Results 11 to 20 of about 10,260 (172)

Time-course analysis of liver and serum galectin-3 in acute liver injury after alpha-galactosylceramide injection.

PLoS ONE
Galectin-3 is a beta-galactoside-binding lectin that plays important roles in diverse physiological functions, such as cell proliferation, apoptosis, and mRNA splicing.
Mikiko Matsuo, Ayumu Kanbe, Kei Noguchi, Ayumi Niwa, Yuko Imaizumi, Takahito Kuroda, Koki Ichihashi, Takafumi Okubo, Kosuke Mori, Tomohiro Kanayama, Hiroyuki Tomita, Akira Hara   +11 more
doaj   +2 more sources

Unraveling A4GALT Mechanism and Its Modulation With Adamantyl-Galactosylceramide Analogues: Advancing Fabry Disease Therapeutic Strategies. [PDF]

Angew Chem Int Ed Engl
A 310‐helix‐mediated conformational switch promotes a front‐face SNi‐like catalysis by human A4GALT. Mechanism‐guided design identifies AdaGalCer as a selective modulator of globotriaosylceramide (Gb3) biosynthesis, opening a clear route toward new Fabry disease therapeutics.
de Koster N, Vidal-Gironès Ò, de Graaf R, Kok K, Lelieveld LT, Hoogervorst J, Ferraz MJ, Rivas-Fernández JP, Lammers RF, Overkleeft HS, Aerts JMFG, Boot RG, Rovira C, Artola M.   +13 more
europepmc   +3 more sources

Hydroxylated (OH) galactosylceramide and glucosylceramide species in iPSC-derived astrocytes.

, 2022
(A) Hydroxylated galactosylceramide was higher in Krabbe astrocytes compared to controls. Examination of the species of OH-galactosylceramide expressed in our cell cultured revealed this increase was driven by C16 OH-galactosylceramide.
Hyejung Park (1322841), Patrick L. Jones (13194701), R. Bridge Hunter (13194704), Richard Lieberman (13194698), Leslie K. Cortes (7377488), Bing Wang (126120), Robert H. Barker Jr. (13194707), John P. Leonard (8755311), Grace Gao (7066793)   +8 more
core   +1 more source

Non-hydroxylated galactosylceramide and glucosylceramide species in iPSC-derived astrocytes.

, 2022
(A) The profile of non-hydroxylated galactosylceramide species in control and Krabbe astrocytes suggests that shorter carbon chain length species are the predominant isoforms.
Hyejung Park (1322841), Patrick L. Jones (13194701), R. Bridge Hunter (13194704), Richard Lieberman (13194698), Leslie K. Cortes (7377488), Bing Wang (126120), Robert H. Barker Jr. (13194707), John P. Leonard (8755311), Grace Gao (7066793)   +8 more
core   +1 more source

Quantifying Beta‐Galactosylceramide Kinetics in Cerebrospinal Fluid of Healthy Subjects Using Deuterium Labeling [PDF]

, 2016
Therapeutics promoting myelin synthesis may enhance recovery in demyelinating diseases, such as multiple sclerosis. However, no suitable method exists to quantify myelination.
Goulooze, S.C., Dent, G., Cohen, A.F., Hankemeier, T., Hay, J.L., Meijering, H., Groeneveld, G.J., Stevens, J., Chavez, J.C., Kanhai, K.M.S., Verma, A., Boer, T. de   +11 more
core   +1 more source

Reduced chain length in myelin sphingolipids and poorer motor coordination in mice deficient in the fatty acid elongase Elovl1

FASEB BioAdvances, 2019
Very‐long‐chain fatty acids, with a chain length of >C20, are abundant in myelin sphingolipids. Recently, a de novo mutation in the ELOVL1 gene, which encodes fatty acid elongase, was identified in patients with neurocutaneous disorders involving skin ...
Masashi Isokawa, Takayuki Sassa, Satoko Hattori, Tsuyoshi Miyakawa, Akio Kihara   +4 more
doaj   +1 more source

Neutral glycosphingolipids in human blood: a precise mass spectrometry analysis with special reference to lipoprotein-associated Shiga toxin receptors[S]

Journal of Lipid Research, 2010
Shiga toxin (Stx)-producing Escherichia coli are the leading cause of hemorrhagic colitis and life-threatening extraintestinal complications in humans. Stx1 and Stx2 are transferred by yet to be delineated mechanisms from the intestine to the circulation
Christian H. Schweppe, Petra Hoffmann, Jerzy-Roch Nofer, Gottfried Pohlentz, Michael Mormann, Helge Karch, Alexander W. Friedrich, Johannes Müthing   +7 more
doaj   +1 more source

Functional invariant natural killer T-cell and CD1d axis in chronic lymphocytic leukemia: implications for immunotherapy

Haematologica, 2013
Invariant natural killer T cells recognize glycolipid antigens such as α-galactosylceramide presented by CD1d. In preclinical models of B-cell malignancies, α-galactosylceramide is an adjuvant to tumor vaccination, enhancing tumor-specific T-cell ...
Robert Weinkove, Collin R. Brooks, John M. Carter, Ian F. Hermans, Franca Ronchese   +4 more
doaj   +1 more source

Simultaneous quantification of lyso-neutral glycosphingolipids and neutral glycosphingolipids by N-acetylation with [3H]acetic anhydride

Journal of Lipid Research, 2003
We describe a new method that permits quantification in the pmol to nmol range of three lyso-neutral glycosphingolipids (lyso-n-GSLs), glucosylsphingosine (GlcSph), galactosylsphingosine (GalSph), and lactosylsphingosine, in the same sample as neutral ...
Jacques Bodennec, Selena Trajkovic-Bodennec, Anthony H. Futerman   +2 more
doaj   +1 more source

Proliferation and Directional Differentiation of iNKT Cells Derived from DBA/1 Mice Thymus

Iranian Journal of Allergy, Asthma and Immunology, 2021
The rates of invariant natural killer T (iNKT) cells in vivo are very low, and the amounts of cells obtained directly from the body are hard enough to fulfill their potential in clinical application.
Dongzhi Chen, Zhao Li, Rui Liang, Huifang Liu, Yuanyuan Wang, Hongyun Shi, Ming Meng   +6 more
doaj   +1 more source