Results 81 to 90 of about 10,260 (172)

Versatile synthesis of phenoxydiazirine-based fatty acid analogues and photoreactive galactosylceramide [PDF]

application/pdfA versatile synthesis of diazirine-based photoreactive fatty acid analogues is reported. The key step is phenoxy alkylation of diazirine with halo alkyl acid esters.
Hashimoto, Makoto, 橋本, 誠, Nabeta, Kensuke, Hatanaka, Yasumaru   +3 more
core   +1 more source

Dual modifications of alpha-galactosylceramide synergize to promote activation of human invariant natural killer T cells and stimulate anti-tumor immunity [PDF]

, 2018
Glycosylceramides that activate CD1d-restricted invariant natural killer T (iNKT) cells have potential therapeutic applications for augmenting immune responses against cancer and infections.
Wen, Xiangshu, Carreño, LJ, Godfrey, DI, Chennamadhavuni, Divya, Pryce, R, Steven A. Porcelli, Saavedra-Avila, NA, Srinivasan Sundararaj, Godfrey, Dale I., Xiangshu Wen, Jérôme Le Nours, Wen, X, Le Nours, Jérôme, Le Nours, J, Gascón, JA, Yongqing, Tang, Chennamadhavuni, D, Keshipeddy, S, Jamie Rossjohn, Weiming Yuan, Pooja Arora, Howell, Amy R., Carreño, Leandro J., Porcelli, Steven A., Koay, H-F, Pryce, Rhys, Koay, Hui Fern, Divya Chennamadhavuni, Lo, JH, Rossjohn, Jamie, Arora, Pooja, Richardson, SK, Yuan, Weiming, Howell, AR, Santosh Keshipeddy, Jae Ho Lo, Richardson, Stewart K., Arora, P, Porcelli, SA, Le Nours, Jéroˆme, Tang Yongqing, Yongqing, T, Leandro J. Carreño, Matthew J. Guberman-Pfeffer, Stewart K. Richardson, Guberman-Pfeffer, Matthew J., Guberman-Pfeffer, MJ, Saavedra-Avila, Noemi Alejandra, Amy R. Howell, José A. Gascón, Dale I. Godfrey, Sundararaj, S, Hui-Fern Koay, Yuan, W, Rossjohn, J, Koay, Hui-Fern, Gascón, José A., Carreño Marquez, Leandro J., Yongqing, Tan, Rhys Pryce, Lo, Jae Ho, Sundararaj, Srinivasan, Noemi Alejandra Saavedra-Avila, Keshipeddy, Santosh   +63 more
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Paucity of CD4+ natural killer T (NKT) lymphocytes in sooty mangabeys is associated with lack of NKT cell depletion after SIV infection.

PLoS ONE, 2010
Lack of chronic immune activation in the presence of persistent viremia is a key feature that distinguishes nonpathogenic simian immunodeficiency virus (SIV) infection in natural hosts from pathogenic SIV and HIV infection.
Namita Rout, James G Else, Simon Yue, Michelle Connole, Mark A Exley, Mark A Exley, Amitinder Kaur   +6 more
doaj   +1 more source

Clinical experience with α-galactosylceramide (KRN7000) in patients with advanced cancer and chronic hepatitis B/C infection.

, 2011
For over a century, research has sought ways to boost the immune system in order to eradicate tumors and viruses that exist after escaping immunosurveillance. For the treatment of cancer and hepatitis immunotherapeutic strategies have overall had limited
Verheul, H.M.W., Woltman, Andrea, B. Mary E. von Blomberg, Verheul, HMW, Rik J. Scheper, Schneiders, F.L., von Blomberg, B.M.E., van den Eertwegh, A.J.M., Hans J. van der Vliet, Scheper, R.J., von Blomberg, BME, Schneiders, FL, van den Eertwegh, AJM (Fons), Famke L. Schneiders, Scheper, RJ, van der Vliet, J.J., Harry L.A. Janssen, de Gruijl, T.D., Henk M.W. Verheul, Janssen, HLA, Tanja D. de Gruijl, Woltman, A.M., de Gruijl, TD, Janssen, H.L.A., van der Vliet, HJ, Andrea M. Woltman, Alfons J.M. van den Eertwegh   +26 more
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The bovine CD1D gene has an unusual gene structure and is expressed but cannot present α-galactosylceramide with a C26 fatty acid [PDF]

, 2012
Although CD1d and NKT cells have been proposed to have highly conserved functions in mammals, data on functions of CD1d and NKT cells in species other than humans and rodents are lacking.
Dep Infectieziekten Immunologie, Jervis, PJ, Koets, Ad P, Dirk M. Zajonc, Peter J. Jervis, Thi, Kim Anh Nguyen, Serge van Calenbergh, Moody, D Branch, Thi, KAN, Koets, AP, Zajonc, Dirk M, Cox, Liam R; id_orcid, Van Rhijn, Ildiko, Graham, SP, Besra, GS, Santema, W.J., Nguyen, Thi Kim Anh, Cox, L.R., Besra, Gurdyal S; id_orcid, Strategic Infection Biology, Thi Kim Anh Nguyen, Wiebren J. Santema, Besra, G.S., Cox, Liam R, Cox, LR, van Calenbergh, S, Besra, Gurdyal S, Santema, Wiebren J, Liam R. Cox, Moody, D.B., Martin Vordermeier, Jervis, Peter J, van Calenbergh, S., Simon P. Graham, Vordermeier, M, D. Branch Moody, Vordermeier, M., Zajonc, D.M., Van Calenbergh, Serge, Van Rhijn, I, Gurdyal S. Besra, Moody, DB, Jervis, P.J., Santema, WJ, Ad P. Koets, Vordermeier, Martin, Ildiko Van Rhijn, van Rhijn, I., Dep Gezondheidszorg Landbouwhuisdieren, Zajonc, DM, Nguyen, T.K.A., Koets, A.P., Graham, S.P., Graham, Simon P   +53 more
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Cytotoxic activity of invariant NKT cells in human allergic contact dermatitis [PDF]

, 2009
Cytotoxic activity of invariant NKT cells in human allergic contact dermatitis Background: The role of cytotoxicity of NKT-cells in the skin is not defined. There are two prototypic skin diseases in which epidermal Keratinocytes (KC) over-express CD1d, a
Balato, Anna
core   +1 more source

Synthesis of carbohydrate modified alpha-galactosylceramide analogs and the discovery of novel reactions involving strained heterocycles

, 2012
α-Galactosylceramide (KRN7000) was developed by Kirin Brewery Co., Ltd. in Japan. It exhibits potent anti-tumor activity in murine models and has also shown promising potential in the treatment of infectious and autoimmune diseases.
Keshipeddy, Santosh Kumar
core   +1 more source

Galactosylsphingamides: new α-GalCer analogues to probe the F’-pocket of CD1d

Scientific Reports, 2017
Invariant Natural Killer T-cells (iNKT-cells) are an attractive target for immune response modulation, as upon CD1d-mediated stimulation with KRN7000, a synthetic α-galactosylceramide, they produce a vast amount of cytokines.
Joren Guillaume, Jing Wang, Jonas Janssens, Soumya G. Remesh, Martijn D. P. Risseeuw, Tine Decruy, Mathy Froeyen, Dirk Elewaut, Dirk M. Zajonc, Serge Van Calenbergh   +9 more
doaj   +1 more source

Abrogation of Endogenous Glycolipid Antigen Presentation on Myelin-Laden Macrophages by D-Sphingosine Ameliorates the Pathogenesis of Experimental Autoimmune Encephalomyelitis

Frontiers in Immunology, 2019
Background: Although myelin is composed of mostly lipids, the pathological role of myelin lipids in demyelinating diseases remains elusive. The principal lipid of the myelin sheath is β-galactosylceramide (β-Galcer).
Yi Ban, Wenjuan Dong, Lixing Zhang, Tian Zhou, Tian Zhou, Ahmad S. Altiti, Khaleel Ali, David R. Mootoo, Victoria A. Blaho, Victoria A. Blaho, Timothy Hla, Yi Ren, Xiaojing Ma, Xiaojing Ma   +13 more
doaj   +1 more source

CD1d- and MR1-restricted T Cells in Sepsis

Frontiers in Immunology, 2015
Dysregulated immune responses to infection such as those encountered in sepsis can be catastrophic. Sepsis is typically triggered by an overwhelming systemic response to an infectious agent(s) and is associated with high morbidity and mortality even ...
Peter A. Szabo, Ram V. Anantha, Ram V. Anantha, Christopher R. Shaler, John K. McCormick, S.M. Mansour eHaeryfar, S.M. Mansour eHaeryfar   +6 more
doaj   +1 more source