Results 71 to 80 of about 10,260 (172)

Cord blood Vα24-Vβ11 natural killer T cells display a Th2-chemokine receptor profile and cytokine responses [PDF]

, 2011
Background: The fetal immune system is characterized by a Th2 bias but it is unclear how the Th2 predominance is established. Natural killer T (NKT) cells are a rare subset of T cells with immune regulatory functions and are already activated in utero ...
Elfriede Noessner, Krauss-Etschmann, S., Faber Fabienne L., Harner, Susanne, Harner, S., Nadas, Korinna, Leumann-Runge Anke, Leumann-Runge, A., Leumann-Runge, Anke, Susanne Harner, Korinna Nadas, Nadas, K., Joachim Heinrich, Heinrich, Joachim, Fabienne L Faber, Nadas Korinna, Heinrich, J., Noessner Elfriede, Noessner, Elfriede, Anke Leumann-Runge, Schiemann, Matthias, Susanne Krauss-Etschmann, Krauss-Etschmann Susanne, Fabienne L. Faber, Schiemann Matthias, Nößner, E., Faber, Fabienne L., Krauss-Etschmann, Susanne, Schiemann, M., Faber, F.L., Heinrich Joachim, Harner Susanne, Matthias Schiemann, Harner, S;Noessner, E;Nadas, K;Leumann-Runge, A;Schiemann, M;Faber, FL;Heinrich, J;Krauss-Etschmann, S   +33 more
core   +2 more sources

Development of a Self‐Adjuvanting Influenza Peptide–Glycolipid Conjugate Inducing CD8+ T‐Cell Immunity

ChemBioChem, Volume 27, Issue 5, 13 March 2026.
The glycolipid‐peptide antigen complexes for self‐adjuvanting conjugates were successfully synthesized, and, with the HLA‐transgenic mice, the antigen‐specific CD8+ T cell expansion was exhibited. The results provide useful insights for the design and synthesis of vaccine conjugates using glycolipid antigen as an adjuvant.
Shunya Kikuchi, Hideki Ogura, Takanori Matsumaru, Satoshi Ishido, Yukari Fujimoto   +4 more
wiley   +1 more source

Programmable Antigen‐Specific Immunity via Self‐Adjuvanting Nanovaccines Co‐Delivering Immune Modulators

Angewandte Chemie, Volume 138, Issue 11, 9 March 2026.
The self‐adjuvanting vaccine—comprising a covalent conjugate of antigen and adjuvant—was formulated into cationic lipid nanoparticles smaller than 100 nm to facilitate uptake by immune cells, with supplemental adjuvants incorporated to modulate immune responses.
Keita Ito, Yoshiyuki Manabe, Shino Ohshima, Masatoshi Maeki, Manabu Tokeshi, Hiroshi Inaba, Kazunori Matsuura, Kazuya Kabayama, Yoshie Kametani, Koichi Fukase   +9 more
wiley   +1 more source

Molecular features of phospholipids that affect glycolipid transfer protein-mediated galactosylceramide transfer between vesicles [PDF]

, 2006
The glycolipid transfer protein (GLTP)-mediated movement of galactosylceramide from model membrane donor vesicles to acceptor vesicles is sensitive to the membrane environment surrounding the glycolipid.
Byun, Hoe-Sup, Molotkovsky, Julian G., Mattjus, Peter, Nylund, Matts, Kjellberg, Matti A., Bittman, Robert   +5 more
core   +1 more source

Synthesis of NBD-α-galactosylceramide and Its Immunologic Properties

, 2016
A representative α-galactosylceramide (α-GalCer), KRN7000, can activate NKT cells through CD1d molecules, which play an essential role in the generation of the strong antitumor activity of KRN7000.
Teruyuki Sakai (2435098), Yasuhiko Koezuka (3075336), Hiromi Ehara (3075333)   +2 more
core   +1 more source

alpha-Galactosylceramide protects swine against influenza infection when administered as a vaccine adjuvant [PDF]

, 2016
Citation: Artiaga, B. L., Yang, G., Hackmann, T. J., Liu, Q. F., Richt, J. A., Salek-Ardakani, S., . . . Driver, J. P. (2016). alpha-Galactosylceramide protects swine against influenza infection when administered as a vaccine adjuvant. Scientific Reports,
Yang, Guan, Artiaga, B. L., Yang, G., Hackmann, T. J., Castleman, W. L., Artiaga, Bianca L, Salek-Ardakani, S., Hackmann, Timothy J, Salek-Ardakani, Shahram, Driver, J. P., Richt, Juergen A., Lednicky, J. A., Castleman, William L, Liu, Qinfang, Richt, Jürgen A, Driver, John P, Lednicky, John A, Liu, Q. F.   +17 more
core   +1 more source

DataSheet1_Efficient synthesis of α-galactosylceramide and its C-6 modified analogs.docx

, 2022
The synthesis of α-galactosylceramide (KRN7000) and its C-6 modified analogs remains a challenge due to the difficult α-1,2-cis-glycosidic bond. A non-participating benzyl (Bn) protecting group has been commonly used to favor the α-glycosylation product.
Shuai Meng (589281), Chengli Zong (1349238), Huiting Li (791954), Hongzhao Mao (14173020), Ying Xu (9172), Chao Chen (195669), Tiantian Sun (154175)   +6 more
core   +1 more source

3-O-acetyl-sphingosine-series myelin glycolipids

Journal of Lipid Research, 2002
Several glycosphingolipids, less polar than galactosylceramide (GalCer), have been purified from rat brain and designated as fast migrating cerebrosides (FMCs). They co-appear with GalCer during myelinogenesis, reach a peak concentration at postnatal day
Somsankar Dasgupta, Steven B. Levery, Edward L. Hogan   +2 more
doaj   +1 more source

Expedient Synthesis of the Alpha-C-Glycoside Analogue of the Immunostimulant Galactosylceramide (KRN7000).

, 2006
[Structure: see text] Key reactions in a concise synthesis of an alpha-C-galactosylceramide analogue of KRN7000 include a diastereoselective alkenylalane addition to an N-tert-butanesulfinyl imine and the use of an epoxidation/carbamate ring opening ...
Wipf, Peter, Pierce, Joshua G
core   +1 more source

Domain Nucleation Rates and Interfacial Line Tensions in Supported Bilayers of Ternary Mixtures Containing Galactosylceramide [PDF]

, 2008
Domains within the plane of the plasma membrane, referred to as membrane rafts, have been a topic of considerable interest in the field of membrane biophysics. Although model membrane systems have been used extensively to study lipid phase behavior as it
Longo, Marjorie L., Ratto, Timothy V., Blanchette, Craig D., Lin, Wan-Chen, Orme, Christine A.   +4 more
core   +1 more source