Results 81 to 90 of about 915,611 (273)

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

open access: yesMolecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra   +10 more
wiley   +1 more source

Graph-Based Divide and Conquer Method for Parallelizing Spatial Operations on Vector Data

open access: yesRemote Sensing, 2014
In computer science, dependence analysis determines whether or not it is safe to parallelize statements in programs. In dealing with the data-intensive and computationally intensive spatial operations in processing massive volumes of geometric features ...
Xiaochen Kang, Xiangguo Lin
doaj   +1 more source

DHPV: a distributed algorithm for large-scale graph partitioning

open access: yesJournal of Big Data, 2020
Big graphs are part of the movement of “Not Only SQL” databases (also called NoSQL) focusing on the relationships between data, rather than the values themselves.
Wilfried Yves Hamilton Adoni   +4 more
doaj   +1 more source

Biased graphs. I. Bias, balance, and gains

open access: yesJournal of Combinatorial Theory, Series B, 1989
A biased graph is a graph with a class of its circles (simple closed paths), called balanced, having the property that, whenever the union of two balanced circles is a theta graph, the third circle in the union is also balanced. A gain graph is a graph in which each edge has a gain, i.e.
openaire   +2 more sources

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

open access: yesMolecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice   +16 more
wiley   +1 more source

Comparison and AI-based prediction of graph comprehension skills based on the visual strategies of first-year physics and medicine students

open access: yesPhysical Review Physics Education Research
Graphical representations of data are common in many disciplines. Previous research has found that physics students appear to have better graph comprehension skills than students from social science disciplines, regardless of the task context.
Verena Ruf   +9 more
doaj   +1 more source

Meningkatkan Kemampuan Bekerja dengan Grafik melalui Pembelajaran Kinematika

open access: yesJurnal Pendidikan: Teori, Penelitian, dan Pengembangan, 2019
: This research examines the increase of students’ ability in working with graph. This research is conducted by involving 58 students in class X SMA Negeri 5 Malang as the subjects.
Nurul Hidayah   +2 more
doaj   +1 more source

Dynamics of one-cycle controlled Ćuk converters [PDF]

open access: yes, 1995
One-cycle control is a nonlinear control method. The flow-graph modeling technique is employed to study the large-signal and small-signal dynamic behavior of one-cycle controlled switching converters.
Smedley, Keyue M., Ćuk, Slobodan
core  

Matroids of gain graphs in applied discrete geometry [PDF]

open access: yesTransactions of the American Mathematical Society, 2015
A Γ \Gamma -gain graph is a graph whose oriented edges are labeled invertibly from a group Γ \Gamma . Zaslavsky proposed two matroids associated with Γ \Gamma -gain graphs, called frame matroids and lift matroids, and investigated linear representations of them.
openaire   +2 more sources

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

open access: yesMolecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon   +13 more
wiley   +1 more source

Home - About - Disclaimer - Privacy