Results 21 to 30 of about 8,273 (177)

Serpinb1a Is Dispensable for the Development and Cytokine Response of Invariant Natural Killer T Cell Subsets

Frontiers in Immunology, 2020
Invariant natural killer T (iNKT) cells are innate-like T lymphocytes. They quickly respond to antigenic stimulation by producing copious amounts of cytokines and chemokines.
Nathan G. F. Leborgne, Nathan G. F. Leborgne, Nathan G. F. Leborgne, Adriano Taddeo, Adriano Taddeo, Stefan Freigang, Charaf Benarafa, Charaf Benarafa   +7 more
doaj   +1 more source

Proliferation and Directional Differentiation of iNKT Cells Derived from DBA/1 Mice Thymus

Iranian Journal of Allergy, Asthma and Immunology, 2021
The rates of invariant natural killer T (iNKT) cells in vivo are very low, and the amounts of cells obtained directly from the body are hard enough to fulfill their potential in clinical application.
Dongzhi Chen, Zhao Li, Rui Liang, Huifang Liu, Yuanyuan Wang, Hongyun Shi, Ming Meng   +6 more
doaj   +1 more source

FA2H is responsible for the formation of 2-hydroxy galactolipids in peripheral nervous system myelins⃞

Journal of Lipid Research, 2008
Myelin in the mammalian nervous system has a high concentration of galactolipids [galactosylceramide (GalCer) and sulfatide] with 2-hydroxy fatty acids.
Eduardo N. Maldonado, Nathan L. Alderson, Paula V. Monje, Patrick M. Wood, Hiroko Hama   +4 more
doaj   +1 more source

Sex differences in gene expression with galactosylceramide treatment in Cln3Δex7/8 mice

PLoS ONE, 2020
Background CLN3 disease is caused by mutations in the CLN3 gene. The purpose of this study is to discern global expression patterns reflecting therapeutic targets in CLN3 disease.
Joelle Makoukji, Sally El-Sitt, Nadine J. Makhoul, Jihane Soueid, Humam Kadara, Rose-Mary Boustany, Francisco J. Esteban   +6 more
doaj   +2 more sources

Characterization and direct quantitation of cerebroside molecular species from lipid extracts by shotgun lipidomics

Journal of Lipid Research, 2005
By using shotgun lipidomics based on the separation of lipid classes in the electrospray ion source (intrasource separation) and two-dimensional (2D) MS techniques (Han, X., and R. W. Gross. 2004.
Xianlin Han, Hua Cheng
doaj   +1 more source

Synthesis and structure-activity relationships of cerebroside analogues as substrates of cerebroside sulphotransferase and discovery of a competitive inhibitor

Journal of Enzyme Inhibition and Medicinal Chemistry, 2020
Metachromatic leukodystrophy (MLD) is a rare genetic disease characterised by a dysfunction of the enzyme arylsulphatase A leading to the lysosomal accumulation of cerebroside sulphate (sulphatide) causing subsequent demyelination in patients. The enzyme
Wenjin Li, Joren Guillaume, Younis Baqi, Isabell Wachsmann, Volkmar Gieselmann, Serge Van Calenbergh, Christa E. Müller   +6 more
doaj   +1 more source

Diastereomer-specific quantification of bioactive hexosylceramides from bacteria and mammals[S]

Journal of Lipid Research, 2017
Mammals synthesize, cell-type specifically, the diastereomeric hexosylceramides, β-galactosylceramide (GalCer) and β-glucosylceramide (GlcCer), which are involved in several diseases, such as sphingolipidosis, diabetes, chronic kidney diseases, or cancer.
Johanna von Gerichten, Kerstin Schlosser, Dominic Lamprecht, Ivan Morace, Matthias Eckhardt, Dagmar Wachten, Richard Jennemann, Hermann-Josef Gröne, Matthias Mack, Roger Sandhoff   +9 more
doaj   +1 more source

Quantification and Localisation of New Brain Lipid Synthesis Using Deuterium Oxide and High Resolution Mass Spectrometry

Angewandte Chemie, Volume 138, Issue 18, 27 April 2026.
Liquid chromatography tandem mass spectrometry and mass spectrometry imaging were used in combination with deuterium oxide administration to quantify and localise newly synthesised myelin lipids in the mouse brain. This methodology, used here to show sites of myelin repair, enables the measurement of dynamic lipid synthesis in living systems and ...
Catherine Zhang, Jesse A. Michael, Jonathan D. Teo, Huitong Song, Mika T. Westerhausen, Shadrack M. Mutuku, Shane R. Ellis, Anthony S. Don   +7 more
wiley   +2 more sources

Krabbe disease: a galactosylsphingosine (psychosine) lipidosis.

Journal of Lipid Research, 1980
The primary genetic defect underlying Krabbe disease or globoid cell leukodystrophy is considered to be a deficiency of galactosylceramide-beta-galactosidase.
L Svennerholm, M T Vanier, J E Månsson
doaj   +1 more source

Targeting Sphingolipids for Cancer Therapy

Frontiers in Oncology, 2021
Sphingolipids are an extensive class of lipids with different functions in the cell, ranging from proliferation to cell death. Sphingolipids are modified in multiple cancers and are responsible for tumor proliferation, progression, and metastasis ...
Osmel Companioni, Cristina Mir, Yoelsis Garcia-Mayea, Matilde E. LLeonart, Matilde E. LLeonart   +4 more
doaj   +1 more source