Results 91 to 100 of about 180,088 (293)
, 2018 (a) Bandwidth and peak contrast gain for the model photoreceptor with unshifted conductances (dashed black line) where light-induced conductance has been increased to depolarise to four membrane potentials (colour circles).
Francisco J. H. Heras (3224298) +2 more
core +1 more source
Molecular Oncology, EarlyView.Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson +9 more
wiley +1 more source
COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells
Molecular Oncology, EarlyView.This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos +6 more
wiley +1 more source
Molecular Oncology, EarlyView.Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau +36 more
wiley +1 more source
Adaptive Graph Learning with Multimodal Fusion for Emotion Recognition in Conversation
BiomimeticsRobust emotion recognition is a prerequisite for natural, fluid human–computer interaction, yet conversational settings remain challenging because emotions are shaped simultaneously by global topic flow and local speaker-to-speaker dependencies. Here, we
Jian Liu +6 more
doaj +1 more source
Interrogating the immune landscape of microsatellite stable RAS‐mutated colon cancer
Molecular Oncology, EarlyView.COLOSSUS project RAS‐mutated MSS colon cancer study explored transcriptomics and immune cell density by immunohistochemistry (IHC), Immunoscore (IS), ISIC/TuLIS scores, mutation counts, and detected different prevalences but similar microenvironment composition across immune markers with clinical relevance for future immunotherapy combination ...
Rodrigo Dienstmann +61 more
wiley +1 more source
Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma
Molecular Oncology, EarlyView.The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic +5 more
wiley +1 more source
A switching method for constructing cospectral gain graphs
Discrete MathematicsA gain graph over a group $G$, also referred to as $G$-gain graph, is a graph where an element of a group $G$, called gain, is assigned to each oriented edge, in such a way that the inverse element is associated with the opposite orientation. Gain graphs can be regarded as a generalization of signed graphs, among others.
Aida Abiad +2 more
openaire +4 more sources
Molecular Oncology, EarlyView.Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute +4 more
wiley +1 more source
A Mathematical Bibliography of Signed and Gain Graphs and Allied Areas [PDF]
The Electronic Journal of Combinatorics, 2018 A signed graph is a graph whose edges are labeled by signs. This is a bibliography of signed graphs and related mathematics.Several kinds of labelled graph have been called "signed" yet are mathematically very different. I distinguish four types:Group-signed graphs: the edge labels are elements of a 2-element group and are multiplied around a polygon ...
openaire +2 more sources