Results 91 to 100 of about 186,106 (305)

Detection of HIV-1 Genetic Variation in Gag Gene, Subtyping, and Phylogenetic Tree at Thi-Qar Province, South of Iraq

Medical Journal of Babylon
Background: HIV constitutes a major health problem for the individual and society and is a threat to public health. The World Health Organization aims to eliminate this threat by 2030.
Ahmed Hieran Ramadhan Al-Jabery, Bushra Jabbar Albadry   +1 more
doaj   +1 more source

Gag-Pol supplied in trans is efficiently packaged and supports viral function in human immunodeficiency virus type 1

, 2001
The intracellular trafficking and subsequent incorporation of Gag-Pol into human immunodeficiency virus type 1 (HIV-1) remains poorly defined. Gag-Pol is encoded by the same mRNA as Gag and is generated by ribosomal frameshifting.
S Crowe (13428231), C Hooker (13633312), D Harrich (13719703), M Hill (7674827), Johnson Mak (13082904)   +4 more
core  

Ilexoside K Ameliorates Atherosclerosis by Suppressing CD72hi Macrophages and Blocking CXCL12–CXCR4 Axis to Inhibit Endothelial Pyroptosis

Advanced Science, EarlyView.
CD72hi macrophages drive endothelial pyroptosis and accelerate atherosclerosis through CXCL12–CXCR4‐mediated immune–vascular crosstalk. Ilexoside K suppresses this pathogenic communication by modulating CXCR4‐dependent endothelial responses, reducing inflammation and plaque progression. These findings reveal a macrophage–endothelial regulatory axis and
Xingling He, Sijing Li, Jiahui Chen, Liyu Lin, Xinyu Li, Xiaojiao Zhang, Yihui Zhang, Xingling Chen, Jinjian Guo, Zhongqi Yang, Lu Lu, Shihao Ni   +11 more
wiley   +1 more source

Association of HIV-1 gag with LAMP-1 does not protect Gag protein from degradation, but increases Gag mRNA production.

, 2014
A) HEK 293 cells were transfected with native gag (gagN) or LAMP/gag. After 48 hours, the expression of Gag protein was analyzed by western blotting, by staining with mouse anti-Gag antibody, followed by HRP-conjugated anti-mouse IgG.
Jorge Luiz Santos Gonçalves (578468), Ernesto Torres de Azevedo Marques Jr (578470), Ligia Maria Torres Peçanha (578469), Maria Notomi Sato (183519), Luciana Barros de Arruda (37086), Flavio Lemos Matassoli (578466), Rodrigo Maciel da Costa Godinho (578465), Paula Ordonhez Rigato (183494), J. Thomas August (36342), Milton Maciel Jr (183497), Carolina Gonçalves de Oliveira Lucas (578467)   +10 more
core   +1 more source

Biological function of p58(gag)

, 1997
P58$\rm\sp{gag}$ is a truncated retroviral Gag protein located at the microfilament-membrane interface of the MAT-C1 ascites subline of the 13762 rat mammary adenocarcinoma. It contains proline-rich regions that are similar to the consensus sequences for
Huang, Jiaqi
core   +3 more sources

A Multi‐Targeting Chimeric Antigen Receptor‐T Cell Platform to Overcome Antigen Heterogeneity in the Treatment of Non‐Small Cell Lung Cancer

Advanced Science, EarlyView.
A dual‐transmembrane Bicephali CAR‐T platform simultaneously targets CD276 and NKG2D ligands to address antigen heterogeneity in non‐small cell lung cancer. By improving immune synapse formation, mitochondrial fitness, antioxidant capacity, and stem‐like persistence, this design enhances durable tumor control and provides a versatile strategy to ...
Lina Wang, Yanlei Zhang, Shuixiu Peng, Chenchen Hou, Huaqi Guo, Tianyu Zhou, Alex H. Chang, Lifeng Yan, Weining Xiong   +8 more
wiley   +1 more source

Real-time visualization of HIV-1 GAG trafficking in infected macrophages.

PLoS Pathogens, 2008
HIV-1 particle production is driven by the Gag precursor protein Pr55(Gag). Despite significant progress in defining both the viral and cellular determinants of HIV-1 assembly and release, the trafficking pathway used by Gag to reach its site of assembly
Karine Gousset, Sherimay D Ablan, Lori V Coren, Akira Ono, Ferri Soheilian, Kunio Nagashima, David E Ott, Eric O Freed   +7 more
doaj   +1 more source

Expression of Gag-Pol inhibits HIV budding.

, 2013
(A) Line diagram of the Gag and Gag-Pol proteins expressed by NL4-3*/TFter and NL4-3*/Gag-Polfuse/PRD25A, respectively. The upper line corresponds to the full-length p55 Gag protein, which contains p6, and is the only Gag-containing protein expressed by ...
Stephen J. Gould (336114), Xin Gan (336113)   +1 more
core   +1 more source

Neonatal Sevoflurane Exposure Induces Long‐Term Cognitive Impairment via Epigenetically Mediated MMP9 Activation and Perineuronal Net Disruption in the Hippocampal CA2

Advanced Science, EarlyView.
Hippocampal CA2 perineuronal nets ensheathing excitatory pyramidal neurons are selectively vulnerable to repeated neonatal sevoflurane exposure. Epigenetic upregulation of MMP9 via reduced H3K27me3 disrupts PNN integrity, impairs BDNF–TrkB signaling, and causes synaptic protein loss and dendritic spine deficits, leading to persistent social and spatial
Lirong Liang, Jiachen Wang, Taozhi Wang, Yanling Li, Youyi Zhao, Guanghui Hao, Peiqin Gong, Ruling Chen, Yilin Fang, Shengxi Wu, Haopeng Zhang, Hui Zhang   +11 more
wiley   +1 more source

Drug Repurposing for Treating NCOR‐Related Intellectual Disability

Advanced Science, EarlyView.
An autism‐associated NCOR1 heterozygous mutation upregulates NRGs and activates NRG backward signaling in hypothalamic GABAergic neurons in mouse models, leading to Gabra2 downregulation and cognitive deficits, which can be therapeutically targeted by repurposing FDA‐approved drugs.
Yan Kong, Wenjun Zhou, Yuxiang Sun, Zihan Huang, Zhiyue Liu, Udhaya Kumar. S, Chenyan Li, Yi Lu, Chengchuang Song, Veronica C. Ciliberto, Makenna Mack, Lana E. Kim, Zhaoyong Hu, Fang Luo, Aihua Cao, Zheng Sun   +15 more
wiley   +1 more source