Results 51 to 60 of about 8,273 (177)

Preparative scale isolation of sphingosine.

Journal of Lipid Research, 1990
A high-yield method is described for the preparation of sphingenine from galactosylceramide. Two successive cleavage reactions are used, alkaline butanol to form galactosylsphingosine, then acidic acetonitrile to form the sphingenine.
NS Radin
doaj   +1 more source

IFN-γ-STAT1-ERK Pathway Mediates Protective Effects of Invariant Natural Killer T Cells Against Doxorubicin-Induced Cardiomyocyte Death

JACC: Basic to Translational Science, 2023
Summary: Doxorubicin (DOX)-induced cardiomyopathy has poor prognosis, and myocardial inflammation is intimately involved in its pathophysiology. The role of invariant natural killer T (iNKT) cells has not been fully determined in this disease.
Masashi Sada, MD, Shouji Matsushima, MD, PhD, Masataka Ikeda, MD, PhD, Soichiro Ikeda, MD, PhD, Kosuke Okabe, MD, PhD, Akihito Ishikita, MD, PhD, Tomonori Tadokoro, MD, PhD, Nobuyuki Enzan, MD, PhD, Taishi Yamamoto, MD, Hiroko Deguchi Miyamoto, MD, PhD, Yoshitomo Tsutsui, MD, Ryo Miyake, MD, Daiki Setoyama, PhD, Dongchon Kang, MD, PhD, Tomomi Ide, MD, PhD, Hiroyuki Tsutsui, MD, PhD   +15 more
doaj   +1 more source

Mixed Signals: T Cells as Architects of IgE Immunity

Immunological Reviews, Volume 339, Issue 1, May 2026.
ABSTRACT Food allergen‐specific IgE can cause significant pathology, yet the pathways that generate pathogenic, high‐affinity IgE remain incompletely understood. Increasing evidence suggests that IgE responses arise from the integration of multiple, and sometimes opposing, T cell–derived cues.
Abigail L. Tierney, Wallace P. Bezerra, Stephanie C. Eisenbarth, Adam Williams   +3 more
wiley   +1 more source

Abnormalities of glycosphingolipids in mucopolysaccharidosis type III B.

Journal of Lipid Research, 1984
Glycosphingolipids from brain, liver, and spleen of a patient with mucopolysaccharidosis type III B were quantitatively analyzed. Neutral glycosphingolipids containing glucosylceramide, lactosylceramide, globotriaosylceramide, globotetraosylceramide, and
A Hara, N Kitazawa, T Taketomi
doaj   +1 more source

Suppression of eosinophilic airway inflammation by treatment with α‐galactosylceramide [PDF]

European Journal of Immunology, 2005
AbstractTo clarify the essential role of NKT cells in allergy, we investigated the contribution of NKT cells to the pathogenesis of eosinophilic airway inflammation using α‐galactosylceramide (α‐GalCer), a selective ligand for NKT cells. Although continuous administration of α‐GalCer during ovalbumin (OVA) sensitization increased OVA‐specific IgE ...
Yuko, Morishima, Yukio, Ishii, Toru, Kimura, Akira, Shibuya, Kazuko, Shibuya, Ahmed E, Hegab, Takashi, Iizuka, Takumi, Kiwamoto, Yosuke, Matsuno, Tohru, Sakamoto, Akihiro, Nomura, Masaru, Taniguchi, Kiyohisa, Sekizawa   +12 more
openaire   +2 more sources

Reduced plasma hexosylceramides in frontotemporal dementia are a biomarker of white matter integrity

Alzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring
INTRODUCTION Blood biomarkers are needed to facilitate new therapeutic trials and improve management of behavioral variant frontotemporal dementia (bvFTD).
Oana C. Marian, Sophie Matis, Carol Dobson‐Stone, Woojin S. Kim, John B. Kwok, Olivier Piguet, Glenda M. Halliday, Ramon Landin‐Romero, Anthony S. Don   +8 more
doaj   +1 more source

Integrated Analysis of Gut Microbiota and Metabolome Profiling Reveals the Effects of Feeding Approaches on Infants' Gut Microenvironment

Food Science &Nutrition, Volume 14, Issue 4, April 2026.
This graphical abstract illustrates the gut microenvironment disparities between breastfed and formula‐fed infants at 6 months of age. Through multi‐omics analysis, breastfeeding was shown to establish a distinct ecological imprinting characterized by favorable microbial shifts and down‐regulated pro‐inflammatory arachidonic acid metabolism, thereby ...
Simin Zhu, Wenjuan Tu, Wenting Zhang, Li Qing, Chengan Wang   +4 more
wiley   +1 more source

Leishmania Extracellular Vesicles as a Preventive Vaccine Platform Against Leishmaniasis

Journal of Extracellular Vesicles, Volume 15, Issue 4, April 2026.
The potential of Leishmania‐derived extracellular vesicles (EVs) as a vaccine platform was investigated, emphasizing an affordable, GMP‐compliant production and purification method. Immunization with EV vaccines, either unadjuvanted or combined with α‐galactosylceramide (αGC), induced robust humoral and cellular immune responses, conferring protection ...
Ismail Cem Yilmaz, Ibrahim Tokmak, Muzaffer Yildirim, Tugce Canavar Yildirim, Elif Sena Ozkoc, Irem Evcili, Emre Mert Ipekoglu, İhsan Cihan Ayanoglu, Emre Dunuroglu, Dicle Caliskan, Harun Onler, Zeynep Arzum, Ceren Ulker, Olcay Mert, Ridvan Orkut, Ibrahim Oguzhan Tarman, Ulku Guler, Bekir Salih, Volkan Yazar, Gokcen Ozgun, Serap Birincioglu, Ahmet Ozbilgin, Bilgi Gungor, Ihsan Gursel, Mayda Gursel   +24 more
wiley   +1 more source

Heparan Sulfate Proteoglycans in Immunity

Proteoglycan Research, Volume 4, Issue 2, April 2026.
ABSTRACT In immune cells, heparin was first identified in mast cells in the 1940s, followed by the discovery of heparan sulfate in lymphocytes and granulocytes during the 1970s and 1980s. Subsequent decades of research have revealed how heparan sulfate and heparin, conjugated to core proteins as heparan sulfate proteoglycans (HSPGs), act as versatile ...
Moe Iwai, Pyong Woo Park
wiley   +1 more source

Biological Roles Played by Sphingolipids in Dimorphic and Filamentous Fungi

mBio, 2018
Filamentous and dimorphic fungi cause invasive mycoses associated with high mortality rates. Among the fungal determinants involved in the establishment of infection, glycosphingolipids (GSLs) have gained increased interest in the last few decades.
Caroline Mota Fernandes, Gustavo H. Goldman, Maurizio Del Poeta   +2 more
doaj   +1 more source