Results 61 to 70 of about 8,273 (177)

Development of a Self‐Adjuvanting Influenza Peptide–Glycolipid Conjugate Inducing CD8+ T‐Cell Immunity

ChemBioChem, Volume 27, Issue 5, 13 March 2026.
The glycolipid‐peptide antigen complexes for self‐adjuvanting conjugates were successfully synthesized, and, with the HLA‐transgenic mice, the antigen‐specific CD8+ T cell expansion was exhibited. The results provide useful insights for the design and synthesis of vaccine conjugates using glycolipid antigen as an adjuvant.
Shunya Kikuchi, Hideki Ogura, Takanori Matsumaru, Satoshi Ishido, Yukari Fujimoto   +4 more
wiley   +1 more source

Galactokinase 1 is the source of elevated galactose‐1‐phosphate and cerebrosides are modestly reduced in a mouse model of classic galactosemia

JIMD Reports
Classic galactosemia (CG) arises from loss‐of‐function mutations in the Galt gene, which codes for the enzyme galactose‐1‐phosphate uridylyltransferase (GALT), a central component in galactose metabolism.
Linley Mangini, Roger Lawrence, Manuel E. Lopez, Timothy C. Graham, Christopher R. Bauer, Hang Nguyen, Cheng Su, John Ramphal, Brett E. Crawford, Tom A. Hartl   +9 more
doaj   +1 more source

Electroacupuncture ameliorates vascular cognitive impairment through SIRT7‐mediated downregulation of H3K18 acetylation‐UBP1 in the hippocampus

Brain‐X, Volume 4, Issue 1, March 2026.
Electroacupuncture (EA) reduces H3K18ac enrichment at the Ubp1 promoter in the hippocampus in chronic cerebral hypoperfusion (CCH) rats by upregulating SIRT7‐mediated deacetylation, thereby suppressing the expression of UBP1. This EA‐dependent epigenetic regulation increases dendritic spine density and enhances long‐term potentiation, leading to ...
Wenju Wang, Sinuo Wang, Zhuoming Zheng, Yajun Cao, Mengquan Tan, Junzi Wang, Jiawei Jian, Yanyi Ding, Liming Chen, Zhongyi Hu, Yuxi Qiu, Changmei Lu, Yuwei Ye, Yangling Zheng, Yaling Dai, Siyuan Song, Minguang Yang, Weilin Liu   +17 more
wiley   +1 more source

Comparative Genomics of Pinna rudis and Pinna nobilis Reveals Conserved and Divergent Features of the Bivalve Defensome

Ecology and Evolution, Volume 16, Issue 3, March 2026.
We present the first high‐quality annotated genome of Pinna rudis and an updated genome assembly for Pinna nobilis, two Mediterranean fan mussel species differentially affected by mass mortality events. Comparative genomic analyses of gene sets associated with the “defensome” show that these genes are largely functionally conserved between the two ...
Stéphane Coupé, Mathieu Foulquié, Maite Vázquez Luis, Elvira Alvarez Perez, Jean‐Marc Prévot, Nardo Vicente, Robert Bunet   +6 more
wiley   +1 more source

3-O-acetyl-sphingosine-series myelin glycolipids

Journal of Lipid Research, 2002
Several glycosphingolipids, less polar than galactosylceramide (GalCer), have been purified from rat brain and designated as fast migrating cerebrosides (FMCs). They co-appear with GalCer during myelinogenesis, reach a peak concentration at postnatal day
Somsankar Dasgupta, Steven B. Levery, Edward L. Hogan   +2 more
doaj   +1 more source

Time-course analysis of liver and serum galectin-3 in acute liver injury after alpha-galactosylceramide injection.

PLoS ONE
Galectin-3 is a beta-galactoside-binding lectin that plays important roles in diverse physiological functions, such as cell proliferation, apoptosis, and mRNA splicing.
Mikiko Matsuo, Ayumu Kanbe, Kei Noguchi, Ayumi Niwa, Yuko Imaizumi, Takahito Kuroda, Koki Ichihashi, Takafumi Okubo, Kosuke Mori, Tomohiro Kanayama, Hiroyuki Tomita, Akira Hara   +11 more
doaj   +1 more source

Paucity of CD4+ natural killer T (NKT) lymphocytes in sooty mangabeys is associated with lack of NKT cell depletion after SIV infection.

PLoS ONE, 2010
Lack of chronic immune activation in the presence of persistent viremia is a key feature that distinguishes nonpathogenic simian immunodeficiency virus (SIV) infection in natural hosts from pathogenic SIV and HIV infection.
Namita Rout, James G Else, Simon Yue, Michelle Connole, Mark A Exley, Mark A Exley, Amitinder Kaur   +6 more
doaj   +1 more source

Galactosylsphingamides: new α-GalCer analogues to probe the F’-pocket of CD1d

Scientific Reports, 2017
Invariant Natural Killer T-cells (iNKT-cells) are an attractive target for immune response modulation, as upon CD1d-mediated stimulation with KRN7000, a synthetic α-galactosylceramide, they produce a vast amount of cytokines.
Joren Guillaume, Jing Wang, Jonas Janssens, Soumya G. Remesh, Martijn D. P. Risseeuw, Tine Decruy, Mathy Froeyen, Dirk Elewaut, Dirk M. Zajonc, Serge Van Calenbergh   +9 more
doaj   +1 more source

Abrogation of Endogenous Glycolipid Antigen Presentation on Myelin-Laden Macrophages by D-Sphingosine Ameliorates the Pathogenesis of Experimental Autoimmune Encephalomyelitis

Frontiers in Immunology, 2019
Background: Although myelin is composed of mostly lipids, the pathological role of myelin lipids in demyelinating diseases remains elusive. The principal lipid of the myelin sheath is β-galactosylceramide (β-Galcer).
Yi Ban, Wenjuan Dong, Lixing Zhang, Tian Zhou, Tian Zhou, Ahmad S. Altiti, Khaleel Ali, David R. Mootoo, Victoria A. Blaho, Victoria A. Blaho, Timothy Hla, Yi Ren, Xiaojing Ma, Xiaojing Ma   +13 more
doaj   +1 more source

CD1d- and MR1-restricted T Cells in Sepsis

Frontiers in Immunology, 2015
Dysregulated immune responses to infection such as those encountered in sepsis can be catastrophic. Sepsis is typically triggered by an overwhelming systemic response to an infectious agent(s) and is associated with high morbidity and mortality even ...
Peter A. Szabo, Ram V. Anantha, Ram V. Anantha, Christopher R. Shaler, John K. McCormick, S.M. Mansour eHaeryfar, S.M. Mansour eHaeryfar   +6 more
doaj   +1 more source