Results 21 to 30 of about 11,891 (170)
New thoughts regarding Atg8 and ubiquitination [PDF]
Autophagy, 2011 Until recently, a clear functional division between the ubiquitin-proteasome system and macroautophagy was common sense. It was thought that ubiquitination targets short-lived or damaged proteins for degradation to the proteasome, whereas macroautophagy nonselectively removes parts of the cytoplasm.
Thumm, Michael, Klionsky, Daniel J.
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Conserved Atg8 recognition sites mediate Atg4 association with autophagosomal membranes and Atg8 deconjugation [PDF]
The EMBO Reports, 2017 Deconjugation of the Atg8/LC3 protein family members from phosphatidylethanolamine (PE) by Atg4 proteases is essential for autophagy progression, but how this event is regulated remains to be understood. Here, we show that yeast Atg4 is recruited onto autophagosomal membranes by direct binding to Atg8 via two evolutionarily conserved Atg8 recognition ...
Susana Abreu +14 more
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Atg4 plays an important role in efficient expansion of autophagic isolation membranes by cleaving lipidated Atg8 in Saccharomyces cerevisiae. [PDF]
PLoS ONE, 2017 Autophagy, an intracellular degradation system, is highly conserved among eukaryotes from yeast to mammalian cells. In the yeast Saccharomyces cerevisiae, most Atg (autophagy-related) proteins, which are essential for autophagosome formation, are ...
Eri Hirata +2 more
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Autophagy Reports, 2023 There are two types of autophagy, non-selective (bulk) autophagy, in which substrates are randomly incorporated into autophagosomes, and selective autophagy, in which substrates are specifically targeted.
Takashi Kikuma, Joichiro Nishio
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Frontiers in Cellular and Infection Microbiology, 2022 Autophagy is one of the bulk degradation systems and is conserved throughout eukaryotes. In the enteric protozoan parasite Entamoeba histolytica, the causative agent of human amebiasis, Atg8 is not exclusively involved in autophagy per se but also in ...
Kumiko Nakada-Tsukui +5 more
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Plant Signaling & Behavior, 2023 Potato virus Y (PVY) is an aphid-transmitted potyvirus that affects economically important solanaceous species. In this study, the phenomena and mechanisms following infection with PVY were investigated in tobacco (Nicotiana benthamiana).
Won-Jin Kim +4 more
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Mammalian Atg8s: One is simply not enough [PDF]
Autophagy, 2010 Yeast Atg8, a key factor in the autophagic process, is a ubiquitin-like protein that undergoes a unique conjugation to phosphatidylethanolamine (PE). Atg8 plays a dual role in early stages of autophagosome formation: It was implicated in recruitment of cargo proteins such as Atg19 and Atg32 for Cvt and mitophagy, respectively, and in autophagosome ...
Hilla, Weidberg +3 more
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Atg8 family proteins, LIR/AIM motifs and other interaction modes
Autophagy Reports, 2023 The Atg8 family of ubiquitin-like proteins play pivotal roles in autophagy and other processes involving vesicle fusion and transport where the lysosome/vacuole is the end station. Nuclear roles of Atg8 proteins are also emerging.
Vladimir V. Rogov +16 more
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Distribution, cleavage and lipidation of Atg8 fusion proteins in Spodoptera litura Sl-HP cells.
PLoS ONE, 2014 Atg8 proteins fused with tags are commonly used to detect autophagy. The expression patterns of Lepidopteran insect Atg8 are relatively well documented. However, the influence of protein tags on characterization of Atg8 is still not very clear.
Xiaojuan Zhang +8 more
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Atg8 is Essential for Macropexophagy in Hansenula polymorpha [PDF]
Traffic, 2004 We have isolated a peroxisome‐degradation‐deficient (pdd) mutant of the methylotrophic yeast Hansenula polymorpha via gene tagging mutagenesis. Sequencing revealed that the mutant was affected in the HpATG8 gene. HpAtg8 is a protein with high sequence similarity to both Pichia pastoris and Saccharomyces cerevisiae Atg8 and appeared to be essential for
Monastyrska, I. +6 more
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