Results 91 to 100 of about 339,221 (330)

Real-time visualization of HIV-1 GAG trafficking in infected macrophages.

open access: yesPLoS Pathogens, 2008
HIV-1 particle production is driven by the Gag precursor protein Pr55(Gag). Despite significant progress in defining both the viral and cellular determinants of HIV-1 assembly and release, the trafficking pathway used by Gag to reach its site of assembly
Karine Gousset   +7 more
doaj   +1 more source

Determinant of HIV-1 mutational escape from cytotoxic T lymphocytes. [PDF]

open access: yes, 2003
CD8+ class I-restricted cytotoxic T lymphocytes (CTLs) usually incompletely suppress HIV-1 in vivo, and while analogous partial suppression induces antiretroviral drug-resistance mutations, epitope escape mutations are inconsistently observed.
Ali, Ayub   +6 more
core  

Growth factors for clinical-scale expansion of human articular chondrocytes : Relevance for automated bioreactor systems [PDF]

open access: yes, 2007
The expansion of chondrocytes in automated bioreactors for clinical use requires that a relevant number of cells be generated, starting from variable initial seeding densities in one passage and using autologous serum.
Andrea Barbero   +12 more
core   +1 more source

Practical Guide to the Design of Granular Hydrogels for Customizing Complex Cellular Microenvironments

open access: yesAdvanced Healthcare Materials, EarlyView.
Granular hydrogels are emerging microporous platforms for cell culture and delivery, showing great potential for replicating the complex, heterogeneous environments found in natural tissues. This review outlines the design principles of granular hydrogels, highlighting critical factors that determine the final physicochemical properties of the entire ...
Shuhan Feng, Kaiyang Chen, Shiqi Wang
wiley   +1 more source

Suppressing t(4;11) Acute Leukemia by Lipopolymer Nanoparticle Delivery of siRNA Targeting KMT2A::AFF1 with Enhanced Extrahepatic Delivery

open access: yesAdvanced Healthcare Materials, EarlyView.
This study introduces a new lipopolymer nanoparticle (LPNP) system that efficiently delivers siRNA to leukemia cells. The LPNPs silence the leukemia fusion gene KMT2A::AFF1, induce apoptosis, and decrease leukemia burden in mice. These results demonstrate the potential of LPNPs as a targeted siRNA therapy for acute lymphoblastic leukemia.
Mohammad Nasrullah   +9 more
wiley   +1 more source

Fibres and Fabrics: Indian Labour Organisations Still Gagged (More Information on Demands) [PDF]

open access: yes, 2007
The article details the demands of the Clean Clothes Campaign and other organizations pertaining to the gag order preventing Indian labor organizations from communicating the injustices and labor violations occurring at the Fibres and Fabrics ...
Clean Clothes Campaign
core   +1 more source

Natriuretic peptide receptors regulate cytoprotective effects in a human ex vivo 3D/bioreactor model [PDF]

open access: yes, 2013
© 2013 Peake et al.; licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and ...
Achan, P   +8 more
core   +2 more sources

Bioassembly of Region‐Specific Fibrocartilage Microtissues to Engineer Zonally Defined Meniscal Grafts

open access: yesAdvanced Healthcare Materials, EarlyView.
Meniscal microtissues are fabricated using progenitor cells isolated from the inner (iMPCs) and outer (oMPCs) regions of the meniscus. Meniscal microtissues fuse into cohesive constructs rich in sGAG and collagen. cABC treatment modulates collagen fiber formation and organization in assembled grafts.
Gabriela S. Kronemberger   +4 more
wiley   +1 more source

The Gag Rule: From Compromise to Contradiction [PDF]

open access: yes, 2015
This essay examines the gag rule of 1836, its motivations and effects. Enacted in 1836 to counter the growing vitriol of the slavery debates, it was later repealed in 1844, following sustained controversy.
Byram, Timothy A
core   +1 more source

Conducting Polymer Coatings for Bioelectronic Arthroscopy Probes

open access: yesAdvanced Healthcare Materials, EarlyView.
Schematic of a poly(3,4‐ethylenedioxythiophene, PEDOT)‐coated arthroscopy probe, featuring a semi‐spherical probe with 38 microelectrodes, used to measure streaming potential generated during cartilage indentation in the knee. The inset includes a scanning electron microscopy (SEM) image of the porous PEDOT layer deposited on a nickel‐phosphorus coated
Sara Ebrahimi   +6 more
wiley   +1 more source

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