Results 1 to 10 of about 8,347 (118)

Spatial and temporal brain biodistribution of neuropathogenic sphingolipids of Krabbe disease [PDF]

Journal of Lipid Research
Glycosphingolipids are essential lipids enriched in the outer leaflet of the plasma membrane, particularly those forming the myelin sheaths. Disorders impacting the glycosphingolipid metabolism cause devastating demyelinating diseases.
Tingting Yan, Shih-Chang Hsueh, Salma Begum, Narayana Chelakkara Venkiteswaran, Justin Ellenburg, Boone M. Prentice, Gustavo H.B. Maegawa   +6 more
doaj   +2 more sources

Genetic Characterization of the Acidic and Neutral Glycosphingolipid Biosynthetic Pathways in Neurospora crassa

Microorganisms, 2023
Fungal glycosphingolipids (GSLs) are important membrane components which play a key role in vesicle trafficking. To assess the importance of GSLs in the fungal life cycle, we performed a mutant phenotypic study of the acidic and neutral GSL biosynthetic ...
Jannatul F. Shoma, Ben Ernan, Griffin Keiser, Christian Heiss, Parastoo Azadi, Stephen J. Free   +5 more
doaj   +1 more source

Human Brain Lipidomics: Investigation of Formalin Fixed Brains

Frontiers in Molecular Neuroscience, 2022
Human brain lipidomics have elucidated structural lipids and lipid signal transduction pathways in neurologic diseases. Such studies have traditionally sourced tissue exclusively from brain bank biorepositories, however, limited inventories signal that ...
Aaron W. Beger, Kathleen A. Hauther, Beatrix Dudzik, Randall L. Woltjer, Randall L. Woltjer, Paul L. Wood   +5 more
doaj   +1 more source

The PGRMC1 Antagonist AG-205 Inhibits Synthesis of Galactosylceramide and Sulfatide

Cells, 2021
Sulfatide synthesis in the human renal cancer cell line SMKT-R3 was strongly inhibited in the presence of low µM concentrations of AG-205, a progesterone receptor membrane component 1 (PGRMC1) antagonist.
Lihua Wang-Eckhardt, Ivonne Becker, Matthias Eckhardt   +2 more
doaj   +1 more source

Horse-Derived Ceramide Accentuates Glucosylceramide Synthase and Ceramide Synthase 3 by Activating PPARβ/δ and/or PPARγ to Stimulate Ceramide Synthesis

Biomedicines, 2023
Horse-derived ceramide (HC), which contains galactosylceramides as its main component, significantly improves skin symptoms when applied topically to patients with atopic dermatitis. We speculated that efficacy resulted from the amelioration of epidermal
Tami Igarashi, Hiroki Yanagi, Masayuki Yagi, Masamitsu Ichihashi, Genji Imokawa   +4 more
doaj   +1 more source

Qualitative and Quantitative Study of Glycosphingolipids in Human Milk and Bovine Milk Using High Performance Liquid Chromatography–Data-Dependent Acquisition–Mass Spectrometry

Molecules, 2020
Cerebrosides (Crb; including glucosylceramide and galactosylceramide) and lactosylceramide (LacCer) are structurally complex lipids found in many eukaryotic cell membranes, where they play important roles in cell growth, apoptosis, cell recognition and ...
Lin Ma, Bertram Y. Fong, Alastair K. H. MacGibbon, Gillian Norris   +3 more
doaj   +1 more source

Kidney lipids in galactosylceramide synthase-deficient mice: absence of galactosylsulfatide and compensatory increase in more polar sulfoglycolipids1

Journal of Lipid Research, 2000
UDP-galactose:ceramide galactosyltransferase (CGT) catalyzes the final step in the synthesis of galactosylceramide (GalCer). It has previously been shown that CGT-deficient mice do not synthesize GalCer and its sulfated derivative GalCer I3-sulfate ...
Keiko Tadano-Aritomi, Toshiyuki Hikita, Hirokazu Fujimoto, Kunihiko Suzuki, Kohji Motegi, Ineo Ishizuka   +5 more
doaj   +1 more source

Stereochemical structures of synthesized and natural plasmalogalactosylceramides from equine brain

Journal of Lipid Research, 1998
Modified galactosylceramide with a long-chain cyclic acetal at the sugar moiety, plasmalogalactosylceramide, was isolated from equine brain. To identify the isomeric stereostructure of the natural product, the plasmalo derivative was chemically ...
Youichi Yachida, Motoi Kashiwagi, Takeshi Mikami, Keiko Tsuchihashi, Takumi Daino, Toyoaki Akino, Shinsei Gasa   +6 more
doaj   +1 more source

FA2H-dependent fatty acid 2-hydroxylation in postnatal mouse brain

Journal of Lipid Research, 2006
2-Hydroxy fatty acids are relatively minor species of membrane lipids found almost exclusively as N-acyl chains of sphingolipids. In mammals, 2-hydroxy sphingolipids are uniquely abundant in myelin galactosylceramide and sulfatide.
Nathan L. Alderson, Eduardo N. Maldonado, Michael J. Kern, Narayan R. Bhat, Hiroko Hama   +4 more
doaj   +1 more source

Quantitative analysis of brain galactosylceramides by high performance liquid chromatography of their perbenzoyl derivatives

Journal of Lipid Research, 1976
A high performance liquid chromatographic (HPLC) method for analysis of galactosylceramides as their benzoyl derivatives has been devised. Samples containing 10-150 nmoles of monohexosylceramides are benzoylated by heating for 60 min at 60 ° C in 0.5 ml ...
E H McCluer, J E Evans
doaj   +1 more source