Results 51 to 60 of about 10,260 (172)

Galactosylceramide affects tumorigenic and metastatic properties of breast cancer cells as an anti-apoptotic molecule. [PDF]

PLoS ONE, 2013
It was recently proposed that UDP-galactose:ceramide galactosyltransferase (UGT8), enzyme responsible for synthesis of galactosylceramide (GalCer), is a significant index of tumor aggressiveness and a potential marker for the prognostic evaluation of ...
Tomasz B Owczarek, Jarosław Suchanski, Bartosz Pula, Alicja M Kmiecik, Marek Chadalski, Aleksandra Jethon, Piotr Dziegiel, Maciej Ugorski   +7 more
doaj   +1 more source

Cancer Vaccine Development: Toward Artificial Intelligence‐Assisted Personalized Cell Membrane Nanovaccine

Small, Volume 22, Issue 49, 1 September 2026.
Cancer nanovaccines have emerged as promising alternatives to conventional cancer vaccines, which have shown limited clinical efficacy. In particular, cell membrane nanoparticle‐based nanovaccines can offer high biocompatibility and immunogenicity while preserving tumor antigens, including antigen repertoires.
Munsik Kim, Ilkoo Noh
wiley   +1 more source

The crystal structure of human CD1d with and without ?-galactosylceramide

, 2005
The glycolipid ?-galactosylceramide binds with high affinity to CD1d and stimulates natural killer T cells. Here we report the crystal structure of human CD1d in complex with synthetic ?-galactosylceramide at a resolution of 3.0 Å.
Ritter, G, Victoria S Stronge, Richard R Schmidt, Gadola, Stephan D., Besra, Gurdyal; id_orcid, Stronge, Victoria S., Besra, Gurdyal S., Jones, E. Yvonne, E Yvonne Jones, Bini Mathew, Mathew, B, Mathew, Bini, Schmidt, Richard R., Koch, M, Cerundolo, Vincenzo, Stephan D Gadola, Cerundolo, V, Schmidt, RR, Gurdyal S Besra, Stronge, VS, Koch, Michael, Besra, GS, Jones, EY, Fersht, AR, Shephard, D, Michael Koch, Fersht, Alan R., Vincenzo Cerundolo, Jones, Edith, Gadola, SD, Shepherd, D, Alan R Fersht, Ritter, Gerd, Dawn Shepherd, Shepherd, Dawn, Gerd Ritter   +35 more
core   +1 more source

Preparative scale isolation of sphingosine.

Journal of Lipid Research, 1990
A high-yield method is described for the preparation of sphingenine from galactosylceramide. Two successive cleavage reactions are used, alkaline butanol to form galactosylsphingosine, then acidic acetonitrile to form the sphingenine.
NS Radin
doaj   +1 more source

IFN-γ-STAT1-ERK Pathway Mediates Protective Effects of Invariant Natural Killer T Cells Against Doxorubicin-Induced Cardiomyocyte Death

JACC: Basic to Translational Science, 2023
Summary: Doxorubicin (DOX)-induced cardiomyopathy has poor prognosis, and myocardial inflammation is intimately involved in its pathophysiology. The role of invariant natural killer T (iNKT) cells has not been fully determined in this disease.
Masashi Sada, MD, Shouji Matsushima, MD, PhD, Masataka Ikeda, MD, PhD, Soichiro Ikeda, MD, PhD, Kosuke Okabe, MD, PhD, Akihito Ishikita, MD, PhD, Tomonori Tadokoro, MD, PhD, Nobuyuki Enzan, MD, PhD, Taishi Yamamoto, MD, Hiroko Deguchi Miyamoto, MD, PhD, Yoshitomo Tsutsui, MD, Ryo Miyake, MD, Daiki Setoyama, PhD, Dongchon Kang, MD, PhD, Tomomi Ide, MD, PhD, Hiroyuki Tsutsui, MD, PhD   +15 more
doaj   +1 more source

The RNA‐ and DNA‐Binding Protein Y‐Box Binding Protein 1 (YB‐1) Regulates iNKT Cell Development

European Journal of Immunology, Volume 56, Issue 5, May 2026.
YB‐1 is essential for invariant NKT cell development, integrating TCR, co‐stimulatory, and IL‐15 signaling to control maturation, subset differentiation, and survival. Its loss at the double‐positive thymocyte stage causes ∼80% iNKT cell depletion, maturation arrest, impaired cytokine production, and increased apoptosis.
Silvia Schulze, Laura Knop, Nouria Jantz‐Naeem, Vladyslava Dovhan, Stephan Fricke, Sascha Kahlfuß, Thomas Schüler, Ursula Bommhardt   +7 more
wiley   +1 more source

V3 loop-derived peptide SPC3 inhibits infection of CD4- and galactosylceramide- cells by LAV-2/B

, 1999
SPC3, a synthetic multibranched peptide including the GPGRAF consensus motif of the human immunodeficiency virus type 1 (HIV-1) gp120 V3-loop is a potent inhibitor of HIV infection of human CD4 + lymphocytes, macrophages and CD4 -/galactosylceramide ...
Rochat, Hervé, Van Rietschoten, Jurphaas, Mabrouk, Kamel, Moulard, Maxime, Martin, Isabelle, Sabatier, Jean Marc   +5 more
core   +1 more source

Abnormalities of glycosphingolipids in mucopolysaccharidosis type III B.

Journal of Lipid Research, 1984
Glycosphingolipids from brain, liver, and spleen of a patient with mucopolysaccharidosis type III B were quantitatively analyzed. Neutral glycosphingolipids containing glucosylceramide, lactosylceramide, globotriaosylceramide, globotetraosylceramide, and
A Hara, N Kitazawa, T Taketomi
doaj   +1 more source

Nonclassical MHC‐I Molecules: Emerging Therapeutic Targets in Next‐Generation Immunotherapy

MedComm, Volume 7, Issue 5, May 2026.
Immunotherapies dependent on classical MHC‐I molecules face significant challenges, including extreme polymorphism and frequent downregulation in pathological conditions. This review discusses how nonclassical MHC‐I molecules (HLA‐E, HLA‐F, HLA‐G, CD1, MR1) may potentially circumvent these limitations through restricted genetic diversity, stable ...
Wanlin He, Andrew J. McMichael
wiley   +1 more source

Reduced plasma hexosylceramides in frontotemporal dementia are a biomarker of white matter integrity

Alzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring
INTRODUCTION Blood biomarkers are needed to facilitate new therapeutic trials and improve management of behavioral variant frontotemporal dementia (bvFTD).
Oana C. Marian, Sophie Matis, Carol Dobson‐Stone, Woojin S. Kim, John B. Kwok, Olivier Piguet, Glenda M. Halliday, Ramon Landin‐Romero, Anthony S. Don   +8 more
doaj   +1 more source