Results 91 to 100 of about 10,260 (172)

Structure and binding kinetics of three different human CD1d-?-galactosylceramide-specific T cell receptors [PDF]

, 2006
Invariant human TCR V?24-J?18+/Vbeta11+ NKT cells (iNKT) are restricted by CD1d-?-glycosylceramides. We analyzed crystal structures and binding characteristics for an iNKT TCR plus two CD1d-?-GalCer-specific Vbeta11+ TCRs that use different TCR Valpha ...
Peter M. Villiger, E. Yvonne Jones, Gadola, Stephan D., Jones, E. Yvonne, Villiger, PM, Lissin, Nikolai M., Jakobsen, BK, Jon Marles-Wright, Jakobsen, Bent K., Koch, M, Marles-Wright, J, Cerundolo, Vincenzo, Stuart, David I., Lissin, NM, Marles-Wright, Jon, Cerundolo, V, Matulis, Gediminas, Gediminas Matulis, Karl Harlos, Stuart, David, Koch, Michael, Stuart, David I, Stephan D. Gadola, Jones, EY, Harlos, Karl, David I. Stuart, Michael Koch, Jakobsen, Bent K, Vincenzo Cerundolo, Lissin, Nikolai M, Jones, Edith, Gadola, SD, Villiger, Peter M, Shepherd, D, Harlos, K, Gadola, Stephan D, Jones, E Yvonne, Bent K. Jakobsen, Villiger, Peter M., Matulis, G, Dawn Shepherd, Shepherd, Dawn, Nikolai M. Lissin, Stuart, DI   +43 more
core   +1 more source

Synthesis of sulfated galactocerebrosides from an orthogonal b-D-galactosylceramide scaffold for the study of CD1-antigen interactions

, 2006
CD1a protein binds sulfatide (3-O-sulfo-b-D-galactosylceramide) to form an antigen complex that interacts with T cell receptors and activates T cells.
S. Ronchi, F. Compostella, L. Mori, F.C.V. Ronchetti, S. Mariotti, L. Panza, G. De Libero   +6 more
core   +1 more source

Developing an On‐Resin Synthesis of α‐Galactosylceramide‐Peptide Conjugate Vaccines

ChemistryEurope
The covalent attachment of peptide antigens to the NKT cell agonist, α‐galactosylceramide (αGalCer), generates self‐adjuvanting vaccines that prevent and/or eliminate disease in animal models of cancer and infectious disease.
Dr. Michael A. Meijlink, Dr. Susanna T. S. Chan, Kathryn J. Farrand, Sarah L. Draper, Dr. Oliva K. Burn, Jasmine M. Seifert‐Simpson, Ngarangi C. Mason, Dr. Lisa M. Connor, Prof. Ian F. Hermans, Prof. Gavin F. Painter, Dr. Benjamin J. Compton   +10 more
doaj   +1 more source

Differential distribution of galactosylceramide, H antigen, and carcinoembryonic antigen in rhesus macaque digestive mucosa.

, 1996
The most common route of transmission of HIV is via the mucosa. We compared human and macaque intestinal epithelia to determine whether the SIV macaque system can be used as a model to study HIV transmission by the rectal route.
C Butor, A Venet, A Couëdel-Courteille, J G Guillet   +3 more
core   +1 more source

Repeated administration of alpha-galactosylceramide ameliorates experimental lupus nephritis in mice

Scientific Reports, 2018
Lupus nephritis is a crucial complication of systemic lupus erythematosus. In this study, we investigated the roles of mouse natural killer T (NKT) cells in lupus nephritis.
Takahiro Uchida, Hiroyuki Nakashima, Akira Yamagata, Seigo Ito, Takuya Ishikiriyama, Masahiro Nakashima, Shuhji Seki, Hiroo Kumagai, Naoki Oshima   +8 more
doaj   +1 more source

Piglet Ileal Mucus Contains Protein and Glycolipid (Galactosylceramide) Receptors Specific for Escherichia coli K88 Fimbriae [PDF]

, 1993
The aim of this study was to characterize the Escherichia coli K88-specific receptors in mucus from the small intestines of 35-day-old piglets with the isogenic strains E. coli K-12(pMK005) (K88+) and E. coli K-12(pMK002) (K88-).
Krivan, Howard C., Cohen, Paul S., Conway, Patricia L., Blomberg, Lena   +3 more
core   +1 more source

A new alpha-C-galactosylceramide analog: promotion of Th1-biased responses in human CD1d-reactive V alpha 24-invariant natural killer T cells

, 2007
A new alpha-C-galactosylceramide analog: promotion of Th1-biased responses in human CD1d-reactive V alpha 24-invariant natural killer T ...
Robert Bittman (206623), Liping Song (2625808), Leonid S Metelitsa (15916493), Xuequan Lu (13100469)   +3 more
core   +1 more source

Localization of cholesterol, phosphocholine and galactosylceramide in rat cerebellar cortex with imaging TOF-SIMS equipped with a bismuth cluster ion source.

, 2005
Time-of-flight secondary-ion-mass-spectrometry (TOF-SIMS) was utilized to address the issue of co-localization of cholesterol, phosphocholine and galactosylceramide in rat cerebellar cortex.
B\uf6rner, Katrin, M\ue5nsson, Jan-Eric, Börner, Katrin,, Malmberg, Per, Nygren, H\ue5kan, Hagenhoff, Birgit, Nygren, Håkan,, Malmberg, Per,, Månsson, Jan-Eric,   +8 more
core   +1 more source

Modulation of NKT cells and Th1/Th2 imbalance after α-GalCer treatment in progressive load-trained rats

International Journal of Biological Sciences, 2009
Purpose: The purpose of this study was to determine whether α-galactosylceramide (α-GalCer), a synthetic glycolipid agonist of natural killer T (NKT) cells, can ameliorate exercise-induced immune imbalance.
Wang Ru, Chen Peijie
doaj  

Number of galectin-3-positive cell clusters, serum levels of galectin-3, degree of fibrosis, and inflammation score in liver tissue after alpha-galactosylceramide injection.

Number of galectin-3-positive cell clusters, serum levels of galectin-3, degree of fibrosis, and inflammation score in liver tissue after alpha-galactosylceramide injection.
Takahito Kuroda (14659881), Kosuke Mori (12017216), Takafumi Okubo (17935866), Tomohiro Kanayama (6256787), Kei Noguchi (6256784), Koki Ichihashi (14659884), Hiroyuki Tomita (3121689), Mikiko Matsuo (14659875), Akira Hara (649414), Yuko Imaizumi (14659878), Ayumu Kanbe (3105858), Ayumi Niwa (6256790)   +11 more
core   +1 more source