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Drug repositioning identifies potential autophagy inhibitors for the LIR motif p62/SQSTM1 protein

Computational Biology and Chemistry
Autophagy is a critical cellular process for degrading damaged organelles and proteins under stressful conditions and has casually been shown to contribute to tumor survival and drug resistance. Sequestosome-1 (SQSTM1/p62) is an autophagy receptor that interacts with its binding partners via the LC3-interacting region (LIR).
Narjes Asghari, Marco Cordani, Zahra Nayeri   +2 more
exaly   +4 more sources

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Characterization of the Interaction of GABARAPL-1 with the LIR Motif of NBR1

Journal of Molecular Biology, 2011
Selective autophagy requires the specific segregation of targeted proteins into autophagosomes. The selectivity is mediated by autophagy receptors, such as p62 and NBR1, which can bind to autophagic effector proteins (Atg8 in yeast, MAP1LC3 protein family in mammals) anchored in the membrane of autophagosomes.
Vladimir V Rogov, Frank Lohr, Peter Güntert   +2 more
exaly   +3 more sources

BELIMBING PADA TEMBANG LIR-ILIR SEBAGAI SUMBER INSPIRASI PENCIPTAAN MOTIF PENDOK KRAWANGAN TEMPEL [PDF]

Sanggitarupa, 2022
Star fruit is a fruit that lives in a tropical climate, which has a unique shape that has five circles, like stars. The shape of the star fruit is often associated with several symbolic meanings such as leadership, education, religion, morals and others. One of the excerpts from the song Lir-Ilir mentions that star fruit, which is then interpreted as a
Hesti Pradina, Aji Wiyoko
openaire   +2 more sources

In Silico Assessment of LIR Motif-Containing Proteins Binding to ATG8-Family Proteins

Methods in Molecular Biology
Selective autophagic degradation of cellular components has been shown to be mediated by the interaction of LIR motif-containing proteins with ATG8-family proteins. Here, we present a detailed methodology for the in silico evaluation of potential binding between LIR motif-containing proteins and ATG8-family proteins.
Ioannis P Nezis
exaly   +3 more sources

Phosphorylation of the LIR Domain of SCOC Modulates ATG8 Binding Affinity and Specificity

Journal of Molecular Biology, 2021
Autophagy is a highly conserved degradative pathway, essential for cellular homeostasis and implicated in diseases including cancer and neurodegeneration.
Martina Wirth, Stéphane Mouilleron, Wenxin Zhang   +2 more
exaly   +3 more sources

The LIR motif – crucial for selective autophagy

Journal of Cell Science, 2013
Summary (Macro)autophagy is a fundamental degradation process for macromolecules and organelles of vital importance for cell and tissue homeostasis. Autophagy research has gained a strong momentum in recent years because of its relevance to cancer, neurodegenerative diseases, muscular dystrophy, lipid storage disorders, development ...
Åsa Birna, Birgisdottir, Trond, Lamark, Terje, Johansen   +2 more
openaire   +2 more sources

Structural basis for the phosphorylation of FUNDC1 LIR as a molecular switch of mitophagy

Autophagy, 2016
Mitophagy is a fundamental process that determines mitochondrial quality and homeostasis. Several mitophagy receptors, including the newly identified FUNDC1, mediate selective removal of damaged or superfluous mitochondria through their specific ...
Changqian Zhou, Pengfei Ding, Yushan Zhu   +2 more
exaly   +2 more sources

Discovering LC3-interacting region (LIR) motifs in hemorrhagic fever viruses: Implications for host autophagy and viral replication.

Doctor of ...
Petraccione, Kaylee Diana
openaire   +2 more sources

The MHC class I binding proteins LIR-1 and LIR-2 inhibit Fc receptor-mediated signaling in monocytes

European Journal of Immunology, 1998
David Cosman, Luis Borges, D Cosman
exaly