Results 121 to 130 of about 2,248,301 (258)

Targeting the EpCAM‐AXL axis to overcome drug resistance in lung cancer

Molecular Oncology, EarlyView.
Lung cancer cells often evade therapy by hijacking signaling pathways. We reveal that cleaved EpCAM (sEpCAM) stabilizes the oncogenic protein AXL, driving NF‐κB and STAT3‐mediated chemoresistance. This EpCAM‐AXL axis identifies a high‐risk patient subset with poor prognosis.
Alexa Guerrero‐Alba, Mark Shacker, Timothy P. Fleming, Michael A. Smith, Ross M. Bremner, Narendra V. Sankpal   +5 more
wiley   +1 more source

Characterization of therapeutic antibodies targeting lymphatic and vascular resistance factor for the treatment of hypervascularized and highly metastatic cancers

Molecular Oncology, EarlyView.
LVRF (lymphatic and vascular resistance factor) is a VEGFA splice variant upregulated in response to anti‐angiogenic therapy that fosters tumor adaptation through enhanced vascularization, lymphangiogenesis, and metastatic dissemination. Targeting LVRF with fully human neutralizing antibodies disrupts these processes and limits resistant tumor growth ...
Marion David, Arthur Karaulic, Audrey Bennetot, Clémence Fournier, Quentin Odet, Arthur Gouraud, Isabelle Bourget, Cédric Gaggioli, Sandy Giuliano, Frédéric Luciano, Olivier Léger, Zaki Sellam, Gilles Pagès   +12 more
wiley   +1 more source

Bond Graph Based Stability Analysis of a Railway Traction System [PDF]

, 2005
This paper emphasises the interest of the Bond Graph approach for analysis and system design of heterogeneous and multi-field devices. In particular, the local stability analysis of non linear systems can be directly derived from the linearised Causal ...
Sareni, Bruno, Gandanegara, Grace, Roboam, Xavier, Dauphin-Tanguy, Geneviève   +3 more
core  

USP7 inhibits FOXO1 activity in chronic lymphocytic leukaemia cells enhancing cell survival

Molecular Oncology, EarlyView.
CLL cells rely on BCR‐mediated signalling for survival and proliferation in part through suppression of FOXO1. FOXO1 activity is regulated by a plethora of post‐translational modifications including phosphorylation and ubiquitination. We demonstrated that dual inhibition of BCR signalling and the deubiquitinase USP7 activates FOXO1, modulating its ...
Hassan N.B. Almuhanna, Jodie Hay, Michael W. Moles, Lucy Clarke, Jennifer Cassels, Alison Sefcick, Alison M. McCaig, Heather G. Jørgensen, Alison M. Michie   +8 more
wiley   +1 more source

Tumour‐proximal deep serum proteomics identifies biomarkers associated with ovarian cancer

Molecular Oncology, EarlyView.
New biomarkers are needed for early ovarian cancer detection. Ovarian (tumour‐proximal) and peripheral vein serum from healthy women and patients with benign or malignant tumours underwent nanoparticle‐enriched deep proteomics. Ovarian serum yielded more protein identifications and revealed tumour‐reflective signatures.
Darren Lau, Daniel Pincher, Clifford Young, Nicholas Chappell, Noor A. Lokman, Parul Mittal, Leigh Donnellan, Martin K. Oehler, Doug A. Brooks, Peter Hoffmann   +9 more
wiley   +1 more source

A Text Classification Method Based on Combination of Information Gain and Graph Clustering

International Journal of Information and Communication Technology Research, 2019
Text classification has a wide range of applications such as: spam filtering, automated indexing of scientific articles, identifying the genre of documents, news monitoring, and so on.
Alireza Abdollahpouri, Shadi Rahimi, Fatemeh Zamani, Parham Moradi   +3 more
doaj  

Graph neural network approach with spatial structure to anomaly detection of network data

Journal of Big Data
Network anomaly detection using graph-structured data is a critical task in data mining and cybersecurity, involving the identification of unusual patterns within a network by analyzing its structure as a graph.
Hao Zhang, Yun Zhou, Huahu Xu, Jiangang Shi, Xinhua Lin, Yiqin Gao   +5 more
doaj   +1 more source

Enhancing graph interpretation skills of Grade 9 students in learning microeconomics through I2 strategy

Indonesian Journal of Education and Pedagogy
This action research aimed to enhance the graph interpretation skills of 35 Grade 9 Apitong students of Baybay National High School in learning microeconomics through the I2 strategy.
Jojenn P. Calingacion, Alyssa Lira M. Dacera, Melissa G. Castro, Joshua C. Lubay, Rona Flor Fatima C. Bug-os, Jay C. Bansale   +5 more
doaj   +1 more source

Single‐molecule DNA flow‐stretch assays for high‐throughput DNA–protein interaction studies

FEBS Open Bio, EarlyView.
We describe an optimised single‐molecule DNA flow‐stretch assay that visualises DNA–protein interactions in real time. Linear DNA fragments are tethered to a surface and stretched by buffer flow for fluorescence imaging. Using λ and φX174 DNA, this protocol enhances reproducibility and accessibility, providing a versatile approach for studying diverse ...
Ayush Kumar Ganguli, Mohammad Nour Alsamsam, Ugnė Bagdonaitė, Van Truc Vu, Chun‐Jen Huang, Polina Kuzhir, Mindaugas Zaremba, Aurimas Kopūstas, Marijonas Tutkus   +8 more
wiley   +1 more source

Gauge-programmable mode selection in non-Hermitian directed-graph networks

JPhys Photonics
Programmable mode selection is essential for integrated photonic networks, yet selectively isolating individual modes without delicate balancing of gain and loss remains challenging.
Wenwen Liu, Shuang Zhang
doaj   +1 more source