Results 101 to 110 of about 11,750 (172)

TBK1 Induces the Formation of Optineurin Filaments That Condensate with Polyubiquitin and LC3 for Cargo Sequestration

Advanced Science, Volume 13, Issue 16, 18 March 2026.
Phosphorylation of Optineurin by TBK1 induces the formation of filaments that condensate upon binding to linear polyubiquitin. Membrane‐anchored LC3 partitions into these condensates, suggesting that phase separation of filamentous Optineurin with ubiquitylated cargo promotes the sequestration of cargo and its subsequent alignment with LC3‐positive ...
Maria G. Herrera, Lena Kühn, Lisa Jungbluth, Verian Bader, Laura J. Krause, David Kartte, Elias Adriaenssens, Sascha Martens, Jörg Tatzelt, Carsten Sachse, Konstanze F. Winklhofer   +10 more
wiley   +1 more source

Hypoxic mitophagy regulates mitochondrial quality and platelet activation and determines severity of I/R heart injury

eLife, 2016
Mitochondrial dysfunction underlies many prevalent diseases including heart disease arising from acute ischemia/reperfusion (I/R) injury. Here, we demonstrate that mitophagy, which selectively removes damaged or unwanted mitochondria, regulated ...
Weilin Zhang, He Ren, Chunling Xu, Chongzhuo Zhu, Hao Wu, Dong Liu, Jun Wang, Lei Liu, Wei Li, Qi Ma, Lei Du, Ming Zheng, Chuanmao Zhang, Junling Liu, Quan Chen   +14 more
doaj   +1 more source

A Non‐Mitophagy Activity of BNIP3L/NIX in Amygdala Glutamatergic Neurons is Essential for Contextual Fear Memory Formation

Advanced Science, Volume 13, Issue 18, 27 March 2026.
Contextual fear conditioning induces BNIP3L‐dependent mitochondrial fission in glutamatergic neurons of the BLA, independently of mitophagy. Loss of BNIP3L elevates Drp1Ser637 phosphorylation, thereby suppressing mitochondrial fission, compromising ATP production, and attenuating excitatory synaptic transmission.
Xingxian Zhang, Xinlei Mo, Xinyu Zhou, Xiaoliang Liu, Guizhi Li, Songhui Hu, Yangyang Lu, Chenze Zhu, Jinxi Feng, Zhitong Chen, Weiwei Hu, Yihui Cui, Zhong Chen, Xiangnan Zhang   +13 more
wiley   +1 more source

ATG8 family proteins act as scaffolds for assembly of the ULK complex: sequence requirements for LC3-interacting region (LIR) motifs.

The Journal of biological chemistry, 2012
Autophagy is a lysosome-dependent degradation system conserved among eukaryotes. The mammalian Atg1 homologues, Unc-51 like kinase (ULK) 1 and 2, are multifunctional proteins with roles in autophagy, neurite outgrowth, and vesicle transport. The mammalian ULK complex involved in autophagy consists of ULK1, ULK2, ATG13, FIP200, and ATG101.
Alemu, Endalkachew Ashenafi, Lamark, Trond, Torgersen, Knut Martin, Birgisdottir, Åsa birna, Larsen, Kenneth Bowitz, Jain, Ashish, Olsvik, Hallvard Lauritz, Øvervatn, Aud Karin, Kirkin, Vladimir, Johansen, Terje   +9 more
openaire   +4 more sources

State College Times, February 4, 1932 [PDF]

, 1932
Volume 20, Issue 27https://scholarworks.sjsu.edu/spartan_daily_1932/1008/thumbnail ...
San Jose State University, School of Journalism and Mass Communications
core   +3 more sources

State College Times, November 10, 1931 [PDF]

, 1931
Volume 20, Issue 10https://scholarworks.sjsu.edu/spartandaily/12696/thumbnail ...
San Jose State University, School of Journalism and Mass Communications
core   +1 more source

Mammalian mitophagy – from in vitro molecules to in vivo models [PDF]

, 2017
The autophagic turnover of mitochondria, termed mitophagy, is thought to play an essential role in not only maintaining the health of the mitochondrial network, but also that of the cell and organism as a whole. We have come a long way in identifying the
Ganley, Ian G., McWilliams, Thomas G., Rodger, Catherine E.   +2 more
core   +2 more sources

Mechanisms and roles of membrane-anchored ATG8s

Frontiers in Cell and Developmental Biology
Autophagy-related protein 8 (ATG8) family proteins, including LC3 and GABARAP subfamilies, are pivotal in canonical autophagy, driving autophagosome formation, cargo selection, and lysosomal fusion.
Soo-Kyeong Lee, Sang-Won Park, Deok-Jin Jang, Jin-A. Lee   +3 more
doaj   +1 more source

Structural Analysis of PfSec62-Autophagy Interacting Motifs (AIM) and PfAtg8 Interactions for Its Implications in RecovER-phagy in Plasmodium falciparum

Frontiers in Bioengineering and Biotechnology, 2019
Autophagy is a degradative pathway associated with many pathological and physiological processes crucial for cell survival. During ER stress, while selective autophagy occurs via ER-phagy, the re-establishment of physiologic ER homeostasis upon ...
Ashalatha Sreshty Mamidi, Ashalatha Sreshty Mamidi, Ananya Ray, Namita Surolia   +3 more
doaj   +1 more source

State College Times, March 15, 1934 [PDF]

, 1934
Volume 22, Issue 92https://scholarworks.sjsu.edu/spartandaily/12983/thumbnail ...
San Jose State University, School of Journalism and Mass Communications
core   +3 more sources