Results 31 to 40 of about 18,950 (216)

Atg8 family proteins, LIR/AIM motifs and other interaction modes

Autophagy Reports, 2023
The Atg8 family of ubiquitin-like proteins play pivotal roles in autophagy and other processes involving vesicle fusion and transport where the lysosome/vacuole is the end station. Nuclear roles of Atg8 proteins are also emerging.
Vladimir V. Rogov, Ioannis P. Nezis, Panagiotis Tsapras, Hong Zhang, Yasin Dagdas, Nobuo N. Noda, Hitoshi Nakatogawa, Martina Wirth, Stephane Mouilleron, David G. McEwan, Christian Behrends, Vojo Deretic, Zvulun Elazar, Sharon A. Tooze, Ivan Dikic, Trond Lamark, Terje Johansen   +16 more
doaj   +1 more source

Distinct roles in autophagy and importance in infectivity of the two ATG4 cysteine peptidases of leishmania major [PDF]

, 2012
Macroautophagy in Leishmania, which is important for the cellular remodeling required during differentiation, relies upon the hydrolytic activity of two ATG4 cysteine peptidases (ATG4.1 and ATG4.2).
Afonso, Azad, Besteiro, Betin, Betin, Bhattacharya, Boya, Cabrera, Dalle-Donne, Deretic, Dolai, Dolai, Garami, Geng, Goldman, Graef, Graham H. Coombs, Hosokawa, Jeremy C. Mottram, Kim, Kimura, Kimura, Kirisako, Kirisako, Krebiehl, Köchl, Lee, Lemasters, Li, Manjithaya, Mariño, Mariño, Mariño, Medina-Acosta, Misslitz, Mortensen, Mottram, Mörck, Mörck, Nair, Okamoto, Read, Roderick A.M. Williams, Sacks, Schapira, Scherz-Shouval, Scherz-Shouval, Scherz-Shouval, Scherz-Shouval, Tanida, Tanida, Williams, Williams, Williams, Williams, Wong, Xie, Yoshimoto, Youle   +58 more
core   +1 more source

Characterization of the autophagy marker protein Atg8 reveals atypical features of autophagy in Plasmodium falciparum. [PDF]

PLoS ONE, 2014
Conventional autophagy is a lysosome-dependent degradation process that has crucial homeostatic and regulatory functions in eukaryotic organisms. As malaria parasites must dispose a number of self and host cellular contents, we investigated if autophagy ...
Rahul Navale, Atul, Aparna Devi Allanki, Puran Singh Sijwali   +3 more
doaj   +1 more source

Autophagic flux is required for the synthesis of triacylglycerols and ribosomal protein turnover in Chlamydomonas [PDF]

, 2018
Autophagy is an intracellular catabolic process that allows cells to recycle unneeded or damaged material to maintain cellular homeostasis. This highly dynamic process is characterized by the formation of double-membrane vesicles called autophagosomes ...
Couso Liáñez, Inmaculada Concepción, Crespo González, José Luis, Kim, Hee-Sik, Martínez Force, Enrique, Pérez Pérez, María Esther   +4 more
core   +1 more source

Modulation of plant autophagy during pathogen attack [PDF]

, 2017
In plants, the highly conserved catabolic process of autophagy has long been known as a means of maintaining cellular homeostasis and coping with abiotic stress conditions. Accumulating evidence has linked autophagy to immunity against invading pathogens,
Bozkurt, Tolga O., Duggan, Cian, Leary, Alexandre Y, Pandey, Pooja, Salguero Linares, Jose, Sanguankiattichai, Nattapong, Savage, Zachary D, Segretin, Maria Eugenia, Tumtas, Yasin, Yow, Rui Jin   +9 more
core   +1 more source

Atg8‐family interacting motif crucial for selective autophagy [PDF]

FEBS Letters, 2010
Autophagy is a bulk degradation system conserved among most eukaryotes. Recently, autophagy has been shown to mediate selective degradation of various targets such as aggregated proteins and damaged or superfluous organelles. Structural studies have uncovered the conserved specific interactions between autophagic receptors and Atg8‐family proteins ...
Nobuo N. Noda, Yoshinori Ohsumi, Fuyuhiko Inagaki   +2 more
openaire   +2 more sources

Tracking autophagy during proliferation and differentiation of trypanosoma brucei [PDF]

, 2014
Autophagy is a lysosome-dependent degradation mechanism that sequesters target cargo into autophagosomal vesicles. The Trypanosoma brucei genome contains apparent orthologues of several autophagy-related proteins including an ATG8 family. These ubiquitin-
Coombs, Graham H., Jones, Nathaniel G., Mottram, Jeremy C., Proto, William R.   +3 more
core   +3 more sources

Noncanonical ATG8–ABS3 interaction controls senescence in plants [PDF]

Nature Plants, 2019
Protein homeostasis is essential for cellular functions and longevity, and the loss of proteostasis is one of the hallmarks of senescence. Autophagy is an evolutionarily conserved cellular degradation pathway that is critical for the maintenance of proteostasis. Paradoxically, autophagy deficiency leads to accelerated protein loss by unknown mechanisms.
Min Jia, Xiayan Liu, Hui Xue, Yue Wu, Lin Shi, Rui Wang, Yu Chen, Ni Xu, Jun Zhao, Jingxia Shao, Yafei Qi, Lijun An, Jen Sheen, Fei Yu   +13 more
openaire   +2 more sources

Lipidation-independent vacuolar functions of Atg8 rely on its noncanonical interaction with a vacuole membrane protein

eLife, 2018
The ubiquitin-like protein Atg8, in its lipidated form, plays central roles in autophagy. Yet, remarkably, Atg8 also carries out lipidation-independent functions in non-autophagic processes. How Atg8 performs its moonlighting roles is unclear.
Xiao-Man Liu, Akinori Yamasaki, Xiao-Min Du, Valerie C Coffman, Yoshinori Ohsumi, Hitoshi Nakatogawa, Jian-Qiu Wu, Nobuo N Noda, Li-Lin Du   +8 more
doaj   +1 more source

AlphaFold2-multimer guided high-accuracy prediction of typical and atypical ATG8-binding motifs

PLoS Biology, 2023
Macroautophagy/autophagy is an intracellular degradation process central to cellular homeostasis and defense against pathogens in eukaryotic cells. Regulation of autophagy relies on hierarchical binding of autophagy cargo receptors and adaptors to ATG8 ...
Tarhan Ibrahim, Virendrasinh Khandare, Federico Gabriel Mirkin, Yasin Tumtas, Doryen Bubeck, Tolga O. Bozkurt   +5 more
doaj   +2 more sources