Results 61 to 70 of about 10,260 (172)

Beyond the Barrier: Epithelial Cells as Immune Sentinels in the Female Genital Tract

American Journal of Reproductive Immunology, Volume 95, Issue 5, May 2026.
ABSTRACT Epithelial cells (ECs) of the female genital tract (FGT) serve as an essential barrier and the first line of defense against sexually transmitted pathogens. Beyond providing a physical barrier, these cells actively contribute to immune responses through pathogen recognition, cytokine release, and modulation of adaptive immune responses ...
Lauren Jirik, Shreya Joshi, Aisha Nazli, Charu Kaushic   +3 more
wiley   +1 more source

Mixed Signals: T Cells as Architects of IgE Immunity

Immunological Reviews, Volume 339, Issue 1, May 2026.
ABSTRACT Food allergen‐specific IgE can cause significant pathology, yet the pathways that generate pathogenic, high‐affinity IgE remain incompletely understood. Increasing evidence suggests that IgE responses arise from the integration of multiple, and sometimes opposing, T cell–derived cues.
Abigail L. Tierney, Wallace P. Bezerra, Stephanie C. Eisenbarth, Adam Williams   +3 more
wiley   +1 more source

Expedient Synthesis of the α-C-Glycoside Analogue of the Immunostimulant Galactosylceramide (KRN7000)

, 2016
Key reactions in a concise synthesis of an α-C-galactosylceramide analogue of KRN7000 include a diastereoselective alkenylalane addition to an N-tert-butanesulfinyl imine and the use of an epoxidation/carbamate ring opening sequence to install the ...
Peter Wipf (134666), Joshua G. Pierce (1528897)   +1 more
core   +1 more source

Biological Roles Played by Sphingolipids in Dimorphic and Filamentous Fungi

mBio, 2018
Filamentous and dimorphic fungi cause invasive mycoses associated with high mortality rates. Among the fungal determinants involved in the establishment of infection, glycosphingolipids (GSLs) have gained increased interest in the last few decades.
Caroline Mota Fernandes, Gustavo H. Goldman, Maurizio Del Poeta   +2 more
doaj   +1 more source

Integrated Analysis of Gut Microbiota and Metabolome Profiling Reveals the Effects of Feeding Approaches on Infants' Gut Microenvironment

Food Science &Nutrition, Volume 14, Issue 4, April 2026.
This graphical abstract illustrates the gut microenvironment disparities between breastfed and formula‐fed infants at 6 months of age. Through multi‐omics analysis, breastfeeding was shown to establish a distinct ecological imprinting characterized by favorable microbial shifts and down‐regulated pro‐inflammatory arachidonic acid metabolism, thereby ...
Simin Zhu, Wenjuan Tu, Wenting Zhang, Li Qing, Chengan Wang   +4 more
wiley   +1 more source

Versatile synthesis of phenoxydiazirine-based fatty acid analogues and photoreactive galactosylceramide [PDF]

, 2002
application/pdfA versatile synthesis of diazirine-based photoreactive fatty acid analogues is reported. The key step is phenoxy alkylation of diazirine with halo alkyl acid esters.
畑中, 保丸, Hashimoto, Makoto, 橋本, 誠, Nabeta, Kensuke, Hatanaka, Yasumaru   +4 more
core  

Distribution of cholesterol and galactosylceramide in rat cerebellar white matter.

, 2006
White matter and the inner granular layer of rat cerebellum was analysed by imaging time-of-flight secondary-ion mass spectrometry (TOF-SIMS) equipped with a Bi+ ion cluster gun.
B\uf6rner, Katrin, M\ue5nsson, Jan-Eric, Tallarek, Elke, Börner, Katrin,, Malmberg, Per, Nygren, H\ue5kan, Hagenhoff, Birgit, Nygren, Håkan,, Malmberg, Per,, Månsson, Jan-Eric,   +9 more
core   +1 more source

Leishmania Extracellular Vesicles as a Preventive Vaccine Platform Against Leishmaniasis

Journal of Extracellular Vesicles, Volume 15, Issue 4, April 2026.
The potential of Leishmania‐derived extracellular vesicles (EVs) as a vaccine platform was investigated, emphasizing an affordable, GMP‐compliant production and purification method. Immunization with EV vaccines, either unadjuvanted or combined with α‐galactosylceramide (αGC), induced robust humoral and cellular immune responses, conferring protection ...
Ismail Cem Yilmaz, Ibrahim Tokmak, Muzaffer Yildirim, Tugce Canavar Yildirim, Elif Sena Ozkoc, Irem Evcili, Emre Mert Ipekoglu, İhsan Cihan Ayanoglu, Emre Dunuroglu, Dicle Caliskan, Harun Onler, Zeynep Arzum, Ceren Ulker, Olcay Mert, Ridvan Orkut, Ibrahim Oguzhan Tarman, Ulku Guler, Bekir Salih, Volkan Yazar, Gokcen Ozgun, Serap Birincioglu, Ahmet Ozbilgin, Bilgi Gungor, Ihsan Gursel, Mayda Gursel   +24 more
wiley   +1 more source

Galactokinase 1 is the source of elevated galactose‐1‐phosphate and cerebrosides are modestly reduced in a mouse model of classic galactosemia

JIMD Reports
Classic galactosemia (CG) arises from loss‐of‐function mutations in the Galt gene, which codes for the enzyme galactose‐1‐phosphate uridylyltransferase (GALT), a central component in galactose metabolism.
Linley Mangini, Roger Lawrence, Manuel E. Lopez, Timothy C. Graham, Christopher R. Bauer, Hang Nguyen, Cheng Su, John Ramphal, Brett E. Crawford, Tom A. Hartl   +9 more
doaj   +1 more source

Heparan Sulfate Proteoglycans in Immunity

Proteoglycan Research, Volume 4, Issue 2, April 2026.
ABSTRACT In immune cells, heparin was first identified in mast cells in the 1940s, followed by the discovery of heparan sulfate in lymphocytes and granulocytes during the 1970s and 1980s. Subsequent decades of research have revealed how heparan sulfate and heparin, conjugated to core proteins as heparan sulfate proteoglycans (HSPGs), act as versatile ...
Moe Iwai, Pyong Woo Park
wiley   +1 more source