Results 231 to 240 of about 7,491,489 (299)

Combining antibody conjugates with cytotoxic and immune‐stimulating payloads maximizes anti‐cancer activity

Molecular Oncology, EarlyView.
Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang, Dong Jun Koo, Peter M. Tessier, Greg M. Thurber   +3 more
wiley   +1 more source

Experience with the Jungfrau-1M detector at Diamond Light Source. [PDF]

J Synchrotron Radiat
Matheson J, Axford D, Bergamaschi A, Carulla M, Devenish N, Frisina N, Hinger V, Kedych V, Lane C, Mozzanica A, Gimenez-Navarro E, O'Hea J, Oram D, Owen RL, Perl D, Prescott A, Schmitt B, Scully S, Taylor A, Yendell G, Winter G.   +20 more
europepmc   +1 more source

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

Tumor mutational burden as a determinant of metastatic dissemination patterns

Molecular Oncology, EarlyView.
This study performed a comprehensive analysis of genomic data to elucidate whether metastasis in certain organs share genetic characteristics regardless of cancer type. No robust mutational patterns were identified across different metastatic locations and cancer types.
Eduardo Candeal, Andrea Moreno‐Manuel, Miguel Salvadó‐Pertierra, Cristina Santos‐Vivas, Rebeca Sanz‐Pamplona   +4 more
wiley   +1 more source

Altered Lipid and Neurotransmitter Metabolism as Potential Mechanisms of Weight Gain in Women With HIV Initiating INSTIs in a Pilot Study. [PDF]

J Acquir Immune Defic Syndr
Alvarez JA, Teeny S, Yang CA, Mehta CC, Yang Q, Jones DP, Go YM, Sheth A, Ofotokun I, Ali MK, Ziegler TR, Lahiri CD.   +11 more
europepmc   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Tofacitinib-Induced Weight Gain in Context: comment on the article by Wollenhaupt et al. [PDF]

ACR Open Rheumatol
Palmowski A, Buttgereit F, Simon D, Kleyer A, Drzeniek NM.   +4 more
europepmc   +1 more source

Serum 25-hydroxyvitamin D and health-related quality of life in patients with papillary thyroid carcinoma: a prospective cohort study. [PDF]

Front Nutr
Li Y, Wei Y, Zhao Z, Peng L, Li S, Wu J, Cao S, Yu N, Cai W, Wu Q, Li S, Yu MA.   +11 more
europepmc   +1 more source

Guidance and absorption of internal energy in Vivaldi antennas using multiple slots, full-band dividers, metamaterials, and distributed resistors. [PDF]

Sci Rep
Hoang H, Nguyen MH, Pham-Xuan V.
europepmc   +1 more source

Energy requirements of female sheep at increasing ages and fed at different concentrate levels. [PDF]

Trop Anim Health Prod
Brito Neto AS, Teixeira IAMA, Marcondes MI, Herbster CJL, Justino EDS, Bezerra LR, Santos SA, Oliveira RL, Pereira ES.   +8 more
europepmc   +1 more source