Results 111 to 120 of about 2,248,301 (258)
Molecular Oncology, EarlyView.High‐risk bladder cancer is typically treated with Bacillus Calmette‐Guérin (BCG), but 30–40% of patients relapse. No FDA‐ or CE‐approved biomarkers currently predict or prognosticate BCG failure. We systematically reviewed the literature and identified 72 eligible studies, revealing several promising biomarkers associated with BCG treatment response ...
Rui Ribeiro‐Pereira +7 more
wiley +1 more source
Molecular Oncology, EarlyView.Taxanes are widely used chemotherapeutics whose effects on cellular mechanics remain poorly understood. We show that paclitaxel induces rapid cellular contraction by promoting GEF‐H1 dissociation from microtubules and non‐muscle myosin II activation through RhoA/ROCK.
Gloria Asensio‐Juárez +5 more
wiley +1 more source
PDASTSGAT: An STSGAT-Based Multipath Data Scheduling Algorithm
AlgorithmsHow to select the transmitting path in MPTCP scheduling is an important but open problem. This paper proposes an intelligent data scheduling algorithm using spatiotemporal synchronous graph attention neural networks to improve MPTCP scheduling.
Sen Xue, Chengyu Wu, Jing Han, Ao Zhan
doaj +1 more source
Molecular Oncology, EarlyView.Isocitrate dehydrogenase 1 (IDH1) mutations are highly recurrent in multiple human cancer types, including cholangiocarcinoma and glioma. IDH1 R132C is the most common IDH1 mutation in cholangiocarcinoma and likely arises from APOBEC3A‐ or APOBEC3B‐mediated deamination.
Kelly E. Butler +3 more
wiley +1 more source
The \(\mathscr{G}\)-average of adjacency and Laplacian polynomials of a graph
The American Journal of CombinatoricsLet \(\mathscr{G}\) be a finite multiplicative group of quaternion unit \(U(\mathbb{H})\). The \(\mathscr{G}\)-average of adjacency (resp., Laplacian) polynomial of a graph \(G\) is defined as the arithmetic mean of the characteristic polynomials of
Yaoping Hou, Wenjun Xie
doaj +1 more source
Molecular Oncology, EarlyView.This study identifies ARHGAP5, in addition to the frequently mutated ARHGAP35, as significantly mutated in endometrial cancer. Mutations in both genes co‐occur and are associated with their correlated downregulation. Functional CRISPR studies show that both paralogs regulate similar pathways, including actin cytoskeleton organization.
Mathilde Pinault +12 more
wiley +1 more source
Graph Combinatorial Optimization Problems for Blockchain Transaction Network Analysis
MathematicsOpen data makes it possible to gain insights into the transaction patterns of blockchain projects. These patterns can be modeled as transaction networks, which support a wide range of analytical techniques.
Michael Palk, Stefan Voß
doaj +1 more source
Molecular Oncology, EarlyView.Incomplete microwave ablation (iMWA) of liver cancer triggers a biphasic progression in residual tumors. At Day 3, the microenvironment is characterized by acute inflammatory responses and extracellular matrix (ECM) remodeling. By Day 14, a profound shift occurs toward oncogenic signal transduction and immunosuppression, marked by macrophage ...
Yu Liu +9 more
wiley +1 more source
Molecular Oncology, EarlyView.The kinase SRPK1 directly interacts with the protein TOPBP1 and regulates the pre‐mRNA splicing of WIZ thereby contributing to the activation of the ATR/CHK1 replicative checkpoint in response to replicative stress. This allows cancer cells' genomic stability and survival.
Amani Shreim +17 more
wiley +1 more source
Graph Drawing Techniques for Geographic Visualization [PDF]
, 2004 Geovisualizers often need to represent data that consists of items related together. Such data sets can be abstracted to a mathematical structure, the graph.
Rodgers, Peter
core