Results 81 to 90 of about 2,248,301 (258)
Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining
Molecular Oncology, EarlyView.IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis +3 more
wiley +1 more source
Graph Pattern Matching: From Intractable to Polynomial Time [PDF]
, 2010 Graph pattern matching is typically defined in terms of sub-graph isomorphism, which makes it an np-complete problem. Moreover, it requires bijective functions, which are often too restrictive to characterize patterns in emerging applications. We propose
Li, Jianzhong +5 more
core
Negation Switching Equivalence in Signed Graphs [PDF]
, 2010 Unless mentioned or defined otherwise, for all terminology and notion in graph theory the reader is refer to [8].
Reddy, Siva Kota
core +1 more source
Finding novel vulnerabilities of hypomorphic BRCA1 alleles
Molecular Oncology, EarlyView.Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder +10 more
wiley +1 more source
Gain and Pain in Graph Partitioning: Finding Accurate Communities in Complex Networks
AlgorithmsThis paper presents an approach to community detection in complex networks by simultaneously incorporating a connectivity-based metric and Max-Min Modularity.
Arman Ferdowsi, Maryam Dehghan Chenary
doaj +1 more source
MITF maintains genome stability in nonmelanocyte lineages
Molecular Oncology, EarlyView.MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir +13 more
wiley +1 more source
International Journal of Reconfigurable Computing, 2011 Task graph scheduling for reconfigurable hardware devices can be defined as finding a schedule for a set of periodic tasks with precedence, dependence, and deadline constraints as well as their optimal allocations on the available heterogeneous hardware ...
Ikbel Belaid +2 more
doaj +1 more source
Graph-based pattern identification from architecture change logs [PDF]
, 2012 Service-based architectures have become commonplace, creating the need to address their systematic maintenance and evolution. We investigate architecture change representation, primarily focusing on the identification of change patterns that support the ...
Pooyan Jamshidi (5276344) +8 more
core +2 more sources
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
FUDMA Journal of Accounting and Finance Research (FUJAFR)Purpose: This study examines how reported detection performance in financial crime machine learning depends on the evaluation protocol and assesses when relational structure adds detection value.
Olubunmi Grace Oni +2 more
doaj +1 more source