Results 21 to 30 of about 10,260 (172)

Serpinb1a Is Dispensable for the Development and Cytokine Response of Invariant Natural Killer T Cell Subsets

Frontiers in Immunology, 2020
Invariant natural killer T (iNKT) cells are innate-like T lymphocytes. They quickly respond to antigenic stimulation by producing copious amounts of cytokines and chemokines.
Nathan G. F. Leborgne, Nathan G. F. Leborgne, Nathan G. F. Leborgne, Adriano Taddeo, Adriano Taddeo, Stefan Freigang, Charaf Benarafa, Charaf Benarafa   +7 more
doaj   +1 more source

FA2H is responsible for the formation of 2-hydroxy galactolipids in peripheral nervous system myelins⃞

Journal of Lipid Research, 2008
Myelin in the mammalian nervous system has a high concentration of galactolipids [galactosylceramide (GalCer) and sulfatide] with 2-hydroxy fatty acids.
Eduardo N. Maldonado, Nathan L. Alderson, Paula V. Monje, Patrick M. Wood, Hiroko Hama   +4 more
doaj   +1 more source

Characterization and direct quantitation of cerebroside molecular species from lipid extracts by shotgun lipidomics

Journal of Lipid Research, 2005
By using shotgun lipidomics based on the separation of lipid classes in the electrospray ion source (intrasource separation) and two-dimensional (2D) MS techniques (Han, X., and R. W. Gross. 2004.
Xianlin Han, Hua Cheng
doaj   +1 more source

Synthesis and structure-activity relationships of cerebroside analogues as substrates of cerebroside sulphotransferase and discovery of a competitive inhibitor

Journal of Enzyme Inhibition and Medicinal Chemistry, 2020
Metachromatic leukodystrophy (MLD) is a rare genetic disease characterised by a dysfunction of the enzyme arylsulphatase A leading to the lysosomal accumulation of cerebroside sulphate (sulphatide) causing subsequent demyelination in patients. The enzyme
Wenjin Li, Joren Guillaume, Younis Baqi, Isabell Wachsmann, Volkmar Gieselmann, Serge Van Calenbergh, Christa E. Müller   +6 more
doaj   +1 more source

Presentation_1_Structure-Function Implications of the Ability of Monoclonal Antibodies Against α-Galactosylceramide-CD1d Complex to Recognize β-Mannosylceramide Presentation by CD1d.PPTX

, 2019
iNKT cells are CD1d-restricted T cells recognizing lipid antigens. The prototypic iNKT cell-agonist α-galactosylceramide (α-GalCer) alongside compounds with similar structures induces robust proliferation and cytokine production of iNKT cells and ...
Motoshi Suzuki (510968), Gavin F. Painter (215308), Jay A. Berzofsky (6694949), Masaki Terabe (370871), Katharine Clark (7478108), Jing Wang (6206297), Anja Bloom (7478114), Susanna L. Cardell (6412763), Jessica Yau (7478111), David J. Venzon (7478117), Dirk M. Zajonc (125216), Steven A. Porcelli (47915), Lise Pasquet (6884444), Benjamin J. Compton (1716781)   +13 more
core   +1 more source

Diastereomer-specific quantification of bioactive hexosylceramides from bacteria and mammals[S]

Journal of Lipid Research, 2017
Mammals synthesize, cell-type specifically, the diastereomeric hexosylceramides, β-galactosylceramide (GalCer) and β-glucosylceramide (GlcCer), which are involved in several diseases, such as sphingolipidosis, diabetes, chronic kidney diseases, or cancer.
Johanna von Gerichten, Kerstin Schlosser, Dominic Lamprecht, Ivan Morace, Matthias Eckhardt, Dagmar Wachten, Richard Jennemann, Hermann-Josef Gröne, Matthias Mack, Roger Sandhoff   +9 more
doaj   +1 more source

Targeting Sphingolipids for Cancer Therapy

Frontiers in Oncology, 2021
Sphingolipids are an extensive class of lipids with different functions in the cell, ranging from proliferation to cell death. Sphingolipids are modified in multiple cancers and are responsible for tumor proliferation, progression, and metastasis ...
Osmel Companioni, Cristina Mir, Yoelsis Garcia-Mayea, Matilde E. LLeonart, Matilde E. LLeonart   +4 more
doaj   +1 more source

Lysosomal Galactosylceramide Activity Measured by Multiple Methods.

, 2016
Galactosylceramide activity in Normal and Krabbe cells was measured using the standard MUG assay and using staining with (2) in both imaging and flow cytometry formats.
Breanna Michelle Mohr (3168264), Jason Scott Lusk (3168258), Fiona Karen Harlan (3168252), Robert Hardy Batchelor (3168261), Ying Jiang (5910), John Joseph Naleway (3168255), Anthony Peter Guzikowski (3168249)   +6 more
core   +1 more source

Author Correction: α-Galactosylceramide and its analog OCH differentially affect the pathogenesis of ISO-induced cardiac injury in mice

, 2022
This corrects the article "α-Galactosylceramide and its analog OCH differentially affect the pathogenesis of ISO-induced cardiac injury in mice" in volume 41 on page ...
Liu, Jie, Lai, Wen-jing, Yang, Sheng-qian, Chen, Xin, Wang, Wen-jia, Liu, Ying, Cao, Da-yan, Deng, Ya-fei, Li, Xiao-hui, Shou, Wei-nian, Zhou, Jian-zhi, Li, Shu-hui   +11 more
core   +1 more source

Krabbe disease: a galactosylsphingosine (psychosine) lipidosis.

Journal of Lipid Research, 1980
The primary genetic defect underlying Krabbe disease or globoid cell leukodystrophy is considered to be a deficiency of galactosylceramide-beta-galactosidase.
L Svennerholm, M T Vanier, J E Månsson
doaj   +1 more source