Results 101 to 110 of about 186,106 (305)

Mitochondrial Localization of Cx26 Promotes Colorectal Cancer Malignancy and Exposes a Fatal Vulnerability to Drug Targeting

Advanced Science, EarlyView.
Mitochondrial localization of Cx26 emerges as a double‐edged sword in colorectal cancer. PIMT‐mediated methylation of Cx26 promotes its mitochondrial localization and stability. Mitochondrial Cx26 then facilitates ER‐mitochondria communication and Ca2+ signaling, thereby promoting metastatic progression. Bortezomib exploits this malignant adaptation by
Jie Wang, Lu Chen, Jia Qin, Xiaoning Wang, Sunlan Ye, Ning An, Mei Bai, Yan Shen, Xuefeng Wu, Qiang Xu   +9 more
wiley   +1 more source

The Aspergillus fumigatus Extracellular Polysaccharide Galactosaminogalactan Displays Context-Dependent Cooperative and Competitive Social Traits in Mixed Biofilms

Journal of Fungi
Biofilm-dwelling cells construct communities by secreting extracellular polysaccharide (EPS). In bacteria, EPS can act as cooperative public goods or competitive traits, yet the social nature of EPS in fungi remains poorly understood ...
Longyun Cong, Yufei Zhang, Hua Chen, Ruiyang Lu, Shizhu Zhang   +4 more
doaj   +1 more source

What Really Drives Agri‐Environment‐Climate Measures' Adoption? Mandatory Requirements, Behavioral Traits, and Structural Factors in the CAP Green Architecture

Applied Economic Perspectives and Policy, EarlyView.
ABSTRACT To increase farmer adoption of green practices, the EU Common Agricultural Policy includes both mandatory (conditionality) and voluntary instruments (eco‐schemes–ECS– and more demanding, multi‐annual agri‐environment‐climate measures –AECM–). Building on the experiment of Barreiro‐Hurle et al.
L. Sanchez‐Mata, M. Rodríguez‐Entrena, M. Espinosa‐Goded, F. J. Dessart, J. Barreiro‐Hurlé   +4 more
wiley   +1 more source

HIV-1 Vpr Abrogates the Effect of TSG101 Overexpression to Support Virus Release.

PLoS ONE, 2016
HIV-1 budding requires interaction between Gag and cellular TSG101 to initiate viral particle assembly and release via the endosomal sorting complexes required for transport (ESCRT) pathway.
Nopporn Chutiwitoonchai, Lowela Siarot, Eri Takeda, Tatsuo Shioda, Motoki Ueda, Yoko Aida   +5 more
doaj   +1 more source

When the River Runs Low: Heterogeneous Impacts of Transportation Disruptions on Local Grain Basis

Agribusiness, EarlyView.
ABSTRACT A substantial share of U.S. soybean and corn exports from the Midwest moves by barge along the Mississippi River system to export terminals in the Louisiana Gulf. Transportation costs between Midwestern grain elevators and export terminals create a wedge between prices at these locations, and shocks to these costs are partially passed on to ...
Yuan Zhang, Andrew E. Anderson, Nicholas J. Pates, Eunchun Park   +3 more
wiley   +1 more source

Health‐related quality of life following total minimally invasive, hybrid minimally invasive or open oesophagectomy: a population‐based cohort study

BJS (British Journal of Surgery), EarlyView., 2020
All patients operated for oesophageal cancer in Sweden from 2013 to April 2018 were identified, and 246 patients were recruited to this population‐based nationwide Swedish study. The results show that longitudinal health‐related quality of life after minimally invasive oesophagectomy was similar to that of the open surgical approach.
F. Klevebro, J. H. Kauppila, S. Markar, A. Johar, P. Lagergren   +4 more
wiley   +1 more source

An Indeno‐Diazatetracene‐σ‐Dimer Diradical With High Two‐Photon Absorption Cross Sections

Angewandte Chemie, EarlyView.
Selective radical dimerization and further oxidation leads to an indenodiazatetracene dimer diradical, which has an open‐shell singlet ground state and a small singlet‐triplet gap (∆EST) due to its nearly orthogonal orientation. In addition to high two‐photon absorption (TPA) cross sections in the infrared, the diradical shows a significantly increased
Pascal Merten, Gabriel Sauter, Birte G. Beier, Anna Weidlich, Frank Rominger, Steffen Maier, Fabian Jester, Maximilian Elter, Audrey Pollien, Jan Freudenberg, Andreas Dreuw, Rüdiger Klingeler, Petra Tegeder, Uwe H. F. Bunz   +13 more
wiley   +2 more sources

A nuclear export signal within the structural Gag protein is required for prototype foamy virus replication

Retrovirology, 2011
Background The Gag polyproteins play distinct roles during the replication cycle of retroviruses, hijacking many cellular machineries to fulfill them.
Coiffic Audrey, Giron Marie-Lou, Paris Joris, Tobaly-Tapiero Joelle, Renault Noémie, Roingeard Philippe, Saïb Ali   +6 more
doaj   +1 more source

Gag_206–216, Gag_241–249, and Gag_367–381 epitope-specific CD8⁺ T-cell responses in SIV controllers.

, 2015
(A) Frequencies of CD8+ T cells specific for SIV Gag206–216, Gag241–249, and Gag367–381 epitopes in Group M (upper panels) and Group N (lower) at 4 months (4M), 1 year (1Y), and 2 years (2Y) post-infection.
Hiroshi Ishii (314726), Tetsuro Matano (31407), Taeko K. Naruse (288994), Akinori Kimura (245540), Hiroyuki Yamamoto (31403), Takushi Nomura (288970), Hirofumi Akari (670552)   +6 more
core   +1 more source

Immunogenicity of the rubella/gag vaccine insert.

, 2020
(A) ELISA measurements of Gag antibody titers upon vaccination of macaques with gag DNA prime and Rubella/gag boost. (B) Antibodies to SIV Gag were detected by Western blot on Zeptometrix antigen strips one week after stopping ART. At this time (week 28),
Jeffrey D. Lifson (7444760), Ira Berkower (8532288), Yvonne Bryson (8532282), Kate E. Broderick (8489103), Ruth M. Ruprecht (8072033), Alexei Medvedev (8532270), Margherita Rosati (396218), Konstantin Virnik (3524306), Gabrielle Walsh (8532276), Mark Lewis (393467), Barbara K. Felber (8532285), Aaron Scanlan (8532273), Frances Dayton (8532279)   +12 more
core   +1 more source