Results 31 to 40 of about 429 (86)

Colocalization Assay with Fluorescent-tagged ATG8 Using a Nicotiana benthamiana-based Transient System

Bio-Protocol, 2022
Autophagy is an evolutionarily conserved intracellular degradation process. During autophagy, a set of autophagy-related (ATG) proteins orchestrate the formation of double-bound membrane vesicles called autophagosomes to engulf cytoplasmic material and ...
Jinyan Mai, Dandan Shang, Faqiang Li, Na Luo   +3 more
doaj   +1 more source

Unfolding Plant Defence: Endoplasmic Reticulum Stress Signalling at the Plant‐Pathogen Interface

Plant Biotechnology Journal, EarlyView.
ABSTRACT The endoplasmic reticulum (ER) stress response, a conserved proteostasis network, has emerged as a central hub that reprograms plant immunity during pathogen attack. This review synthesises how plants harness ER‐stress signalling to mount multilayered defences and how pathogens have evolved counterstrategies to subvert these pathways.
Zhe Meng, Shuqin Zheng, Federica Brandizzi, Yiran Liu, Chunlei Li, Congcong Ai, Yujiao Wang, Jiadong Qi, Xiuguo Zhang   +8 more
wiley   +1 more source

Mechanisms and roles of membrane-anchored ATG8s

Frontiers in Cell and Developmental Biology
Autophagy-related protein 8 (ATG8) family proteins, including LC3 and GABARAP subfamilies, are pivotal in canonical autophagy, driving autophagosome formation, cargo selection, and lysosomal fusion.
Soo-Kyeong Lee, Sang-Won Park, Deok-Jin Jang, Jin-A. Lee   +3 more
doaj   +1 more source

Proximity-dependent biotinylation screening identifies NbHYPK as a novel interacting partner of ATG8 in plants

BMC Plant Biology, 2019
Background Autophagy is a conserved, highly-regulated catabolic process that plays important roles in growth, development and innate immunity in plants.
Mercy W. Macharia, Wilfred Y. Z. Tan, Prem P. Das, Naweed I. Naqvi, Sek-Man Wong   +4 more
doaj   +1 more source

Selective Autophagy Receptor CsNBR1 Confers Citrus Huanglongbing Resistance by Degrading ‘Candidatus Liberibacter Asiaticus’ Virulence Effectors

Molecular Plant Pathology, Volume 27, Issue 7, July 2026.
Overexpression of CsNBR1 confers HLB resistance in citrus by degrading CLas effector proteins, including SDE5115, SDE1, SDE19 and SDE5, via the autophagy pathway. ABSTRACT The selective autophagy receptor NEIGHBOUR OF BRCA1 (NBR1) is a key regulator of plant immunity, but its role against bacterial pathogens remains poorly understood.
Yaqian Shi, Xuejin Cui, Fang Fang, Zaiyu Yang, Yalin Mei, Shimian Ma, Changyong Zhou, Xuefeng Wang   +7 more
wiley   +1 more source

Canonical and non-canonical roles for ATG8 proteins in autophagy and beyond

Frontiers in Molecular Biosciences, 2022
During autophagy, the ATG8 family proteins have several well-characterized roles in facilitating early, mid, and late steps of autophagy, including autophagosome expansion, cargo recruitment and autophagosome-lysosome fusion.
Steven Edward Reid, Srinivasa Prasad Kolapalli, Thorbjørn M. Nielsen, Lisa B. Frankel, Lisa B. Frankel   +4 more
doaj   +1 more source

STING Modulating ER‐Phagy in the Prelimbic Cortex Neurons Contributed to Neuropathic Pain and Emotional Comorbidity

CNS Neuroscience &Therapeutics, Volume 32, Issue 6, June 2026.
SNL induced ER‐phagy impairment and ER stress increase in the PrL neuron via STING and the STING pathway. Our data indicated that enhancing ER‐phagy in PrL neurons might provide analgesic and antidepressant effects through STING and its pathways in SNL mice. ABSTRACT Background Our previous data suggested that autophagy is crucial for neuropathic pain.
Yongda Liu, Xu Yang, Shihui Kuai, Xi Chen, Zhibin Wang, Zhongsheng Yang, Xiaochuan Guo, Xin He, Ping Zhao   +8 more
wiley   +1 more source

The interplay between pathogens and Atg8 family proteins: thousand‐faced interactions

FEBS Open Bio, 2021
Autophagy is an intracellular degradation and recycling process that can also remove pathogenic intracellular bacteria and viruses from within cells (referred to as xenophagy) and activate the adaptive immune responses.
Dávid Tóth, Gábor V. Horváth, Gábor Juhász   +2 more
doaj   +1 more source

Pathways of Protein Secretion in Prokaryotes and Eukaryotes: Molecular Mechanisms, Biological Functions, and Therapeutic Opportunities

MedComm, Volume 7, Issue 6, June 2026.
This graphical abstract delineates noncanonical protein secretion systems across eukaryotes and prokaryotes. Eukaryotic UcPS covers four ER–Golgi bypass pathways, enabling rapid leaderless protein export via direct transmembrane translocation or vesicle‐mediated release.
Qiyuan Yang, Jingfei Shi, Linlin Xu, Guangrui Zhao, Yue Chen, Lin Cheng, Xiaokang Li, Zhigang Sun, Shuhong Huang   +8 more
wiley   +1 more source

The Dual Role of Autophagy in Cancer: Mechanisms and Therapeutic Strategies

MedComm – Oncology, Volume 5, Issue 2, June 2026.
Autophagy is a conserved cellular process degrading dysfunctional organelles and protein aggregates to maintain cell homeostasis, and it exhibits context‐dependent duality in cancer. Autophagy functions as a critical tumor‐suppressive mechanism by preventing DNA damage and mutation during tumor initiation.
Xiang‐Zheng Gao, Yuheng Qin, Haoyu Wan, Guang Lu, Han‐Ming Shen   +4 more
wiley   +1 more source