Results 121 to 130 of about 180,088 (293)
Interpreting the effects of DNA polymerase variants at the structural level
Molecular Oncology, EarlyView.Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi +7 more
wiley +1 more source
Molecular Oncology, EarlyView.Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary +1 more
wiley +1 more source
Molecular Oncology, EarlyView.Radiotherapy (RT) response depends on the DNA repair capacity of tumor and host cells. We show that circulating tumor cell (CTC) counts and apoptosis rates before and after RT predict treatment response and outcome, which can be accessed via easily accessible liquid biopsy approaches. Created in BioRender. Wikman, H.
Yvonne Goy +10 more
wiley +1 more source
Indonesian Journal of Education and PedagogyThis action research aimed to enhance the graph interpretation skills of 35 Grade 9 Apitong students of Baybay National High School in learning microeconomics through the I2 strategy.
Jojenn P. Calingacion +5 more
doaj +1 more source
Graph-Based Approaches for Prediction and Similarity Analysis
This thesis explores graph-based approaches for prediction and similarity analysis problems within networks and hypergraphs. While existing algorithms for link prediction in networks predominantly target the existence or weights of edges, our study ...
Lin Xing (7384631)
core +1 more source
Signal-flow-graph gain with respect to the general node of a graph
Electronics Letters, 1969 A new formula for the graph gain is given, which is more general than Mason's formula and enables the graph gain to be solved with respect to the general node of the graph that may also be the loop node.
openaire +1 more source
Godsil-McKay switchings for gain graphs
The Electronic Journal of Linear AlgebraWe introduce a switching operation, inspired by the Godsil-McKay switching, in order to obtain pairs of $G$-cospectral gain graphs, that are gain graphs cospectral with respect to every representation of the gain group $G$. For instance, for two signed graphs, this notion of cospectrality is equivalent to the cospectrality of their signed adjacency ...
Matteo Cavaleri +2 more
openaire +2 more sources
Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source