Results 101 to 110 of about 633 (112)

Efficient synthesis of galactosylceramide analogues for iNKT cell stimulation

Bioorganic & Medicinal Chemistry Letters, 2010
Glycolipids are potential antigens for iNKT cells recognition and demonstrate important roles in both innate and adaptive immunity. However, the difficulties in the preparation of pure configuration defined glycolipids limit the exploration of their different profiles in activating iNKT cells.
Wenlan, Chen, Chengfeng, Xia, Li, Cai, Peng George, Wang   +3 more
openaire   +2 more sources

Clinical Trials with α-Galactosylceramide (KRN7000) in Advanced Cancer

2011
For over a century, research has sought ways to boost the immune system of cancer patients in order to eradicate tumors that arose after escaping presumptive immunosurveillance. With increasing knowledge of the immune system, immunotherapeutic strategies to break tolerance to the tumor evolved from largely nonspecific to more specific and increasingly ...
Schneiders, Famke L., Scheper, Rik J., Bontkes, Hetty J., von Blomberg, B. Mary E., Eertwegh, Alfons J.M., de Gruijl, Tanja D., Van Der Vliet, Hans J.   +6 more
openaire   +5 more sources

Liver Injury After Invariant NKT Cell Activation by Free Alpha-galactosylceramide and Alpha-galactosylceramide-loaded Dendritic Cells.

Anticancer research, 2017
Both free alpha-galactosylceramide (αGalCer) and αGalCer-loaded dendritic cells (DCG) activate invariant natural killer T (iNKT) cells to varying degrees, with αGalCer inducing liver injury. We sought to evaluate liver injury by these two pathways.Mice were injected with αGalCer or DCG followed by analysis of serum alanine transaminase (ALT) activity ...
Hiroshi, Hasegawa, Kimihiro, Yamashita, Dai, Otsubo, Yoshihiro, Kakeji   +3 more
openaire   +1 more source

Galactosylceramide sulfotransferase

1997
Dietmar Schomburg, Dörte Stephan
openaire   +1 more source

The effect of alpha-galactosylceramide upon allogenic rejection

Transplantation Proceedings, 2001
K, Seino, K, Yanagisawa, H, Taniguchi, Y, Takada, K, Yuzawa, M, Otsuka, K, Fukao   +6 more
openaire   +2 more sources

Galactosylceramide sulfotransferase

2007
openaire   +1 more source

[Galactosylceramide synthase (CGT) knockout mouse].

Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme, 1999
openaire   +1 more source

Krabbe disease/galactosylceramide lipidosis/globoid cell leukodystrophy

2020
openaire   +1 more source

Krabbe disease/galactosylceramide lipidosis/globoid cell leukodystrophy

2011
openaire   +2 more sources

An α-galactosylceramide nose job shapes up iNKT cells.

Immunotherapy, 2012
de Bruin, Renée C G, Schneiders, Famke L, Santegoets, Saskia J A M, Verheul, Henk M W, de Gruijl, Tanja D, van der Vliet, Hans J   +5 more
openaire   +3 more sources