Results 181 to 190 of about 10,328 (211)
The autophagy component LC3 regulates lymphocyte adhesion via LFA1 transport in response to outside-in signaling. [PDF]
Nat CommunKondo N +4 more
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Centriolar Satellites Control GABARAP Ubiquitination and GABARAP-Mediated Autophagy [PDF]
Current Biology, 2017 Autophagy maintains cellular health and homeostasis during stress by delivering cytosolic material captured by autophagosomes to lysosomes for degradation. Autophagosome formation is complex: initiated by the recruitment of autophagy (Atg) proteins to the formation site, it is sustained by activation of Atg proteins to allow growth and closure of the ...
Justin Joachim +2 more
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A conserved ATG2‐GABARAP family interaction is critical for phagophore formation
EMBO Reports, 2020 The intracellular trafficking pathway, macroautophagy, is a recycling and disposal service that can be upregulated during periods of stress to maintain cellular homeostasis. An essential phase is the elongation and closure of the phagophore to seal and isolate unwanted cargo prior to lysosomal degradation.
Luuk van den Bekerom +2 more
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GABARAP: Lessons for Synaptogenesis
The Neuroscientist, 2003The clustering of neurotransmitter receptors at the postsynaptic terminals is a critical requirement for efficient neurotransmission and neuronal communication. This process is facilitated by adaptor proteins, which bridge the postsynaptic receptors and the underlying cytoskeleton. One such molecule, the GABAA receptor-associated protein, GABARAP, was
Joseph E, Coyle, Dimitar B, Nikolov
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LC3/GABARAP binding to fluid membranes is potentiated by ceramide
Autophagy, 2022LC3/GABARAP constitute a macroautophagy/autophagy-related protein family derived from yeast Atg8. The involvement of specific lipids in LC3/GABARAP function is poorly understood. Exploring the interaction of LC3/GABARAP proteins with phosphatidylcholine- or sphingomyelin-based bilayers has revealed that cardiolipin is essential for the protein-bilayer ...
Yaiza R Varela, Alicia Alonso
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Structural characterization of GABARAP–ligand interactions
Molecular BioSystems, 2009The GABA(A) receptor-associated protein (GABARAP) plays an important role in intracellular trafficking of several proteins. It undergoes a C-terminal lipidation process that enables anchoring in the cytosolic leaflet of cellular membranes. While the three-dimensional structure of GABARAP itself has been determined, structural investigation of complexes
Yvonne, Thielmann +3 more
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