Results 21 to 30 of about 2,030 (160)

Farnesyltransferase Enables Modular Assembly of Dual‐Functional Nanobody Conjugates for in Vivo Imaging of Inflammation

Angewandte Chemie, EarlyView.
A modular farnesyltransferase‐based chemoenzymatic platform enables fast, site‐specific labeling of nanobodies for PET imaging of inflammation. CD11b‐targeted PET agents selectively image myeloid‐driven inflammation, while CD45‐targeted PET agents provide sensitive whole‐body immune mapping.
Sneha Venkatachalapathy, Yoon Ho Lee, Ali Salehi Farid, Heydar Moravej, Sina Djafari Rouhani, Jennifer E. Rowley, Mohammad Rashidian, Mark D. Distefano   +7 more
wiley   +2 more sources

Determination of the binding affinities of Neisseria meningitidis serogroup W capsule polymerase with two nucleotide sugar substrates

BMC Research Notes, 2018
Objective Meningococcal meningitis is a public health burden. Immunization strategies have reduced global incidence of the disease. Glycoconjugate vaccines are the most effective type of vaccine to combat most causes of meningococcal meningitis.
Abeer Sharyan, Cendy Gonzalez, Ophelia Ukaegbu, Kayla Powell, Pumtiwitt C. McCarthy   +4 more
doaj   +1 more source

Chemoenzymatic Radiosynthesis of a Gluconate Transporter‐Targeted In Vivo Bacterial Sensor From Clinical [18F]FDG

Angewandte Chemie, EarlyView.
An efficient radiosynthesis of fluorine‐18 labeled gluconic acid ([18F]FGA) was developed using two readily available materials, 2‐deoxy‐2‐[18F]fluoro‐D‐glucose ([18F]FDG) and glucose oxidase. [18F]FGA is highly specific for bacterial gluconate metabolism mediated by gluconate permease (GntP) and gluconate kinase (GntK), with rapid clearance, low off ...
Sang Hee Lee, Jung Min Kim, Joseph Blecha, Robert R. Flavell, Michael A. Ohliger, Joanne Engel, Youngho Seo, David M. Wilson   +7 more
wiley   +2 more sources

Leishmania major survival in selective Phlebotomus papatasi sand fly vector requires a specific SCG-encoded lipophosphoglycan galactosylation pattern. [PDF]

PLoS Pathogens, 2010
Phlebotomine sand flies that transmit the protozoan parasite Leishmania differ greatly in their ability to support different parasite species or strains in the laboratory: while some show considerable selectivity, others are more permissive.
Deborah E Dobson, Shaden Kamhawi, Phillip Lawyer, Salvatore J Turco, Stephen M Beverley, David L Sacks   +5 more
doaj   +1 more source

Unraveling A4GALT Mechanism and Its Modulation With Adamantyl‐Galactosylceramide Analogues: Advancing Fabry Disease Therapeutic Strategies

Angewandte Chemie, EarlyView.
A 310‐helix‐mediated conformational switch promotes a front‐face SNi‐like catalysis by human A4GALT. Mechanism‐guided design identifies AdaGalCer as a selective modulator of globotriaosylceramide (Gb3) biosynthesis, opening a clear route toward new Fabry disease therapeutics.
Nicky de Koster, Òscar Vidal‐Gironès, Rowan de Graaf, Ken Kok, Lindsey T. Lelieveld, Jackelien Hoogervorst, Maria J. Ferraz, José Pablo Rivas‐Fernández, Rob F. Lammers, Herman S. Overkleeft, Johannes M. F. G. Aerts, Rolf G. Boot, Carme Rovira, Marta Artola   +13 more
wiley   +2 more sources

CRISPR-Cas9 multiplex genome editing of the hydroxyproline-O-galactosyltransferase gene family alters arabinogalactan-protein glycosylation and function in Arabidopsis

BMC Plant Biology, 2021
Background Arabinogalactan-proteins (AGPs) are a class of hydroxyproline-rich proteins (HRGPs) that are heavily glycosylated (> 90%) with type II arabinogalactans (AGs). AGPs are implicated in various plant growth and development processes including cell
Yuan Zhang, Michael A. Held, Dasmeet Kaur, Allan M. Showalter   +3 more
doaj   +1 more source

A Regulatory Network of Arabinogalactan Proteins, Glycosylation, and Nucleotide Sugars for Optimizing Mara des Bois Strawberries Postharvest Storage Quality

Plants
Arabinogalactan proteins (AGPs) and extensins influence cell wall assembly and regulate plant cell mechanical properties through interactions with extracellular matrix polymers.
María Isabel Escribano, Irene Romero, María Teresa Sanchez-Ballesta, Carmen Merodio   +3 more
doaj   +1 more source

Genome-Wide Analysis of Sorghum GT47 Family Reveals Functional Divergences of MUR3-Like Genes

Frontiers in Plant Science, 2018
Sorghum (Sorghum bicolor) is an important bioenergy crop. Its biomass mainly consists of the cellulosic and non-cellulosic polysaccharides, both which can be converted to biofuels.
Hua Xu, Anming Ding, Sihui Chen, Prince Marowa, Dian Wang, Min Chen, Ruibo Hu, Yingzhen Kong, Malcolm O’Neill, Guohua Chai, Gongke Zhou   +10 more
doaj   +1 more source

Human Serum Galactosyltransferase: Distinction, Separation and Product Identification of Two Galactosyltransferase Activities [PDF]

European Journal of Biochemistry, 1978
Two different galactosyltransferase activities have been found in normal sera from A and O donors. Galactosyltransferase A incorporated galactose from UDP‐Gal into sialic‐acid‐free ovine submaxillary mucin (asialo‐mucin), whereas galactosyltransferase B transferred galactose from UDP‐Gal to free N‐acetylglucosamine or N‐acetylglucosamine‐glycoproteins.
E G, Berger, I, Kozdrowski, M M, Weiser, D H, van den Eijnden, W E, Schiphorst   +4 more
openaire   +2 more sources

Glycosylation of arabinogalactan-proteins essential for development in Arabidopsis

Communicative & Integrative Biology, 2016
Arabinogalactan-proteins (AGPs) are ubiquitous cell wall components present throughout the plant kingdom. They are extensively post translationally modified by conversion of proline to hydroxyproline (Hyp) and by addition of arabinogalactan (AG ...
Allan M. Showalter, Debarati Basu
doaj   +1 more source