Results 1 to 10 of about 8,273 (177)

The PGRMC1 Antagonist AG-205 Inhibits Synthesis of Galactosylceramide and Sulfatide

Cells, 2021
Sulfatide synthesis in the human renal cancer cell line SMKT-R3 was strongly inhibited in the presence of low µM concentrations of AG-205, a progesterone receptor membrane component 1 (PGRMC1) antagonist.
Matthias Eckhardt, Lihua Wang-Eckhardt, Eckhardt Matthias   +2 more
exaly   +3 more sources

Spatial and temporal brain biodistribution of neuropathogenic sphingolipids of Krabbe disease [PDF]

Journal of Lipid Research
Glycosphingolipids are essential lipids enriched in the outer leaflet of the plasma membrane, particularly those forming the myelin sheaths. Disorders impacting the glycosphingolipid metabolism cause devastating demyelinating diseases.
Tingting Yan, Shih-Chang Hsueh, Salma Begum, Narayana Chelakkara Venkiteswaran, Justin Ellenburg, Boone M. Prentice, Gustavo H.B. Maegawa   +6 more
doaj   +2 more sources

Efficient synthesis of α-galactosylceramide and its C-6 modified analogs

Frontiers in Chemistry, 2022
The synthesis of α-galactosylceramide (KRN7000) and its C-6 modified analogs remains a challenge due to the difficult α-1,2-cis-glycosidic bond. A non-participating benzyl (Bn) protecting group has been commonly used to favor the α-glycosylation product.
Shuai Meng, Meng Shuai
exaly   +3 more sources

Probiotic treatment with viable α‐galactosylceramide‐producing Bacteroides fragilis reduces diabetes incidence in female nonobese diabetic mice [PDF]

Journal of Diabetes
Background We aimed to investigate whether alpha‐galactosylceramide (α‐GalCer)‐producing Bacteroides fragilis could induce natural killer T (NKT) cells in nonobese diabetic (NOD) mice and reduce their diabetes incidence.
Camilla H. F. Hansen, Danica Jozipovic, Line F. Zachariassen, Dennis S. Nielsen, Axel K. Hansen, Karsten Buschard   +5 more
doaj   +2 more sources

Genetic Characterization of the Acidic and Neutral Glycosphingolipid Biosynthetic Pathways in Neurospora crassa

Microorganisms, 2023
Fungal glycosphingolipids (GSLs) are important membrane components which play a key role in vesicle trafficking. To assess the importance of GSLs in the fungal life cycle, we performed a mutant phenotypic study of the acidic and neutral GSL biosynthetic ...
Jannatul F. Shoma, Ben Ernan, Griffin Keiser, Christian Heiss, Parastoo Azadi, Stephen J. Free   +5 more
doaj   +1 more source

Human Brain Lipidomics: Investigation of Formalin Fixed Brains

Frontiers in Molecular Neuroscience, 2022
Human brain lipidomics have elucidated structural lipids and lipid signal transduction pathways in neurologic diseases. Such studies have traditionally sourced tissue exclusively from brain bank biorepositories, however, limited inventories signal that ...
Aaron W. Beger, Kathleen A. Hauther, Beatrix Dudzik, Randall L. Woltjer, Randall L. Woltjer, Paul L. Wood   +5 more
doaj   +1 more source

Horse-Derived Ceramide Accentuates Glucosylceramide Synthase and Ceramide Synthase 3 by Activating PPARβ/δ and/or PPARγ to Stimulate Ceramide Synthesis

Biomedicines, 2023
Horse-derived ceramide (HC), which contains galactosylceramides as its main component, significantly improves skin symptoms when applied topically to patients with atopic dermatitis. We speculated that efficacy resulted from the amelioration of epidermal
Tami Igarashi, Hiroki Yanagi, Masayuki Yagi, Masamitsu Ichihashi, Genji Imokawa   +4 more
doaj   +1 more source

Cholesterol's interfacial interactions with galactosylceramides [PDF]

Biochemistry, 1994
Recently, the influence of acyl structure on galactosylceramide's (GalCer) interfacial phase behavior was studied [Ali, S., Smaby, J. M., & Brown, R.E. (1993) Biochemistry 32, 11696-11703]. Here, we show that acyl structure is a key parameter controlling GalCer's ability to interact with cholesterol.
S, Ali, J M, Smaby, H L, Brockman, R E, Brown   +3 more
openaire   +2 more sources

Qualitative and Quantitative Study of Glycosphingolipids in Human Milk and Bovine Milk Using High Performance Liquid Chromatography–Data-Dependent Acquisition–Mass Spectrometry

Molecules, 2020
Cerebrosides (Crb; including glucosylceramide and galactosylceramide) and lactosylceramide (LacCer) are structurally complex lipids found in many eukaryotic cell membranes, where they play important roles in cell growth, apoptosis, cell recognition and ...
Lin Ma, Bertram Y. Fong, Alastair K. H. MacGibbon, Gillian Norris   +3 more
doaj   +1 more source

Kidney lipids in galactosylceramide synthase-deficient mice: absence of galactosylsulfatide and compensatory increase in more polar sulfoglycolipids1

Journal of Lipid Research, 2000
UDP-galactose:ceramide galactosyltransferase (CGT) catalyzes the final step in the synthesis of galactosylceramide (GalCer). It has previously been shown that CGT-deficient mice do not synthesize GalCer and its sulfated derivative GalCer I3-sulfate ...
Keiko Tadano-Aritomi, Toshiyuki Hikita, Hirokazu Fujimoto, Kunihiko Suzuki, Kohji Motegi, Ineo Ishizuka   +5 more
doaj   +1 more source