Results 41 to 50 of about 8,273 (177)
Lipids in Health and Disease, 2006 Summary Background Arylsulfatase A (ASA)-deficient mice are a model for the lysosomal storage disorder metachromatic leukodystrophy. This lipidosis is characterised by the lysosomal accumulation of the sphingolipid sulfatide.
De Deyn PP +7 more
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Activation or anergy: NKT cells are stunned by -galactosylceramide [PDF]
Journal of Clinical Investigation, 2005 Invariant natural killer T (iNKT) cells are T lymphocytes that behave similarly to cells of the innate immune system. The glycolipid alpha-galactosylceramide (alpha-GalCer) is a potent and specific activator of mouse and human iNKT cells and has been used in cancer clinical trials to drive NKT cell-mediated immune responses.
Barbara A, Sullivan +1 more
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The RNA‐ and DNA‐Binding Protein Y‐Box Binding Protein 1 (YB‐1) Regulates iNKT Cell Development
European Journal of Immunology, Volume 56, Issue 5, May 2026.YB‐1 is essential for invariant NKT cell development, integrating TCR, co‐stimulatory, and IL‐15 signaling to control maturation, subset differentiation, and survival. Its loss at the double‐positive thymocyte stage causes ∼80% iNKT cell depletion, maturation arrest, impaired cytokine production, and increased apoptosis.
Silvia Schulze +7 more
wiley +1 more source
A New Possible Mechanism of Human Immunodeficiency Virus Type 1 Infection of Neural Cells
Neurobiology of Disease, 2002 To study the mechanism by which HIV-1 infects neurons we have used human neuroblastoma cell lines (NB). NB (SK-N-SH and SK-N-MC) were found to be susceptible to productive infection by X4 or R5 HIV-1, as detected by viral load and Ag-p24. To identify the
Susana Álvarez Losada +2 more
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Nonclassical MHC‐I Molecules: Emerging Therapeutic Targets in Next‐Generation Immunotherapy
MedComm, Volume 7, Issue 5, May 2026.Immunotherapies dependent on classical MHC‐I molecules face significant challenges, including extreme polymorphism and frequent downregulation in pathological conditions. This review discusses how nonclassical MHC‐I molecules (HLA‐E, HLA‐F, HLA‐G, CD1, MR1) may potentially circumvent these limitations through restricted genetic diversity, stable ...
Wanlin He, Andrew J. McMichael
wiley +1 more source
Analysis of galactosylsphingosine (psychosine) in the brain.
Journal of Lipid Research, 1984 A sensitive and specific analytical procedure has been developed for determination of galactosylsphingosine (psychosine) in the brain. The method takes advantage of two unusual properties of psychosine--the strong positive charge and the reactivity of ...
H Igisu, K Suzuki
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Galactosylceramide affects tumorigenic and metastatic properties of breast cancer cells as an anti-apoptotic molecule. [PDF]
PLoS ONE, 2013 It was recently proposed that UDP-galactose:ceramide galactosyltransferase (UGT8), enzyme responsible for synthesis of galactosylceramide (GalCer), is a significant index of tumor aggressiveness and a potential marker for the prognostic evaluation of ...
Tomasz B Owczarek +7 more
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Synthesis of Galactosylceramide and Glucosylceramide by Mouse Kidney Preparations
Journal of Biological Chemistry, 1973 A particulate fraction was prepared from kidneys, lyophilized, and coated with ceramide. After incubation with UDP-[14C]Gal and appropriate cofactors, the major radioactive component in the lipid fraction was galactosylceramide (Gal-Cer). If UDP-Glc was substituted for UDP-Gal, the product was glucosylceramide (Glc-Cer).
E, Costantino-Ceccarini, P, Morell
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Sphingomyelin Modulates the Transbilayer Distribution of Galactosylceramide in Phospholipid Membranes [PDF]
Journal of Biological Chemistry, 2002 The interrelationships among sphingolipid structure, membrane curvature, and glycosphingolipid transmembrane distribution remain poorly defined despite the emerging importance of sphingolipids in curved regions and vesicle buds of biomembranes. Here, we describe a novel approach to investigate the transmembrane distribution of galactosylceramide in ...
Peter, Mattjus +5 more
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Beyond the Barrier: Epithelial Cells as Immune Sentinels in the Female Genital Tract
American Journal of Reproductive Immunology, Volume 95, Issue 5, May 2026.ABSTRACT Epithelial cells (ECs) of the female genital tract (FGT) serve as an essential barrier and the first line of defense against sexually transmitted pathogens. Beyond providing a physical barrier, these cells actively contribute to immune responses through pathogen recognition, cytokine release, and modulation of adaptive immune responses ...
Lauren Jirik +3 more
wiley +1 more source