 240,005 (160)
Aging Cell, Volume 25, Issue 10, October 2026.Aging heart shows mitophagy flux congestion and mitochondrial dysfunction. Aberrant activation of the HIF‐3α‐BNIP3 axis induces mitophagy flux congestion in the aging heart. Mitochondrial transplantation rectifies the HIF‐3α‐BNIP3 axis and restores mitophagy flux by elevating ATP production in the aging heart.
Ning Jin +13 more
wiley +1 more source
eLife, 2017 Autophagy is a conserved cellular process involved in the elimination of proteins and organelles. It is also used to combat infection with pathogenic microbes.
Aimin Yang, Supansa Pantoom, Yao-Wen Wu
doaj +1 more source
Temporal Replication and Sampling Efficiency in High‐Frequency Autonomous and Manual eDNA Sampling
Environmental DNA, Volume 8, Issue 5, September‐October 2026.Accounting for temporal correlation in eDNA time series can improve the accuracy of ecological inference about the influence of hydrological covariates on eDNA concentration. Further, we found that MCE filters were more efficient than PES filters. ABSTRACT Environmental DNA (eDNA) sampling is a valuable tool for ecological research, but its reliability
Ben C. Augustine +6 more
wiley +1 more source
Plant, Cell &Environment, Volume 49, Issue 9, Page 6506-6520, September 2026.ABSTRACT Precise genome editing has transformed plant biology and crop improvement by enabling targeted modification of endogenous loci. Beyond gene knockout and base editing, the site‐specific insertion of exogenous DNA, particularly large DNA fragments, has become a central goal for engineering complex traits, reconstructing metabolic pathways and ...
Fengfeng Zhang +6 more
wiley +1 more source
The k-junction motif in RNA structure [PDF]
, 2014 The k-junction is a structural motif in RNA comprising a three-way helical junction based upon kink turn (k-turn) architecture. A computer program written to examine relative helical orientation identified the three-way junction of the Arabidopsis TPP ...
Daldrop, Peter +7 more
core +1 more source
eLife, 2016 Mitochondrial dysfunction underlies many prevalent diseases including heart disease arising from acute ischemia/reperfusion (I/R) injury. Here, we demonstrate that mitophagy, which selectively removes damaged or unwanted mitochondria, regulated ...
Weilin Zhang +14 more
doaj +1 more source
Structural and functional characterisation of a reconstructed ancestral strigolactone receptor
The Plant Journal, Volume 127, Issue 5, September 2026.Significance Statement Ancestral sequence reconstruction of the strigolactone receptor DWARF14 (D14) reveals that its substrate specificity and signalling mechanism have remained largely conserved in seed plants. Ancestral D14 exhibits improved recombinant yields, thermostability and catalytic activity relative to D14 from Arabidopsis thaliana ...
Andrew J. Tuckey +6 more
wiley +1 more source
Relations professionnelles entres bibliothèques et petits éditeurs indépendants (Les) [PDF]
L’enquête menée par le MOTif part d’un constat a priori simple : les petits éditeurs souhaitent être plus présents dans les rayons des bibliothèques, tandis que les bibliothécaires peuvent regretter de ne pas connaître ces mêmes éditeurs et par ...
Le MOTif
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BMB ReportsMammalian ATG8 proteins (mATG8s) are essential for selective autophagy because they recruit various proteins with LC3- interacting region (LIR) motifs to autophagic membranes. The RavZ protein, secreted by Legionella pneumophila, and mammalian ATG4B possess functional LIR motifs that participate in lipidated mATG8 deconjugation on autophagic membranes.
Sang-Won Park +8 more
openaire +2 more sources
American Journal of Physiology-Cell PhysiologyHaving identified LC3-interacting region (LIR) motifs 1/2 of A20 binding inhibitor of NF-κB-1 (ABIN-1) as mitophagy regulators in vitro, this study generated CRISPR-engineered ABIN1-ΔLIR1/2 mice lacking both LIR motifs to elucidate its in vivo significance.
Lisa Sophie Huber +22 more
openaire +4 more sources