Results 101 to 110 of about 176,563 (257)

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source

Graph Combinatorial Optimization Problems for Blockchain Transaction Network Analysis

Mathematics
Open data makes it possible to gain insights into the transaction patterns of blockchain projects. These patterns can be modeled as transaction networks, which support a wide range of analytical techniques.
Michael Palk, Stefan Voß
doaj   +1 more source

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

The \(\mathscr{G}\)-average of adjacency and Laplacian polynomials of a graph

The American Journal of Combinatorics
Let \(\mathscr{G}\) be a finite multiplicative group of quaternion unit \(U(\mathbb{H})\). The \(\mathscr{G}\)-average of adjacency (resp., Laplacian) polynomial of a graph \(G\) is defined as the arithmetic mean of the characteristic polynomials of
Yaoping Hou, Wenjun Xie
doaj   +1 more source

Signal-flow-graph gain with respect to the general node of a graph

Electronics Letters, 1969
A new formula for the graph gain is given, which is more general than Mason's formula and enables the graph gain to be solved with respect to the general node of the graph that may also be the loop node.
openaire   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

Correlation-Induced Accessibility Bridges in Biomedical Networks: A Proof-of-Concept Relational Graph Model

Entropy
Complex diseases often involve distributed interactions among biological regions, physiological systems, imaging phenotypes, and clinical variables that are not fully captured by anatomical proximity, isolated biomarkers, or conventional feature-based ...
Roxana Irina Iancu, Călin Gheorghe Buzea, Florin Nedeff, Diana Mirilă, Valentin Nedeff, Mirela Panainte-Lehaduș, Claudia Manuela Tomozei, Maricel Agop, Alina Ștefania Doboș, Dragoş Petru Teodor Iancu, Lăcrămioara Ochiuz, Decebal Vasincu   +11 more
doaj   +1 more source

Totally frustrated states in the chromatic theory of gain graphs

European Journal of Combinatorics, 2009
We generalize proper coloring of gain graphs to totally frustrated states, where each vertex takes a value in a set of `qualities' or `spins' that is permuted by the gain group. (An example is the Potts model.) The number of totally frustrated states satisfies the usual deletion-contraction law but is matroidal only for standard coloring, where the ...
openaire   +3 more sources

Tumor B‐cell infiltration in platinum‐treated advanced muscle‐invasive urothelial carcinoma

Molecular Oncology, EarlyView.
Bladder tumors with higher pretreatment memory B‐cell infiltration were linked to longer survival after cisplatin chemotherapy, but not carboplatin. These tumors also showed more organized immune structures (tertiary lymphoid structures) and a shared pro‐inflammatory B‐cell‐rich community, suggesting that memory B cells may help identify patients most ...
Konrad Stawiski, Júlia Perera‐Bel, Alejo Rodriguez‐Vida, Nuria Juanpere, Jihyun Lee, Daniel E. Michaud, Jennifer L. Guerriero, Kent W. Mouw, Aristotelis Bamias, Filipe L. F. Carvalho, Joaquim Bellmunt   +10 more
wiley   +1 more source