Results 81 to 90 of about 186,106 (305)

Gag Determinants of Fitness and Drug Susceptibility in Protease Inhibitor-Resistant Human Immunodeficiency Virus Type 1

, 1999
Mutations can accumulate in the protease and gag genes of human immunodeficiency virus in patients who fail therapy with protease inhibitor drugs. Mutations within protease, the drug target, have been extensively studied.
Pillay, D., Boinett, C.J., Towers, G.J., Parry, C.M., Kohli, A., McCormick, A.L., A. Kohli, C. J. Boinett, G. J. Towers, C. M. Parry, A. L. McCormick, D. Pillay   +11 more
core   +1 more source

Longitudinal Multifrequency MR Elastography Reveals Biomechanical Signatures of Progression in a Translational Liver Tumor Model

Advanced Science, EarlyView.
Longitudinal multifrequency magnetic resonance elastography (mMRE) performed on a clinical 3 Tesla magnetic resonance imaging system reveals early biomechanical alterations during liver tumor progression in a translational VX2 model. Changes in tumor stiffness and viscosity precede diffusion‐related alterations and are associated with extracellular ...
Justus Ramtke, Friederike Hesse, Lasse Noack, Justus Klockner, Yubei He, Yu Liu, Yanglei Wu, Robin Schmidt, Selma Saclier, Salma A. S. Abosabie, Tom Meyer, Richard Ruppel, Nikolaus Berndt, Michael Mülleder, Eyk Schellenberger, Nicola Beindorff, Dominik N. Müller, Ingolf Sack, Jing Guo, Shraga Nahum Goldberg, Lynn Jeanette Savic   +20 more
wiley   +1 more source

Evolution of HIV-1 subtype C immune responses during acute and chronic HIV infection [PDF]

, 2011
The aim of this study was to compare the magnitude and breadth of HIV-specific T cell responses to HIV Gag and Nef mounted during acute HIV infection with those that emerged during chronic infection and to investigate the association of these responses ...
Gamieldien, Hoyam
core   +1 more source

Molecular mechanisms by which HERV-K Gag interferes with HIV-1 Gag assembly and particle infectivity

Retrovirology, 2017
Background Human endogenous retroviruses (HERVs), the remnants of ancient retroviral infections, constitute approximately 8% of human genomic DNA. Since HERV-K Gag expression is induced by HIV-1 Tat in T cells, induced HERV-K proteins could affect HIV-1 ...
Kazuaki Monde, Hiromi Terasawa, Yusuke Nakano, Ferri Soheilian, Kunio Nagashima, Yosuke Maeda, Akira Ono   +6 more
doaj   +1 more source

Top 20 most strongly correlated pairs of Gag-Gag positions.

, 2015
Top 20 most strongly correlated pairs of Gag-Gag positions.
Ronald M. Levy (136784), Max W. Chang (244497), Glenn Oliveira (727212), Jinyun Yuan (649258), Bruce E. Torbett (244500), Jason F. Okulicz (220314), William F. Flynn (727211), Zhiqiang Tan (544538)   +7 more
core   +1 more source

Puerarin‑Loaded pH‑Responsive ZIF‑90 Nanoparticles Ameliorate Osteoporosis via Enhancing H3K18 Lactylation and Suppressing Aberrant Osteoclast Activation

Advanced Science, EarlyView.
Schematic illustration of the mechanism by which ZIF‐90@PU alleviates osteoporosis via H3K18la‐mediated NFATc1 pathway suppression. ABSTRACT Osteoporosis is characterized by dysregulated osteoclast activity, leading to excessive bone resorption and structural damage.
Jiajia Lu, Yue Xi, Sheng Wang, Ye Chen, Jiajie Yang, Xiaojian Shi   +5 more
wiley   +1 more source

Lower lip reconstruction with the tongue flap: surgical technique and long-term results

B-ENT, 2007
Lower lip reconstruction with the tongue flap: surgical technique and long-term results. Objective: To demonstrate the functional long-term results after reconstruction of the lower lip with the tongue flap.
A. Minovi, A. Ural, M. Kollert, W. Draf, U. Bockmuehl   +4 more
doaj   +2 more sources

Investigating the expression of HERV-K env, np9, gag, and rec in bladder cancers

Infectious Agents and Cancer
Objective Bladder cancer (BCa) has become a growing concern worldwide, highlighting the importance of early detection and new treatment methods. Recent studies have shown that viruses from the HERV family play a significant role in the development of ...
Fariba Rafiei, Navid Masoumi, Ebrahim Faghihloo   +2 more
doaj   +1 more source

Salvianolic Acid a Disrupts the HSP90α‐AKT‐PERK Ternary Complex to Alleviate Atherosclerosis by Activating Endoplasmic Reticulum Stress of Senescent Vascular Smooth Muscle Cells

Advanced Science, EarlyView.
Salvianolic acid A (SAA) selectively induces senescent vascular smooth muscle cell apoptosis, alleviating atherosclerosis. Mechanistically, SAA targets heat shock protein 90 alpha (HSP90α) to disrupt the protein inase B (AKT)‐PRKR‐Like Endoplasmic Reticulum Kinase (PERK) scaffold, driving ubiquitin‐proteasome‐dependent AKT degradation.
Xiuya Guan, Mengkai Lu, Xinhai Cui, Dawei Zhang, Lei Zhang, Lin Lin, Yuan Li, Yuanlong Hu, Chao Li   +8 more
wiley   +1 more source

Depth‐to‐Areal Staging Heterogeneity Preceding Lithium Plating in Graphite Anodes Revealed by Operando Imaging

Advanced Science, EarlyView.
Fast charging drives graphite anodes far from equilibrium, yet where lithium plating begins has remained hidden. Operando optical microscopy here reveals that neighboring regions advance through the staging sequence asynchronously, and that domains reaching advanced lithiation earliest become the preferential sites where plating initiates.
Tae Young Choi, Juyoung Kim, Vithiya Muralidharan, Seungwoo Choi, Jeongwoo Seo, Seungwoo Ryu, Myeongjun Choi, Hyun‐Wook Lee   +7 more
wiley   +1 more source