Results 191 to 200 of about 10,328 (211)

Specific distribution of gabarap, gec1/gabarap Like 1, gate16/gabarap Like 2, lc3 messenger RNAs in rat brain areas by quantitative real-time PCR

Brain Research, 2006
GABARAP and GEC1/GABARAPL1 interact with tubulin and GABA(A) receptor and belong to a new protein family. This family includes GATE 16 and LC3, potentially involved in intracellular transport processes. In this study, we combined brain dissection and quantitative real-time reverse transcription polymerase chain reaction to study discriminatively ...
Mansuy-Schlick, Virginie, Tolle, Fabrice, Delage-Mourroux, Régis, Fraichard, Annick, Risold, P. Y., Jouvenot, Michèle   +5 more
openaire   +3 more sources

LC3/GABARAP family proteins: autophagy‐(un)related functions

The FASEB Journal, 2016
ABSTRACT From yeast to mammals, autophagy is an important mechanism for sustaining cellular homeostasis through facilitating the degradation and recycling of aged and cytotoxic components. During autophagy, cargo is captured in double‐membraned vesicles, the autophagosomes, and degraded through lysosomal fusion ...
Schaaf, Marco B. E., Keulers, Tom G., Vooijs, Marc A., Rouschop, Kasper M. A.   +3 more
openaire   +3 more sources

Doxorubicin-induced glomerulosclerosis with proteinuria in GFP-GABARAP transgenic mice

American Journal of Physiology-Renal Physiology, 2012
Autophagy is a process of cellular degradation, and its dysfunction elicits many pathological symptoms. However, the contribution of autophagy to kidney glomerular function has not been fully clarified. We previously reported that LC3, a promising executor of autophagy, played an important role in recovery from podocyte damage in an experimental ...
Miyuki, Takagi-Akiba, Katsuhiko, Asanuma, Isei, Tanida, Norihiro, Tada, Juan Alejandro, Oliva Trejo, Kanae, Nonaka, Etsuko, Asanuma, Eiki, Kominami, Takashi, Ueno, Yasuhiko, Tomino   +9 more
openaire   +2 more sources

PLEKHM1 Regulates Autophagosome-Lysosome Fusion through HOPS Complex and LC3/GABARAP Proteins [PDF]

Molecular Cell, 2015
The lysosome is the final destination for degradation of endocytic cargo, plasma membrane constituents, and intracellular components sequestered by macroautophagy. Fusion of endosomes and autophagosomes with the lysosome depends on the GTPase Rab7 and the homotypic fusion and protein sorting (HOPS) complex, but adaptor proteins that link endocytic and ...
David G Mcewan, Doris Popovic, Andrea Gubas   +2 more
exaly   +3 more sources

[Cloning and expression of human GABARAP and preparation of anti-GABARAP antibodies].

Sheng wu gong cheng xue bao = Chinese journal of biotechnology, 2009
GABARAP, a microtuble-associated protein, is identified to interact with GABAA receptor. Anchoring of the GABAA receptor to GABARAP helps to cluster the receptor at the synaptic termini and to mediate fast synaptic transmission. GABARAP may mediate interaction of gephyrin with the GABAA receptor to stabilize clusters by forming multimeric structures ...
Xueni, Li, Liang, Han, Fang, Wang, Sersur, Ng, Hui, Zhang, Zhijie, Chang   +5 more
openaire   +1 more source

Targeting LC3/GABARAP for degrader development and autophagy modulation

2023
AbstractRecent successes in developing small-molecule degraders that act through the ubiquitin system have spurred efforts to extend this technology to other mechanisms, including the autophagosomal-lysosomal pathway. Therefore, reports of autophagosome tethering compounds (ATTECs) have received considerable attention from the drug development ...
Martin P. Schwalm, Johannes Dopfer, Adarsh Kumar, Francesco A. Greco, Nicolas Bauer, Frank Löhr, Jan Heering, Sara Cano, Severin Lechner, Thomas Hanke, Ivana Bekic, Viktoria Morasch, Daren Fearon, Peter G. Marples, Charles W. E. Tomlinson, Lorene Brunello, Krishna Saxena, Nathan Adams, Frank von-Delft, Susanne Müller, Alexandra Stolz, Ewgenij Proschak, Bernhard Kuster, Stefan Knapp, Vladimir V. Rogov   +24 more
openaire   +1 more source

An atypical LIR motif within UBA5 (ubiquitin like modifier activating enzyme 5) interacts with GABARAP proteins and mediates membrane localization of UBA5

Autophagy, 2020
Jessica Huber, Masato Akutsu, Frank Loehr   +2 more
exaly  

Human LC3 and GABARAP subfamily members achieve functional specificity via specific structural modulations

Autophagy, 2020
Nidhi Jatana, David B Ascher, Douglas E V Pires   +2 more
exaly  

Structure-Based Design of Stapled Peptides That Bind GABARAP and Inhibit Autophagy

Journal of the American Chemical Society, 2022
Tiffany Tsang, Oliver H Weiergräber, Assoc prof Joshua A Kritzer   +2 more
exaly  

Members of the autophagy class III phosphatidylinositol 3-kinase complex I interact with GABARAP and GABARAPL1 via LIR motifs

Autophagy, 2019
Stéphane Mouilleron, Åsa Birna Birgisdottir, Martina Wirth   +2 more
exaly