Results 1 to 10 of about 2,030 (160)

Knockout of eight hydroxyproline-O-galactosyltransferases cause multiple vegetative and reproductive growth defects [PDF]

Cell Surface, 2023
Arabinogalactan-proteins (AGPs) are a family of hyperglycosylated hydroxyproline-rich cell wall proteins found throughout the plant kingdom. To date, eight Hydroxyproline-galactosyltransferases (Hyp-GALTs), named GALT2-GALT9, are known to catalyze the ...
Silvia Coimbra, Allan M Showalter, Michael Held   +2 more
exaly   +4 more sources

Allergic reactions associated with tsetse fly bites [PDF]

Annals of Medicine
Background Allergic reactions in response to arthropod bites are a growing concern worldwide. Alpha-Gal syndrome (AGS) is a red meat allergy associated with IgE antibodies against galactose-alpha-1,3-galactose (alpha-Gal), typically linked to tick bites ...
Rita Vaz-Rodrigues, Patrick P′Odyek Abila, Paul D. Kasaija, Moses Kibuuka, José de la Fuente   +4 more
doaj   +2 more sources

Hydroxyproline-O-Galactosyltransferases Synthesizing Type II Arabinogalactans Are Essential for Male Gametophytic Development in Arabidopsis

Frontiers in Plant Science, 2022
In flowering plants, male reproductive function is determined by successful development and performance of stamens, pollen grains, and pollen tubes. Despite the crucial role of highly glycosylated arabinogalactan-proteins (AGPs) in male gamete formation,
Silvia Coimbra, Allan M Showalter, Moreira Diana   +2 more
exaly   +3 more sources

Identification of a novel β-1,4-galactosyltransferase from Haemophilus parainfluenzae for efficient biosynthesis of lacto-N-neotetraose in Escherichia coli [PDF]

Synthetic and Systems Biotechnology
As an important member of human milk oligosaccharides (HMOs), lacto-N-neotetraose (LNnT) has been recognized as a promising HMO with many physiological activities for infants.
Dan Liu, Chenhui Ying, Yingqi Ping, Shanquan Liang, Qiaojuan Yan, Zhengqiang Jiang   +5 more
doaj   +2 more sources

Transcriptomic insights into arabinogalactan protein mechanism of action in galactosyltransferase octuple mutants [PDF]

Frontiers in Plant Science
Arabinogalactan-proteins (AGPs) are a family of hyperglycosylated hydroxyproline-rich glycoproteins essential for plant growth and development and generally contain 10% protein and 90% carbohydrate.
Damilola A. Ayorinde, Damilola A. Ayorinde, Gbolaga O. Olanrewaju, Gbolaga O. Olanrewaju, Allan M. Showalter, Allan M. Showalter   +5 more
doaj   +2 more sources

Functional characterization of hydroxyproline-O-galactosyltransferases for Arabidopsis arabinogalactan-protein synthesis

BMC Plant Biology, 2021
Background Arabinogalactan-proteins (AGPs) are structurally complex hydroxyproline-rich cell wall glycoproteins ubiquitous in the plant kingdom. AGPs biosynthesis involves a series of post-translational modifications including the addition of type II ...
Dasmeet Kaur, Michael A. Held, Mountain R. Smith, Allan M. Showalter   +3 more
doaj   +1 more source

A mechanism for bistability in glycosylation. [PDF]

PLoS Computational Biology, 2018
Glycosyltransferases are a class of enzymes that catalyse the posttranslational modification of proteins to produce a large number of glycoconjugate acceptors from a limited number of nucleotide-sugar donors.
Andrew G McDonald, Keith F Tipton, Gavin P Davey   +2 more
doaj   +1 more source

Disruption of Smad4 expression in T cells leads to IgA nephropathy-like manifestations. [PDF]

PLoS ONE, 2013
The link between glomerular IgA nephropathy (IgAN) and T helper 2 (Th2) response has been implicated, however, the mechanisms are poorly defined because of the lack of an appropriate model.
Hiroyuki Inoshita, Byung-Gyu Kim, Michifumi Yamashita, Sung Hee Choi, Yasuhiko Tomino, John J Letterio, Steven N Emancipator   +6 more
doaj   +1 more source

Two Hydroxyproline Galactosyltransferases, GALT5 and GALT2, Function in Arabinogalactan-Protein Glycosylation, Growth and Development in Arabidopsis. [PDF]

PLoS ONE, 2015
Hydroxyproline-O-galactosyltransferase (GALT) initiates O-glycosylation of arabinogalactan-proteins (AGPs). We previously characterized GALT2 (At4g21060), and now report on functional characterization of GALT5 (At1g74800).
Debarati Basu, Wuda Wang, Siyi Ma, Taylor DeBrosse, Emily Poirier, Kirk Emch, Eric Soukup, Lu Tian, Allan M Showalter   +8 more
doaj   +1 more source

Glycosylation of a Fasciclin-Like Arabinogalactan-Protein (SOS5) Mediates Root Growth and Seed Mucilage Adherence via a Cell Wall Receptor-Like Kinase (FEI1/FEI2) Pathway in Arabidopsis. [PDF]

PLoS ONE, 2016
Fundamental processes that underpin plant growth and development depend crucially on the action and assembly of the cell wall, a dynamic structure that changes in response to both developmental and environmental cues.
Debarati Basu, Lu Tian, Tayler Debrosse, Emily Poirier, Kirk Emch, Hayley Herock, Andrew Travers, Allan M Showalter   +7 more
doaj   +1 more source