Results 91 to 100 of about 176,563 (257)

Longitudinal circulating tumor DNA profiling in patients with advanced endometrial cancer using an off‐the‐shelf targeted NGS panel

Molecular Oncology, EarlyView.
Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena, Karin Teien Lande, Eva Diaz, Ana Vilar, Juan Cueva, Efigenia Arias, Victoria Sampayo, Alicia Abalo, Nerea González, Eva Colás, Antonio Gil‐Moreno, Miguel Abal, Gema Moreno‐Bueno, Therese Sørlie, Kristina Lindemann, Laura Muinelo‐Romay   +15 more
wiley   +1 more source

Fuzzy Computational Analysis of Fuzzy Tadpole Graph

Journal of Mathematics
In this paper, we explore the application of fuzzy topological indices to the fuzzy tadpole graph TA,B, a hybrid structure that combines the cyclic and path-like components within a fuzzy framework.
Shama Liaqat, Zeeshan Saleem Mufti, Yilun Shang   +2 more
doaj   +1 more source

Bounds and extremal graphs for the energy of complex unit gain graphs

Linear Algebra and its Applications
A complex unit gain graph ($ \mathbb{T} $-gain graph), $ Φ=(G, φ) $ is a graph where the gain function $ φ$ assigns a unit complex number to each orientation of an edge of $ G $ and its inverse is assigned to the opposite orientation. The associated adjacency matrix $ A(Φ) $ is defined canonically. The energy $ \mathcal{E}(Φ) $ of a $ \mathbb{T} $-gain
Aniruddha Samanta, M. Rajesh Kannan
openaire   +2 more sources

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source

Context-Aware Knowledge Graph Learning for Point-of-Interest Recommendation

ISPRS International Journal of Geo-Information
Existing point-of-interest (POI) recommendation methods often fail to capture complex contextual dependencies and suffer from severe data sparsity in location-based social networks (LBSNs).
Yan Zhou, Di Zhang, Kaixuan Zhou, Pengcheng Han   +3 more
doaj   +1 more source

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

PDASTSGAT: An STSGAT-Based Multipath Data Scheduling Algorithm

Algorithms
How to select the transmitting path in MPTCP scheduling is an important but open problem. This paper proposes an intelligent data scheduling algorithm using spatiotemporal synchronous graph attention neural networks to improve MPTCP scheduling.
Sen Xue, Chengyu Wu, Jing Han, Ao Zhan
doaj   +1 more source

Godsil-McKay switchings for gain graphs

The Electronic Journal of Linear Algebra
We introduce a switching operation, inspired by the Godsil-McKay switching, in order to obtain pairs of $G$-cospectral gain graphs, that are gain graphs cospectral with respect to every representation of the gain group $G$. For instance, for two signed graphs, this notion of cospectrality is equivalent to the cospectrality of their signed adjacency ...
Matteo Cavaleri, Alfredo Donno, Stefano Spessato   +2 more
openaire   +2 more sources